Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Proteins (SLC12A3)

SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. Additionally we are shipping Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Antibodies (85) and Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC12A3 6559 P55017
Rat SLC12A3 SLC12A3 54300 P55018
SLC12A3 20497 P59158
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Top Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Proteins at antibodies-online.com

Showing 6 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$448.00
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$632.50
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SLC12A3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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Mouse (Murine) ,
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More Proteins for Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Interaction Partners

Human Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) interaction partners

  1. Report novel SLC12A3 mutations in Chinese patients with Gitelman syndrome.

  2. we identified a novel SLC12A3 mutation in a Chinese GS pedigree, leading to the substitution of leucine by proline at codon 700 of the NCCT transporter. The proband and his elder sister had a homozygous mutation, while his mother and daughter carried one mutated allele. Because only the proband suffered from bilateral lower limb weakness, we inferred that the same genotype manifests as diverse phenotypes.

  3. MDCKI cells can be used to assess the activity, cellular localization, and abundance of wild-type or mutant NCC.

  4. In wild-type, total (tNCC (show TNNC1 Proteins)) and phosphorylated (pNCC) NCC protein expressions were 1.8- and 4.6-fold higher in females compared with males, consistent with the larger response to HCTZ. In AT1a receptor knockout mice, tNCC (show TNNC1 Proteins) and pNCC increased significantly in males to levels not different from those in females.

  5. NCC1 (show CCL13 Proteins)/2, NCC1 (show CCL13 Proteins)-3, and pNCC1-3-T55/T60 are upregulated by hydrochlorothiazide, and the increase in NCC abundance in urinary extracellular vesicles of essential hypertensive patients correlates with the blood pressure response to hydrochlorothiazide.

  6. Data show that WNK lysine deficient protein kinase 3 protein (WNK3) interacts with NCC and increases the Na-Cl cotransporter (NCC) expression on the cell membrane and in cytoplasm together.

  7. variants of the SLC12A3 gene confer susceptibility to the abnormal serum LDL-c level in the Mongolian population.

  8. A significant association of the SLC12A3 rs11643718 and ELMO1 (show ELMO1 Proteins) rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.

  9. This paper identified a novel SLC12A3 allele in Gitelman syndrome that activates a cryptic exon flanked by interspersed repeats deep in intron 12.

  10. SLC12A3 gene homozygous mutation is associated with Gitelman syndrome.

Mouse (Murine) Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) interaction partners

  1. Calcineurin is activated by an acute potassium load, which rapidly dephosphorylates NCC, leading to increased urinary potassium excretion.

  2. long-term aldosterone administration stimulates mouse NCC and pT58-NCC abundances in late distal convoluted kidney tubules.

  3. Potassium depletion stimulates NCC via phosphorylation and inactivation of the KLHL3 (show KLHL3 Proteins) and promoting increased blood pressure.

  4. the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4 (show WNK4 Proteins)-SPAK (show STK39 Proteins) signal pathway using WNK4 (show WNK4 Proteins)-/- and SPAK (show STK39 Proteins)-/- mice.

  5. The Role of Epithelial Sodium Channel ENaC (show SCNN1A Proteins) and the Apical Cl-/HCO3- Exchanger Pendrin (show SLC26A4 Proteins) in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.

  6. This study identifies NCC as an IL18 (show IL18 Proteins)-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis.

  7. Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db (show LEPR Proteins) mice from 6, 12, and 26 weeks at the age.

  8. SPAK (show STK39 Proteins)-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure.

  9. NCC inhibition stimulates duodenal Ca(2 (show CA2 Proteins)+) absorption as well as osteoblast differentiation and bone Ca(2 (show CA2 Proteins)+) storage, possibly through a FAK (show PTK2 Proteins)/ERK (show EPHB2 Proteins) dependent mechanism

  10. P2Y2 (show P2RY2 Proteins)-mediated increase of cytoplasmic Ca(2 (show CA2 Proteins)+) concentration down-regulates the expression of NCC.

Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Protein Profile

Protein Summary

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC12A3

  • solute carrier family 12 (sodium/chloride transporters), member 3 (SLC12A3)
  • thiazide-sensitive sodium chloride cotransporter (NCCT)
  • solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 (slc12a3.2)
  • solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3)
  • solute carrier family 12 (sodium/chloride transporter), member 3 (Slc12a3)
  • solute carrier family 12, member 3 (Slc12a3)
  • AI035291 protein
  • DKFZp469N2315 protein
  • NCC protein
  • NCCT protein
  • slc12a3 protein
  • TSC protein

Protein level used designations for SLC12A3

solute carrier family 12 (sodium/chloride transporters), member 3 , thiazide-sensitive sodium chloride cotransporter , solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 , solute carrier family 12 member 3-like , Na-Cl cotransporter , Na-Cl symporter , NaCl electroneutral thiazide-sensitive cotransporter , solute carrier family 12 member 3 , thiazide-sensitive Na-Cl cotransporter , thiazide-sensitive sodium-chloride cotransporter , solute carrier family 12, member 3 , sodium chloride cotransporter

GENE ID SPECIES
415692 Gallus gallus
454108 Pan troglodytes
703090 Macaca mulatta
100009348 Oryctolagus cuniculus
100038063 Xenopus (Silurana) tropicalis
100051953 Equus caballus
100172399 Pongo abelii
100409101 Callithrix jacchus
100468795 Ailuropoda melanoleuca
100015656 Monodelphis domestica
6559 Homo sapiens
54300 Rattus norvegicus
478118 Canis lupus familiaris
404171 Bos taurus
20497 Mus musculus
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