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Solute Carrier Family 13 Member 2 Proteins (SLC13A2)

facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate [RGD, Feb 2006].. Additionally we are shipping Solute Carrier Family 13 Member 2 Antibodies (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC13A2 100508689  
SLC13A2 20500 Q9ES88
Rat SLC13A2 SLC13A2 65202  
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Top Solute Carrier Family 13 Member 2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$310.00
Details

SLC13A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Solute Carrier Family 13 Member 2 (SLC13A2) Interaction Partners

Human Solute Carrier Family 13 Member 2 (SLC13A2) interaction partners

  1. cyclophilin (show PPIA Proteins) isoform B is likely responsible for down-regulation of carrier expression by CsA (show ERCC8 Proteins) and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase (show FKBP1B Proteins) activity.

  2. study concludes most of the naturally occurring nonsynonymous SNPs affect protein processing of NaDC1; several also affect functional properties; mutations are predicted to decrease transport activity

  3. This paper describes the cloning and functional characterization of the human Na(+)-coupled citrate transporter (NaCT).

  4. Data show that the sodium-dependent dicarboxylate co-transporter protein (show HNRNPU Proteins) 1 is located in renal proximal tubule lumenal membranes, and that the C-terminal sequence is required for delivery and targeting and may contain the signal sequence.

  5. The Ser (show SIGLEC1 Proteins) or Thr (show TRH Proteins) at position 509 is the most important determinant of functional differences in apparent affinity for substrate and cations. The cation and substrate binding sites are located in close proximity to one another.

Rabbit Solute Carrier Family 13 Member 2 (SLC13A2) interaction partners

  1. Data show that NaDC1 F336C had increased transport activity due to an increased Vmax for succinate.

Mouse (Murine) Solute Carrier Family 13 Member 2 (SLC13A2) interaction partners

  1. Slc26a6 (show SLC26A6 Proteins)-null mice exhibit increased renal and intestinal sodium-dependent succinate uptake, as well as urinary hyperoxaluria and hypocitraturia, but no change in urinary pH, indicating enhanced transport activity of NaDC-1.

  2. The acid-activated pathway mediating stimulation of kidney NaDC-1 activity requires a functional ET(B (show EDNRB Proteins)) receptor in vivo and in vitro.

  3. Substrate-dependent inward currents, measured using two-electrode voltage clamp, were similar for glutarate & succinate in Xenopus oocytes expressing mouse NaDC1. Currents evoked by glutarate in rabbit NaDC1 were about 5% of succinate-dependent currents.

  4. Sodium dicarboxylate cotransporter is involved in regulating levels of various Krebs cycle intermediates in the kidney, although impaired uptake of these intermediates does not significantly affect renal function under normal or ischemic stress.

Solute Carrier Family 13 Member 2 (SLC13A2) Protein Profile

Protein Summary

facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate

Gene names and symbols associated with SLC13A2

  • solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 (SLC13A2)
  • deleted in malignant brain tumors 1 (DMBT1)
  • mucin (LOC100508689)
  • solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 (Slc13a2)
  • INDY protein
  • mNaDC-1 protein
  • mucin protein
  • NaCT protein
  • NaDC-1 protein
  • Nadc1 protein
  • SDCT1 protein

Protein level used designations for SLC13A2

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 , gall-bladder mucin , Na(+)-coupled citrate transporter , Na(+)/dicarboxylate cotransporter 1 , renal sodium/dicarboxylate cotransporter , solute carrier family 13 member 2 , solute carrier family 13, member 2 , sodium/dicarboxylate cotransporter , naDC-1 , sodium/dicarboxylate co-transporter , intestinal sodium/dicarboxylate cotransporter , sodium-dependent dicarboxylate transporter

GENE ID SPECIES
454528 Pan troglodytes
491167 Canis lupus familiaris
404104 Bos taurus
100508689 Homo sapiens
9058 Homo sapiens
505069 Bos taurus
100009593 Oryctolagus cuniculus
20500 Mus musculus
65202 Rattus norvegicus
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