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Solute Carrier Family 13 Member 3 Proteins (SLC13A3)

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. Additionally we are shipping Solute Carrier Family 13 Member 3 Antibodies (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC13A3 64849 Q8WWT9
SLC13A3 114644 Q91Y63
Rat SLC13A3 SLC13A3 64846  
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Top Solute Carrier Family 13 Member 3 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

SLC13A3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Solute Carrier Family 13 Member 3 (SLC13A3) Interaction Partners

Human Solute Carrier Family 13 Member 3 (SLC13A3) interaction partners

  1. OAT1 (show KCNK3 Proteins) and NaDC3 in the basolateral membrane and OAT4 (show SLC22A9 Proteins) in the luminal membrane of proximal tubule cells are responsible for the avid renal secretion of N-carbamoylglutamate.

  2. In a study addressing genetic, social, and environmental contributors of chronic kidney disease with tubulointerstitial damages in Sri (show SRI Proteins) Lanka, SNP rs6066043 of SLC13A3 was found attributable risk of 50%.

  3. study concludes NaDC3 present at the basolateral membrane of proximal tubule cells mediates sodium-dependent glutathione (GSH) uptake; the kinetic data show that NaDC3 is a low-affinity GSH transporter

  4. The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1 (show KCNK3 Proteins), and OAT3 (show SLC22A8 Proteins)

  5. The results indicate that SLC13A3 is a direct downstream target of PITX2 (show PITX2 Proteins) transcriptional regulation and that levels of PITX2 (show PITX2 Proteins) and SLC13A3 modulate responses to oxidative stress in ocular cells.

  6. NaDC3 promotes cellular senescence probably by inhibiting NAD(+)-dependent SIRT1 (show SIRT1 Proteins).

  7. The narrow substrate specificity prevents interaction of drugs with dicarboxylate-like structure with hNaDC-3 and ensures sufficient support of the proximal tubule cells with alpha-ketoglutarate for anion secretion via organic anion transporter 1 (show SLC22A6 Proteins) or 3.

  8. We provide direct evidence of the localization of NaDC3 at the basolateral membrane of human renal proximal tubule cells and identify a di-hydrophobic amino acid motif VW as basolateral localization signal in the N-terminal cytoplasmic domain of NaDC3.

Mouse (Murine) Solute Carrier Family 13 Member 3 (SLC13A3) interaction partners

  1. demonstrate the membrane translocation of 3OH-GA mediated by NaDC3 and the cis (show CISH Proteins)-inhibitory effect on OCT2 (show SLC22A2 Proteins)-mediated transport of cations

Solute Carrier Family 13 Member 3 (SLC13A3) Protein Profile

Protein Summary

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.

Gene names and symbols associated with SLC13A3

  • solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (slc13a3)
  • solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (SLC13A3)
  • solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (Slc13a3)
  • MGC108337 protein
  • NaDC-3 protein
  • Nadc3 protein
  • SDCT2 protein
  • SLC13A3 protein
  • zgc:77173 protein

Protein level used designations for SLC13A3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 , solute carrier family 13 member 3 , Na(+)/dicarboxylate cotransporter 3 , hNaDC3 , naDC-3 , sodium-dependent high affinity dicarboxylate transporter 3 , sodium-dependent high-affinity dicarboxylate transporter 2 , mNaDC3 , rNaDC3 , sodium-dependent high-affinity dicarboxylate transporter 3

GENE ID SPECIES
548493 Xenopus (Silurana) tropicalis
100029726 Monodelphis domestica
100071226 Equus caballus
458302 Pan troglodytes
405838 Danio rerio
444773 Xenopus laevis
770495 Gallus gallus
64849 Homo sapiens
485910 Canis lupus familiaris
526291 Bos taurus
114644 Mus musculus
64846 Rattus norvegicus
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