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The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. Additionally we are shipping and many more products for this protein.
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Human Polyclonal SLC15A2 Primary Antibody for ELISA - ABIN4237906
Hu, Shen, Keep, Smith: Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity. in Journal of neurochemistry 2007
Responses of oligopeptide transporter 2 (PepT2) to lactogenic hormones and oligopeptide inferred that it may play an important role in bovine mammary gland.
We characterized the functional properties of a novel zebrafish peptide transporter orthologous to mammalian and avian PEPT2, described its gene (pept2) structure, and determined mRNA tissue distribution
beta-Klotho (show KLB Antibodies) participates in the regulation of the peptide transporters PEPT1 (show SLC15A1 Antibodies) and PEPT2.
Data suggest that USP18 (show USP18 Antibodies) (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 (show SLC15A1 Antibodies) and PEPT2.
SPAK (show STK39 Antibodies) is a powerful regulator of peptide transporters PEPT1 (show SLC15A1 Antibodies) and PEPT2
We found marked changes in protein expression and functional activity of PhT1 (show SLC15A4 Antibodies) and PepT2, the former predominating in adult and the latter in neonate
JAK3 (show JAK3 Antibodies) is a powerful regulator of the peptide transporters PEPT1 (show SLC15A1 Antibodies) and PEPT2.
The study presents a pharmacokinetic model to quantitate the distribution kinetics of glycylsarcosine, a substrate of PepT2, in blood, cerebrospinal fluid and kidney in wild-type and PepT2 knockout mice.
PEPT2 is responsible for dipeptide uptake in choroid plexus tissue
PEPT2 is the main system responsible for tubular reabsorption of peptide-bound amino acids, although this does not lead to major changes in renal excretion of protein or free amino acids.
Studies in transgenic mice demonstrated that PEPT2 was responsible for over 90% of carnosine uptake in choroid plexus. These findings elucidate the unique role of PEPT2 in regulating neuropeptide homeostasis at the blood-cerebrospinal fluid interface
The role of PEPT2 in the uptake of glycylsarcosine and 5-aminolevulinic acid in choroid plexus whole tissue from wild type and knockout mice.
PEPT2-mediated dipeptide transport in enteric glia could contribute to the clearance of neuropeptides in the ENS.
Pept2 mRNA was the highest in kidney, followed by brain and lung
When fed diets with different protein contents, Pept2-/- mice adapted food intake to dietary protein content with higher consumption rates on low protein and reduced food intake rates on the high protein diet.
PEPT2 is expressed in keratinocytes and involved in skin oligopeptide uptake.
PEPT2 is functionally expressed in H441 cells, making the cell line a good in vitro model to study PEPT2 function and its regulation in human distal lung.
In vitro study displayed different response to sorafenib depending on the genotype of SLC15A2.
OSR1 (show OXSR1 Antibodies) has the capacity to downregulate the peptide transporters PEPT1 (show SLC15A1 Antibodies) and PEPT2 by decreasing the carrier protein abundance in the cell membrane
LNCaP expresses high levels of PEPT2 and PHT1 (show SLC15A4 Antibodies).
PEPT1,PEPT2, PHT1, and PHT2 are expressed in human nasal epithelium.
PepT2-mRNA is expressed in U373-MG and glial cells but showed no regulation of PepT2-mRNA expression in both cell types.
Data identify Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated transporters.
anserine is recognized by the proton-coupled peptide transporters PEPT1 (show SLC15A1 Antibodies) and PEPT2 with medium affinity. Anserine is able to displace other substrates from the transport process.
The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995
peptide transporter 2
, solute carrier family 15 (H+/peptide transporter), member 2
, solute carrier family 15 member 2
, peptide transporter PEPT2
, proton-dependent dipeptide transporter PEPT2
, solute carrier family 15 member 2-like
, H+ coupled di/tri-peptide cotransporter 2
, kidney H(+)/peptide cotransporter
, oligopeptide transporter, kidney isoform
, Slc15a2 variant A
, Slc15a2 variant A2
, proton-dependent high affinity oligopeptide transporter PepT2
, solute carrier family 15, member 2