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SLC15A1 encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. Additionally we are shipping SLC15A1 Proteins (6) and SLC15A1 Kits (2) and many more products for this protein.
Showing 10 out of 65 products:
Chicken Polyclonal SLC15A1 Primary Antibody for FACS, IF (cc) - ABIN671961
Xu, Wu, Liu, Xie, Huang, Liu: Establishment and characterization of an omasal epithelial cell model derived from dairy calves for the study of small peptide absorption. in PLoS ONE 2014
Chicken Polyclonal SLC15A1 Primary Antibody for IHC, ELISA - ABIN1582111
Takeda, Park, Kunitake, Yoshiura, Matsui: Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1. in Food chemistry 2013
PepT1 mRNA expression in the distal jejunum increased gradually with age in suckling Tibetan piglet
PEPT1 overexpression is associated with pancreatic cancer.
Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil.
Phe-Psi-Ala is a high-affinity, metabolically stable, non-radioactive probe for PEPT1.
miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation.
OSR1 (show OXSR1 Antibodies) has the capacity to downregulate the peptide transporters PEPT1 and PEPT2 (show SLC15A2 Antibodies) by decreasing the carrier protein abundance in the cell membrane
The PEPT1 rs2297322 single-nucleotide polymorphism was not associated with inflammatory bowel disease susceptibility in our German cohort.
Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, could play a crucial role in cell-to-cell communication during colitis
The present review summarizes the recent knowledge on the factors modulating PEPT1 expression/function in Caenorhabditis elegans, Danio rerio, Mus (show TRPV6 Antibodies) musculus and Homo sapiens, with focus on dietary ingredients, transcription factors and modulators.[review]
promoter constructs were generated and cotransfected with an Nrf2 (show GABPA Antibodies) expression plasmid
JAK3 (show JAK3 Antibodies) is a powerful regulator of the peptide transporters PEPT1 and PEPT2 (show SLC15A2 Antibodies).
Glycosylation of PEPT1 confers resistance against proteolytic cleavage by proteinase K, whereas a remarkable intrinsic stability against trypsin, even in the absence of N-linked glycans, was detected.
We tested the hypothesis that PEPT2 (show SLC15A2 Antibodies) genotypes affect the severity and prognosis of porphyria-associated kidney disease
findings suggested a major role of PEPT1 in the intestinal permeability and oral absorption of 5-aminolevulinic acid
Crystal structures of the extracellular domain from PepT1 and PepT2 (show SLC15A2 Antibodies) provide novel insights into mammalian peptide transport.
PEPT1 expression is reduced during intestinal inflammation and PEPT1 is not required for muramyl dipeptide-induced immune response.
Data indicate that peroxisome proliferator-activated receptor-alpha (PPARalpha (show PPARA Antibodies)) activated the intestinal expression of Slc15a1 mRNA during the light period, and protein levels of PepT1 peaked before the start of the dark phase.
PepT1 deletion reduced the area under the plasma concentration-time profile (AUC0-120) of cefadroxil by 10-fold, the maximum plasma concentration (Cmax) by 17.5-fold, and increased the time to reach a maximum plasma concentration (Tmax) by 3-fold.
The PepT1 profile and expression in gastrointestinal epithelial cells of yak varied from those of cattle, implying that yak have evolved a peptide transport mechanism to adapt the environment of the Qinghai-Tibetan plateau.
beta-Klotho (show KLB Antibodies) participates in the regulation of the peptide transporters PEPT1 and PEPT2 (show SLC15A2 Antibodies).
Data suggest that USP18 (show USP18 Antibodies) (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 and PEPT2 (show SLC15A2 Antibodies).
SPAK (show STK39 Antibodies) is a powerful regulator of peptide transporters PEPT1 and PEPT2 (show SLC15A2 Antibodies)
Appropriate amino acid substitutions of Arg(282) and Asp (show ASIP Antibodies)(341) change the properties of PepT1 in a way that confirms that these parts of the protein act as an electrostatic gate in the transport process.
Report PepT1 kinetics in vitro and using computer simulated kinetic models.
The role of conserved tyrosines in the transmembrane domains (TMDs) of rabbit PepT1 as predicted by hydropathy plots, was investigated.
Mutation of rabbit PepT1 arginine282 R282E- and R282D-PepT1 showed an increased charge:peptide stoichiometry over the wild-type 1:1 ratio for the neutral dipeptide Gly-l-Gln, measured using two-electrode voltage clamp.
Report substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes.
These results suggest that PepT1 may be a contributing mechanism to compensatory growth that could influence cholecystokinin (show CCK Antibodies) secretion and gastrin-releasing peptide (show GRP Antibodies) and ghrelin (show GHRL Antibodies) activity.
PEPT1 maximal transport rates unexpectedly increase at alkaline extracellular pH; pept1 is highly expressed in the proximal intestine since day 4 post-fertilisation, preceding functional maturation of the gut (show GUSB Antibodies)
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.
peptide transporter 1
, solute carrier family 15 member 1
, solute carrier family 15 (oligopeptide transporter), member 1
, proton-dependent dipeptide transporter PEPT1
, solute carrier family 15 member 1-like
, Caco-2 oligopeptide transporter
, intestinal H+/peptide cotransporter
, macrophage oligopeptide transporter PEPT1
, oligopeptide transporter, small intestine isoform
, intestinal H(+)/peptide cotransporter
, intestinal peptide transporter PEPT1
, proton-coupled dipeptide cotransporter
, peptide transporter PepT1
, proton-dependent gastrointestinal peptide transporter 1
, pineal gland-specific PEPT1
, proton-coupled peptide cotransporter PepT1