Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) Proteins (SLC16A1)

The protein encoded by SLC16A1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Additionally we are shipping SLC16A1 Antibodies (75) and SLC16A1 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC16A1 6566 P53985
Rat SLC16A1 SLC16A1 25027 P53987
SLC16A1 20501 P53986
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Top SLC16A1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
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HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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SLC16A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) Interaction Partners

Zebrafish Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) interaction partners

  1. Data indicate that monocarboxylate transporters (MCTs1 (show MCTS1 Proteins)-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.

Horse (Equine) Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) interaction partners

  1. The expression of monocarboxylic acid transporter 1 (MCT1), MCT2, and CD147 in 3 horse breeds with different atheletic demands is reported.[MCT1; MCT2]

  2. Results indicated that a single IET resulted in transient increases in MCT1 (show MCTS1 Proteins) and MCT4 (show SLC16A3 Proteins) mRNA expression and protein content in untrained and trained horses.

  3. The coding sequence of MCT1 (show MCTS1 Proteins), MCT4 (show SLC16A3 Proteins), and CD147 (show BSG Proteins) in healthy horses, and the incidence of polymorphisms of these proteins in horses with excercise-induced myopathy are reported.

  4. MCT1 (show MCTS1 Proteins) protein content in GMM samples obtained when the horses were 24 months old was significantly higher than at 2 months of age. However, MCT4 (show SLC16A3 Proteins) protein content remained unchanged throughout the study period.

Human Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) interaction partners

  1. Data show that metastasis-associated in colon cancer-1 (MACC1 (show MACC1 Proteins)) and monocarboxylate transporter 1 (MCT1) are highly expressed in gastric cancer indicating poor prognosis.

  2. AA genotype of the MCT1 (show CMA1 Proteins) T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s Wingate Anaerobic test and during intermittent sprint tests in Japanese wrestlers

  3. MCT1 (show CMA1 Proteins) and MCT4 (show SLC16A4 Proteins) expression levels were associated with worse prognosis and shorter overall survival.

  4. MCT1 (show CMA1 Proteins) may be acting as an uptake transporter and MCT4 (show SLC16A4 Proteins) as an efflux system across the basolateral membrane for ferulic acid, and that this process is stimulated by butyric acid.

  5. After indirect co-culture, OP was increased in the BxPc-3 and Panc-1 cells; correspondingly, succinate dehydrogenase (show SDHA Proteins), FH and MCT (show MCAT Proteins) expression were increased. After the MCT1 (show CMA1 Proteins)-specific inhibitor removed 'tumor-stromal' metabolic coupling, the migration and invasion abilities of the pancreatic cancer cells were decreased.

  6. Data suggest that inhibition of mnocarboxylate transporters MCT1 (show CMA1 Proteins) and MCT4 (show SLC16A4 Proteins) may have clinical relevance in pancreatic ductal adenocarcinoma (PDAC).

  7. Results found that MCT (show MCAT Proteins) contributes to endothelial cell growth and tube formation via up-regulation of angiopoietin-1 (show ANGPT1 Proteins) expression suggesting that MCT (show MCAT Proteins) plays an important role in pancreatic cancer angiogenesis and tumor growth via activating the angiopoietin-1 (show ANGPT1 Proteins) pathway.

  8. The targeting of MCT1 (show CMA1 Proteins) and PFKFB3 (show PFKFB3 Proteins) regulated cell proliferation.

  9. MCT1 (show CMA1 Proteins) expression associates with the SCC (show CYP11A1 Proteins) type and metastatic behavior of AC, whereas MCT4 (show SLC16A4 Proteins) expression concomitantly increases from in situ SCC (show CYP11A1 Proteins) to invasive SCC (show CYP11A1 Proteins) and is significantly associated with the AC type. Consistently, FOXM1 (show FOXM1 Proteins) expression is statistically associated with MCT1 (show CMA1 Proteins) positivity in SCC (show CYP11A1 Proteins), whereas the expression of FOXO3a (show FOXO3 Proteins), a FOXM1 (show FOXM1 Proteins) functional antagonist, is linked to MCT1 (show CMA1 Proteins) negativity

  10. This study investigated MCT1 (show CMA1 Proteins) protein abundance in various human intestinal tissues.

Mouse (Murine) Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) interaction partners

  1. Exercise-induced changes in tumour LDH-B (show LDHB Proteins) and MCT1 (show MCTS1 Proteins) expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice

  2. Chronic lactate administration after exercise increases MCT1 (show MCTS1 Proteins) protein expression, which can be involved in the regulation of the observed increase in muscle glycogen (show GYS1 Proteins) storage after exercise training.

  3. This study showed that mouse MCT1 (show MCTS1 Proteins), MCT2, and MCT4 (show SLC16A3 Proteins) are expressed in the PNS. While DRG neurons express MCT1 (show MCTS1 Proteins), myelinating Schwann cells.

  4. These data for the first time demonstrate that MCT1 (show MCTS1 Proteins) is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush

  5. in Parkinson's disease, the levels of MCT1 (show MCTS1 Proteins), MCT2 and GLUT1 (show SLC2A1 Proteins) is not changed following dopaminergic neurodegeneration

  6. results suggest that a reduction in mitochondria is a result, rather than the cause, of the metabolic deficiency observed in Basigin (show BSG Proteins)-null mice, and likely occurs because of reduced metabolic activity in the absence of MCT1 (show MCTS1 Proteins) expression.

  7. miR (show MLXIP Proteins)-29a, miR (show MLXIP Proteins)-29b selectively target MCT1 (show MCTS1 Proteins) 3'UTR ; the miR (show MLXIP Proteins)-29 isoforms are highly expressed in islets and contribute to silencing Mct1 (show MCTS1 Proteins) in beta cells; miR (show MLXIP Proteins)-29 isoforms contribute to beta-cell-specific silencing of the MCT1 (show MCTS1 Proteins) transporter and may affect insulin (show INS Proteins) release

  8. monocarboxylate transporter 1 (MCT1), is highly enriched within oligodendroglia and disruption of this transporter produces axon damage and neuron loss in animal and cell culture models; in addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 (show MCTS1 Proteins) in pathogenesis

  9. It was shown that forced overexpression of MSlc16a1 in beta-cells replicates the key features of exercise-induced hyperinsulinism and highlights the importance of this transporter's absence from these cells for the normal control of insulin (show INS Proteins) secretion.

  10. MCT1 (show MCTS1 Proteins) and MCT4 (show SLC16A3 Proteins) protein expression increased by 92 and 61%, respectively, after 12 days of functional overload (p < 0.05).

Cow (Bovine) Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) interaction partners

  1. This study confirmed age-dependent changes of MCT1 (show MCTS1 Proteins) expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.

  2. These findings show that MCT 1 (show MCTS1 Proteins) increases with the development of rumen function and also in adult animals MCT 1 (show MCTS1 Proteins) may change with the feeding.

  3. The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.

  4. The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.

SLC16A1 Protein Profile

Protein Summary

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with SLC16A1

  • solute carrier family 16 (monocarboxylic acid transporters), member 1 (slc16a1)
  • solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (SLC16A1)
  • solute carrier family 16 (monocarboxylate transporter), member 1 (SLC16A1)
  • solute carrier family 16 (monocarboxylate transporter), member 1 (Slc16a1)
  • solute carrier family 16 (monocarboxylic acid transporters), member 1 (Slc16a1)
  • AL022710 protein
  • cb517 protein
  • DKFZp469B1212 protein
  • HHF7 protein
  • MCT protein
  • Mct1 protein
  • MCT1a protein
  • MGC52993 protein
  • RATMCT1 protein
  • RNMCT1 protein
  • SLC16A1 protein
  • zgc:55682 protein

Protein level used designations for SLC16A1

MCT1 , monocarboxylate transporter 1 , monocarboxylate transporter 1a , solute carrier family 16 (monocarboxylic acid transporters), member 1 , solute carrier family 16, member 1 (monocarboxylic acid transporter 1) , solute carrier family 16 member 1 , monocarboxylate transporter 1-like , MCT 1 , solute carrier 16 (monocarboxylic acid transporter), member 1

GENE ID SPECIES
368274 Danio rerio
380088 Xenopus laevis
443456 Ovis aries
457096 Pan troglodytes
100009694 Equus caballus
100174496 Pongo abelii
100398254 Callithrix jacchus
100480919 Ailuropoda melanoleuca
100582053 Nomascus leucogenys
6566 Homo sapiens
25027 Rattus norvegicus
20501 Mus musculus
505775 Bos taurus
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