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SLC16A7 is a member of the monocarboxylate transporter family. Additionally we are shipping SLC16A7 Kits (4) and and many more products for this protein.
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Human Polyclonal SLC16A7 Primary Antibody for WB - ABIN374099
Lin, Vera, Chaganti, Golde: Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. in The Journal of biological chemistry 1998
SLC16A7 (MCT2) epigenetic regulation results in protein over-expression, affecting signalling and cellular phenotypes in prostate cancer
Data suggest that monocarboxylate transporter 2 (MCT2) at peroxisomes is related to an increase in beta-oxidation levels which may be crucial for malignant transformation.
This study identified that CGPs was found to significantly correlate with the differential expression and methylation of genes encoding solute carrier (show SERTAD2 Antibodies) family 16, member 7.
Our findings suggest that SNPs in MCT1 (show CMA1 Antibodies) and MCT2 genes may affect clinical outcomes and can be used to predict the response to adjuvant chemotherapy in NSCLC patients who received surgical treatment once validated in future study.
SNPs in MCT1 (show CMA1 Antibodies) and MCT2 genes may affect clinical outcomes and can be used to predict the response to adjuvant chemotherapy in CRC (show CALR Antibodies) patients who received surgical treatment.
MCT2-3' UTR (show UTS2R Antibodies) SNP (+2626 G > A) had a strong association with oligoasthenoteratozoospermia.
this study provided evidence for the presence of MCT2 in prostate cancer, selectively labeling malignant glands.
The monocarboxylate transporter 2 (MCT2) protein was tumor-selectively expressed in human colorectal malignancies and knockdown of MCT2 induces mitochondrial dysfunction, cell-cycle arrest, and senescence.
Light microscopic immunohistochemistry revealed significantly less perivascular MCT2 immunoreactivity in the hippocampal formation in medial temporal lobe epilepsy than in non-MTLE patients
Data show that a significant increase of MCT2 and MCT4 (show SLC16A4 Antibodies) expression in the cytoplasm of tumour cells and a significant decrease in both MCT1 (show CMA1 Antibodies) and CD147 expression in prostate tumour cells was observed when compared to normal tissue.
MCT2 distribution coupled with lactate uptake by hypothalamic neurons suggests that hypothalamic neurons control food intake using lactate to reflect changes in glucose levels.
Data suggest that basigin interacts with MCT1 (show MCTS1 Antibodies) and MCT2 to locate them properly in the membrane of spermatogenic cells and that this may enable sperm to utilize lactate as an energy substrate contributing to cell survival.
Glucose-deprived cleavage stage embryos, undergo oxidative stress and exhibit elevated ROS (show ROS1 Antibodies), which in turn upregulates PPARA (show PPARA Antibodies), catalase (show CAT Antibodies) and SLC16A7 in a classical peroxisomal proliferation response.
These results demonstrate that MCT2 expression can be upregulated together with other key postsynaptic proteins in vivo under conditions related to synaptic plasticity
changes in MCT2 expression could participate in the process of synaptic plasticity induced by BDNF (show BDNF Antibodies)
data provide convincing evidence that MCT2 represents a major neuronal monocarboxylate transporter in the adult mouse brain
In mouse cortical neurons MCT2 is the major monocarboxylate transporter; its expression is correlated with synaptic development.
Regulation of expression of MCT1 (show MCTS1 Antibodies) and MCT2 was investigated in mouse cortical neurons; neither noradrenaline, dibutyryl cAMP nor forskolin affected MCT2 mRNA expression
Noradrenaline induces an increase in neuronal MCT2 protein expression by a mechanism involving stimulation of phosphoinositide 3-kinase/Akt (show AKT1 Antibodies) and translational activation via the mTOR (show FRAP1 Antibodies)/S6 kinase (show RPS6KB1 Antibodies) pathway.
Expression of cerebral MCT (show MCAT Antibodies) isoforms can be modulated by alterations of peripheral metabolism, suggesting that the adult brain is sensitive and adapts to new metabolic states.
immunohistochemical studies localized MCT2, MCT7, and MCT8 (show MCT8 Antibodies) proteins in the cattle rumen, abomasum, jejunum, and caecum.
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants.
monocarboxylate transporter 2
, solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
, MCT 2
, solute carrier family 16 (monocarboxylic acid transporters), member 7
, solute carrier family 16 member 7
, Solute carrier family 16 member 7