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Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 Proteins (SLC16A4)

Proton-linked monocarboxylate transporter. Additionally we are shipping SLC16A4 Antibodies (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC16A4 229699 Q8R0M8
SLC16A4 9122 O15374
Rat SLC16A4 SLC16A4 295356  
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Top SLC16A4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

SLC16A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 (SLC16A4) Interaction Partners

Mouse (Murine) Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 (SLC16A4) interaction partners

  1. This study showed that mouse MCT1 (show MCTS1 Proteins), MCT2, and MCT4 (show SLC16A3 Proteins) are expressed in the PNS. While DRG neurons express MCT1 (show MCTS1 Proteins), myelinating Schwann cells.

  2. Expression of cerebral MCT (show MCAT Proteins) isoforms can be modulated by alterations of peripheral metabolism, suggesting that the adult brain is sensitive and adapts to new metabolic states.

Human Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 (SLC16A4) interaction partners

  1. MCT1 (show CMA1 Proteins) expression was not clearly associated with overall or disease-free survival. MCT4 and CD147 (show BSG Proteins) expression correlate with worse prognosis across many cancer types. These results warrant further investigation of these associations

  2. Prognostic significance of CD147 (show BSG Proteins) protein expression could not surpass that of MCT4, especially of SLC16A3 (show SLC16A3 Proteins) DNA methylation (show HELLS Proteins), corroborating the role of MCT4 as prognostic biomarker for ccRCC.

  3. MCT4 expression is regulated by the PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins) signalling pathway and highly expressed in HER2 (show ERBB2 Proteins)-positive breast cancers where it regulates tumor cell metabolism and survival.

  4. Knockdown of MCT4 blocks lactate efflux to result in lactic acid accumulation and pH dropping, which is involved in triggering apoptosis in HUVECs.

  5. we showed that genetic disruption of Mct4 and/or Ampk (show PRKAA1 Proteins) dramatically reduced tumourigenicity in a xenograft mouse model suggesting a crucial role for these two actors in establishment of tumours in a nutrient-deprived environment

  6. synovial fibroblasts from patients with rheumatoid arthritis exhibited up-regulated transcription of MCT4 mRNA compared with osteoarthritis patients. Knockdown of MCT4 induced intrinsic apoptosis of fibroblasts, thereby inhibiting their proliferation.

  7. The first IF method has been developed and optimised for detection of MCT 1 (show CMA1 Proteins) and MCT4 in cancer patient circulating tumour cells .

  8. Findings demonstrate that the histidine residue His382 in the extracellular loop of the transporter is essential for pH regulation of MCT4-mediated substrate transport activity.

  9. Decreased astroglial monocarboxylate transporter 4 expression in temporal lobe epilepsy

  10. MCT4 expression can predict survival and trans-arterial chemoembolization treatment response for hepatocellular carcinoma patients. MCT4 plays a role in cell proliferation and migration/invasion.

SLC16A4 Protein Profile

Protein Summary

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene names and symbols associated with SLC16A4

  • solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (SLC16A4)
  • solute carrier family 16, member 4 (SLC16A4)
  • solute carrier family 16 (monocarboxylic acid transporters), member 4 (slc16a4)
  • solute carrier family 16 (monocarboxylic acid transporters), member 4 (Slc16a4)
  • solute carrier family 16 (monocarboxylic acid transporters), member 5 (Slc16a5)
  • solute carrier family 16, member 4 (Slc16a4)
  • A130015N09Rik protein
  • AW146050 protein
  • MCT4 protein
  • MCT 5 protein
  • MCT5 protein
  • MCT 6 protein
  • zgc:158390 protein

Protein level used designations for SLC16A4

solute carrier family 16, member 4 (monocarboxylic acid transporter 5) , solute carrier family 16, member 4 , monocarboxylate transporter 5 , monocarboxylate transporter 6 , solute carrier family 16 member 5 , MCT 4 , MCT 5 , monocarboxylate transporter 4 , solute carrier family 16 (monocarboxylic acid transporters), member 4

GENE ID SPECIES
419809 Gallus gallus
479908 Canis lupus familiaris
701535 Macaca mulatta
100058580 Equus caballus
100359220 Oryctolagus cuniculus
469796 Pan troglodytes
567144 Danio rerio
229699 Mus musculus
217316 Mus musculus
9122 Homo sapiens
295356 Rattus norvegicus
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