Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 Proteins (SLC16A4)

Proton-linked monocarboxylate transporter. Additionally we are shipping SLC16A4 Antibodies (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC16A4 229699 Q8R0M8
SLC16A4 9122 O15374
Rat SLC16A4 SLC16A4 295356  
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Top SLC16A4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details

SLC16A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 (SLC16A4) Interaction Partners

Mouse (Murine) Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 (SLC16A4) interaction partners

  1. This study showed that mouse MCT1 (show MCTS1 Proteins), MCT2, and MCT4 (show SLC16A3 Proteins) are expressed in the PNS. While DRG neurons express MCT1 (show MCTS1 Proteins), myelinating Schwann cells.

  2. Expression of cerebral MCT (show MCAT Proteins) isoforms can be modulated by alterations of peripheral metabolism, suggesting that the adult brain is sensitive and adapts to new metabolic states.

Human Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 (SLC16A4) interaction partners

  1. The reversible H(+)/lactate(-) symporter MCT4 cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.

  2. Increased miR (show MLXIP Proteins)-210 and concomitant decreased ISCU (show ISCU Proteins) RNA levels were found in ~40% of tumors and this was significantly associated with HIF-1alpha (show HIF1A Proteins) and CAIX (show CA9 Proteins), but not MCT1 (show CMA1 Proteins) or MCT4, over-expression.

  3. High expression of MCT4 is associated with inflammation in arsenite-induced liver carcinogenesis.

  4. The loss expression of Cav-1 on CAFs and the up-regulation of MCT4 may be the possible mechanisms of CAFs in tumorigenesis.

  5. MCT1 (show CMA1 Proteins) and MCT4 expression levels were associated with worse prognosis and shorter overall survival.

  6. We demonstrated that the expression levels of glycolysis-related proteins glucose transporter 1 (show SLC2A1 Proteins), hexokinase II, carbonic anhydrase IX (show CA9 Proteins), and monocarbonylate transporter 4 differ between thyroid cancer subtypes and are correlated with poorer prognosis

  7. Data suggest that inhibition of mnocarboxylate transporters MCT1 (show CMA1 Proteins) and MCT4 may have clinical relevance in pancreatic ductal adenocarcinoma (PDAC).

  8. MCT1 (show CMA1 Proteins) inhibition impairs proliferation of glycolytic breast cancer cells co-expressing MCT1 (show CMA1 Proteins) and MCT4 via disruption of pyruvate rather than lactate export.

  9. MCT1 (show CMA1 Proteins) expression was not clearly associated with overall or disease-free survival. MCT4 and CD147 (show BSG Proteins) expression correlate with worse prognosis across many cancer types. These results warrant further investigation of these associations

  10. Prognostic significance of CD147 (show BSG Proteins) protein expression could not surpass that of MCT4, especially of SLC16A3 (show SLC16A3 Proteins) DNA methylation (show HELLS Proteins), corroborating the role of MCT4 as prognostic biomarker for ccRCC.

SLC16A4 Protein Profile

Protein Summary

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene names and symbols associated with SLC16A4

  • solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (SLC16A4)
  • solute carrier family 16, member 4 (SLC16A4)
  • solute carrier family 16 (monocarboxylic acid transporters), member 4 (slc16a4)
  • solute carrier family 16 (monocarboxylic acid transporters), member 4 (Slc16a4)
  • solute carrier family 16 (monocarboxylic acid transporters), member 5 (Slc16a5)
  • solute carrier family 16, member 4 (Slc16a4)
  • A130015N09Rik protein
  • AW146050 protein
  • MCT4 protein
  • MCT 5 protein
  • MCT5 protein
  • MCT 6 protein
  • zgc:158390 protein

Protein level used designations for SLC16A4

solute carrier family 16, member 4 (monocarboxylic acid transporter 5) , solute carrier family 16, member 4 , monocarboxylate transporter 5 , monocarboxylate transporter 6 , solute carrier family 16 member 5 , MCT 4 , MCT 5 , monocarboxylate transporter 4 , solute carrier family 16 (monocarboxylic acid transporters), member 4

GENE ID SPECIES
419809 Gallus gallus
479908 Canis lupus familiaris
701535 Macaca mulatta
100058580 Equus caballus
100359220 Oryctolagus cuniculus
469796 Pan troglodytes
567144 Danio rerio
229699 Mus musculus
217316 Mus musculus
9122 Homo sapiens
295356 Rattus norvegicus
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