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Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells.
depolarization-induced hyperacidification is mediated by the vesicular glutamate transporter 2 (VGLUT).
The data of this study indicated that the Grpr (show GRPR Antibodies)-Cre spinal cord neural population is composed of interneurons that use VGLUT2-mediated signaling for transmitting chemical and spontaneous itch stimuli to the next, currently unknown, neurons in the labeled line of itch.
Data show that activation of nucleotide receptor P2Y4 (P2Y4 (show P2RY4 Antibodies)) in the differentiating embryonic stem cells (ESCs (show NR2E3 Antibodies)) resulted in an increased proportion of neurons expressing vesicular glutamate transporter (show SLC1A1 Antibodies) (vGluT).
Study detected increased expression levels of the vesicular glutamate transporter 2 in motor cortex Layer V of G93A (Amyotrophic lateral sclerosis) mice.
Male, but not female, mice lacking vGlut2 in POMC (show POMC Antibodies) neurons were unable to maintain energy balance to the same extent as control mice.
Distribution of VGLUT1 (show SLC17A7 Antibodies) and VGLUT2 in the CN, previously described for guinea pig, was replicated in mouse and showed similar changes in VGLUT1 (show SLC17A7 Antibodies) and 2 distributions after unilateral cochlear insult
These results demonstrate that changes in the expression of supraspinal VGLUT2 may be a new mechanism relevant to the induction of neuropathic pain after nerve injury that acts through an aggravation of glutamate (show GRIN1 Antibodies) imbalance.
Results suggest that both embryonal and adolescent forebrain expression of Vglut2 in mice normally contributes to balancing the level of anxiety.
Data shows that VGLUT2-mediated glutamatergic transmission from Trpv1 (show TRPV1 Antibodies)-Cre neurons selectively mediates heat and mechanical hypersensitivity associated with nerve injury.
This study showed the the Vglut2 gene expression within all three VTA-VGLUT2 populations identified in the medial aspects of the A10 area and related to spatial memory.
This study demonstrated that Protein levels of vGLUT2 were significantly increased in schizophrenia subjects compared to controls.
Vglut2 and oligodendrocyte progenitor cells co-localize in multiple sclerosis lesions, supporting evidence that neuronal activity and release of glutamate (show GRIN1 Antibodies) instruct OPCs to differentiate into new myelinating oligodendrocytes that recover lost function.
Itch is regulated by VGLUT2-mediated transmission in neurons via Trpv1 (show TRPV1 Antibodies).
There is a glutamatergic signal from ventral tegmental area VGluT2-habenular neurons that plays a role in aversive conditioning.
This study demonistrated that Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex(V1 area)
Data indicate that GABAergic axons were labeled with vesicular inhibitory aa transporter (VIAAT (show SLC32A1 Antibodies)) antibodies, whereas glutamatergic axons were detected with antisera against the major vesicular glutamate transporter (show SLC1A1 Antibodies) (VGLUT) isoforms, VGLUT1 (show SLC17A7 Antibodies) and VGLUT2.
This study may lend support to the multiple rare mutations hypothesis of schizophrenia, and may provide genetic clues to indicate the involvement of the glutamate (show GRIN1 Antibodies) transmission pathway in the pathogenesis of schizophrenia.
Our results suggest that VGLUT1 (show SLC17A7 Antibodies) expression in the prefrontal cortex could be used as a valuable neurochemical marker of dementia in AD.
Docking and homology modeling explain the inhibition of VGLUT2.
Vesicular glutamate transporter 2 was unchanged at both levels of gene expression.
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
vesicular glutamate transporter 2
, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
, glutamate transporter
, vesicular glutamate transporter 2-like
, differentiation-associated BNPI
, differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
, solute carrier family 17 (vesicular glutamate transporter), member 6
, solute carrier family 17 member 6
, solute carrier family 17, member 6
, differentiation-associated Na-dependent inorganic phosphate cotransporter
, differentation-associated Na-dependent inorganic phosphate cotransporter