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The protein encoded by SLC17A7 is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain.
Vesicular glutamate transporter 3 (show SLC17A8 Antibodies) is expressed preferentially in hair cells of the ear, and is required for synaptic transmission in the hair cells in zebrafish.
In CA1 (show CA1 Antibodies) pyramidal neurons, a slow excitatory postsynaptic current is absent in the VGLUT1 knockout mouse.
Data show that activation of nucleotide receptor P2Y4 (P2Y4 (show P2RY4 Antibodies)) in the differentiating embryonic stem cells (ESCs (show NR2E3 Antibodies)) resulted in an increased proportion of neurons expressing vesicular glutamate transporter (show SLC1A1 Antibodies) (vGluT).
Results suggest that activation of JNK (show MAPK8 Antibodies) in Alzheimer's disease (AD) inhibits insulin (show INS Antibodies) signaling which could lead to a decreased expression of VGLUT1, therefore contributing to the glutamatergic deficit in AD
Distribution of VGLUT1 and VGLUT2 (show SLC17A6 Antibodies) in the CN, previously described for guinea pig, was replicated in mouse and showed similar changes in VGLUT1 and 2 distributions after unilateral cochlear insult
Here, we show that VGluT1(+/-) mice acquired the initial visual discrimination at the same rate as controls. However, they failed to suppress responses to the previously rewarded stimulus following reversal of reward contingencies.
our genetic analysis provides new in vivo evidence that VGluT1(+) glutamatergic signaling, mediated by the astroglial mGluR5 (show GRM5 Antibodies) receptor, regulates the functional maturation of cortical astroglia during development.
Targeting of VGLUT-1 in the hippocampus leads to cognitive deficits in a knocked-down adult mouse model.
VGLUT1 enhances the tonicity of excitatory synaptic vesicles and stabilises SVs (show FGFR2 Antibodies) at presynaptic terminals.
This study demonstrates a key role for VGLUT1 in long-loop glutamatergic feedback control of 5-HT (show DDC Antibodies) function.
These data indicate that VGluT1, but not VGluT2 (show SLC17A6 Antibodies), plays a role in the neural processes underlying inhibitory learning
Loss of SLC17A7 expression is associated with glioblastoma.
Depressed patients showed significant decreases in synaptophysin (SYN (show SYP Antibodies)) and VGLUT1 expression, whereas in bipolar patients, decreases in VGLUT1 expression have also been found.
Data indicate that GABAergic axons were labeled with vesicular inhibitory aa transporter (VIAAT (show SLC32A1 Antibodies)) antibodies, whereas glutamatergic axons were detected with antisera against the major vesicular glutamate transporter (show SLC1A1 Antibodies) (VGLUT) isoforms, VGLUT1 and VGLUT2 (show SLC17A6 Antibodies).
We examined the ratio of excitatory to inhibitory vesicular neurotransmitter transporter (show SLC6A2 Antibodies) mRNAs (VGluT1 to VGAT (show SLC32A1 Antibodies)) and their ratio in the dorsolateral prefrontal cortex during normal human development and in people with schizophrenia
this study suggests that the common genetic variants of the VGLUT1 gene appear not play a major role in conferring susceptibility to schizophrenia in Han population of Taiwan.
In schizophrenia, VGLUT1 mRNA was decreased in hippocampal formation and dorsolateral prefrontal cortex. In the hippocampus, the loss of VGLUT1 mRNA supports data indicating that glutamatergic presynaptic deficits are prominent.
Alterations in the pattern of vesicular glutamate transporter 1-immunoreactivity that perfectly matched the neuronal loss and gliosis, as well as the decrease in the number of asymmetrical synapses identified by electron microscopy in this tissue
Our results suggest that VGLUT1 expression in the prefrontal cortex could be used as a valuable neurochemical marker of dementia in AD.
Docking and homology modeling explain the inhibition of VGLUT1.
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.
vesicular glutamate transporter 1
, solute carrier family 17 member 7
, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
, vesicular glutamate transporter 1-like
, brain-specific Na(+)-dependent inorganic phosphate cotransporter
, solute carrier family 17, member 7
, brain-specific Na-dependent inorganic phosphate cotransporter
, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
, solute carrier family 17 member 6
, vesicular glutamate transporter 2