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Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteins (SLC22A8)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Antibodies (50) and Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A8 9376 Q8TCC7
Rat SLC22A8 SLC22A8 83500 Q9R1U7
SLC22A8 19879 O88909
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Top Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC22A8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Interaction Partners

Human Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) interaction partners

  1. The putative promoter sequences from hOAT1 (SLC22A6 (show SLC22A6 Proteins)) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.

  2. Findings suggest specific involvement of each organic cation transporters (OCT1 (show POU2F1 Proteins)-3) in drug transportation.

  3. Findings suggest that OCT3 (show POU5F1 Proteins) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.

  4. The markers of EMT (show ITK Proteins) were detected by using Western blot.

  5. PPIs inhibit [(3)H]MTX (show MTX1 Proteins) transport via hOAT3 inhibition.

  6. Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3 (show OCT3 Proteins)) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD (show CHDH Proteins)).

  7. The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.

  8. Pemetrexed is a superior substrate to methotrexate for hOAT3.

  9. Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines partly through OCT3 (show POU5F1 Proteins).

  10. In HEK293-Flp (show HPD Proteins)-In cells, the OAT3-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01].

Mouse (Murine) Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) interaction partners

  1. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (show SLC22A6 Proteins) and OAT3).

  2. Study showed that few, if any, 5-HT (show DDC Proteins) neurons in the dorsal raphe are resistant to loss of Pet-1 (show FEV Proteins) for expression of Slc22a3 (show OCT3 Proteins)

  3. Findings suggest that OCT3 (show POU5F1 Proteins) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.

  4. These results demonstrate that OCT3 (show POU5F1 Proteins) is responsible for metformin accumulation and secretion in salivary glands.

  5. Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.

  6. Oat3 also plays a role in bioenergetic pathways.

  7. At the protein level, mOat3 and mOat1 (show SLC22A6 Proteins) exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 (show SLC22A6 Proteins) is male dominant due to androgen stimulation.

  8. Data indicate that the expression of the organic cation transporters Slc22a1 (show SLC22A1 Proteins), Slc22a2 (show SLC22A2 Proteins) and Slc22a3 (show OCT3 Proteins) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Proteins)+/-renal tumours.

  9. Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.

  10. The results are consistent with a contribution of OAT3 and possibly OAT1 (show SLC22A6 Proteins) to renal creatinine secretion in mice.

Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Protein Profile

Protein Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.

Gene names and symbols associated with SLC22A8

  • solute carrier family 22 (organic anion transporter), member 8 (SLC22A8)
  • solute carrier family 22 (organic anion transporter), member 8 (Slc22a8)
  • solute carrier family 22 (organic cation transporter), member 3 (SLC22A3)
  • solute carrier family 22 (organic cation transporter), member 3 (Slc22a3)
  • EMT protein
  • EMTH protein
  • Oat3 protein
  • Oct3 protein
  • Orct3 protein
  • Roct protein
  • Slca22a3 protein

Protein level used designations for SLC22A8

solute carrier family 22 member 8 , organic anion transporter 3 , hOAT3 , rOat3 , solute carrier family 22 ,member 8 , rbOAT3 , renal organic anion transporter 3 , reduced in osteosclerosis transporter , solute carrier family 22, member 8 , pOAT3 , EMT organic cation transporter 3 , extraneuronal monoamine transporter , organic cation transporter 3 , solute carrier family 22 (extraneuronal monoamine transporter), member 3 , solute carrier family 22 member 3 , solute carrier family 22, member 3

GENE ID SPECIES
451274 Pan troglodytes
100172896 Pongo abelii
9376 Homo sapiens
83500 Rattus norvegicus
476049 Canis lupus familiaris
404128 Bos taurus
100008845 Oryctolagus cuniculus
19879 Mus musculus
407774 Sus scrofa
6581 Homo sapiens
20519 Mus musculus
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