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The protein encoded by SLC22A12 is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. Additionally we are shipping Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Kits (7) and Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Proteins (4) and many more products for this protein.
Showing 10 out of 25 products:
Human Monoclonal SLC22A12 Primary Antibody for ELISA, WB - ABIN530376
Roncal-Jimenez, Lanaspa, Rivard, Nakagawa, Sanchez-Lozada, Jalal, Andres-Hernando, Tanabe, Madero, Li, Cicerchi, Mc Fann, Sautin, Johnson: Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. in Metabolism: clinical and experimental 2011
Show all 2 references for ABIN530376
Human Polyclonal SLC22A12 Primary Antibody for WB - ABIN2781716
Kanai: [Molecular mechanisms of urate transport in renal tubules: localization and function of urate transporters]. in Nihon rinsho. Japanese journal of clinical medicine 2008
Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1 (show SLC2A9 Antibodies), ABCG2 (show ABCG2 Antibodies), and URAT1. Immunostaining for GLUT9 (show SLC2A9 Antibodies) was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 (show ABCG2 Antibodies) was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization.
The cause of obesity/metabolic syndrome-associated hyperuricemia appears to be associated with the urate reabsorption transporter Urat1 protein enhanced by fat.
Although the fractional excretion of urate of knockout mice was tend to higher than that of wildtype mice, the urate reabsorption ability remained in the kidney of knockout mice, indicating a urate reabsorptive transporter other than Urat1.
mouse RST mediates the efflux of organic anions including urate and works as exit for organic anions in the proximal tubules
NHERF-1 (show SLC9A3R1 Antibodies) exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the brush Border membrane abundance of mURAT1.
URAT1 nonfunctional variants are protective genetic factors for gout/hyperuricemia, and also demonstrated the sex-dependent effect size of these URAT1 variants on serum uric acid (P for interaction = 1.5 x 10(-12)).
These results suggest that URAT1 rs3825016 and rs1529909 polymorphisms influence the uricosuric action of losartan
Depletion of UA due to SLC22A12/URAT1 loss-of-function mutations causes endothelial dysfunction in hypouricemia patients.
not only loss-of-function mutation of URAT1 but also the dominant-negative effect cause RHUC through loss of UA absorption, partly due to protein misfolding caused by accumulation of URAT1 protein in the endoplasmic reticulum
Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males.
protein expression of URAT1 and GLUT9 (show SLC2A6 Antibodies) in renal tissues of patients with uric acid (UA) nephrolithiasis
There was no significant mutation found in SLC22A12 and SLC2A9 (show SLC2A9 Antibodies) in this familial aggregation of Chinese female premenopausal gout.
Genetic polymorphisms in the urate transporters SLC2A9 (show SLC2A9 Antibodies), SLC22A12 and non-synonymous allelic variants of GLUT9 (show SLC2A6 Antibodies) showed no evidence of the effect on hyperuricemia and gout in the Czech population.
Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11 (show SLC22A11 Antibodies)/SLC22A12 locus that presumably influence the activity of OAT4 (show SLC22A9 Antibodies) and URAT1 and risk of gout.
Our study is the first one in Turkish population and suggests that there is no association between primary gout disease and SLC22A12 gene polymorphisms.
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.
, solute carrier family 22 (organic cation transporter)-like 2
, solute carrier family 22 member 12
, urate anion exchanger 1
, organic anion transporter 4-like protein
, solute carrier family 22 (organic anion/cation transporter), member 12
, urate transporter 1