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Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Proteins (SLC22A12)

The protein encoded by SLC22A12 is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. Additionally we are shipping Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Antibodies (24) and Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A12 20521 Q8CFZ5
SLC22A12 116085 Q96S37
Rat SLC22A12 SLC22A12 365398 Q3ZAV1
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Top Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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SLC22A12 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) Interaction Partners

Mouse (Murine) Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) interaction partners

  1. The cause of obesity/metabolic syndrome-associated hyperuricemia appears to be associated with the urate reabsorption transporter Urat1 protein enhanced by fat.

  2. Although the fractional excretion of urate of knockout mice was tend to higher than that of wildtype mice, the urate reabsorption ability remained in the kidney of knockout mice, indicating a urate reabsorptive transporter other than Urat1.

  3. mouse RST mediates the efflux of organic anions including urate and works as exit for organic anions in the proximal tubules

  4. NHERF-1 (show SLC9A3R1 Proteins) exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the brush Border membrane abundance of mURAT1.

Human Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) interaction partners

  1. These results suggest that URAT1 rs3825016 and rs1529909 polymorphisms influence the uricosuric action of losartan

  2. Depletion of UA due to SLC22A12/URAT1 loss-of-function mutations causes endothelial dysfunction in hypouricemia patients.

  3. not only loss-of-function mutation of URAT1 but also the dominant-negative effect cause RHUC through loss of UA absorption, partly due to protein misfolding caused by accumulation of URAT1 protein in the endoplasmic reticulum

  4. Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males.

  5. protein expression of URAT1 and GLUT9 in renal tissues of patients with uric acid (UA) nephrolithiasis

  6. There was no significant mutation found in SLC22A12 and SLC2A9 in this familial aggregation of Chinese female premenopausal gout.

  7. Genetic polymorphisms in the urate transporters SLC2A9, SLC22A12 and non-synonymous allelic variants of GLUT9 showed no evidence of the effect on hyperuricemia and gout in the Czech population.

  8. Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11 (show SLC22A11 Proteins)/SLC22A12 locus that presumably influence the activity of OAT4 (show SLC22A9 Proteins) and URAT1 and risk of gout.

  9. Our study is the first one in Turkish population and suggests that there is no association between primary gout disease and SLC22A12 gene polymorphisms.

  10. analysis of mutations in genes SLC22A12 and SLC2A9 urate transporter (show LGALS9 Proteins) genes in patients with exercise-induced acute kidney injury

Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SLC22A12

  • solute carrier family 22 (organic anion/cation transporter), member 12 (Slc22a12)
  • solute carrier family 22 (organic anion/urate transporter), member 12 (SLC22A12)
  • solute carrier family 22 (organic anion/urate transporter), member 12 (Slc22a12)
  • AI987855 protein
  • OAT4L protein
  • RST protein
  • Slc22al2 protein
  • URAT1 protein

Protein level used designations for SLC22A12

renal-specific transporter , solute carrier family 22 (organic cation transporter)-like 2 , solute carrier family 22 member 12 , urate anion exchanger 1 , organic anion transporter 4-like protein , solute carrier family 22 (organic anion/cation transporter), member 12 , urate transporter 1

GENE ID SPECIES
20521 Mus musculus
116085 Homo sapiens
365398 Rattus norvegicus
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