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Solute Carrier Family 22 (Organic Cation Transporter), Member 1 Proteins (SLC22A1)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Cation Transporter), Member 1 Antibodies (66) and Solute Carrier Family 22 (Organic Cation Transporter), Member 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A1 6580 O15245
SLC22A1 20517 O08966
Rat SLC22A1 SLC22A1 24904 Q63089
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Top Solute Carrier Family 22 (Organic Cation Transporter), Member 1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

SLC22A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) Interaction Partners

Human Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) interaction partners

  1. This study indicates a promising role for intratumoral OCT1 (show POU2F1 Proteins) mRNA expression as a prognostic biomarker in therapeutic algorithms in HCC (show FAM126A Proteins)

  2. Data show that bisindolylmaleimides (BIMs) Ro 31-8220 also blocks activity of the solute carrier organic cation transporter 1 (OCT1), involved in uptake of marketed drugs in the liver, in a protein kinase C (PKC)-independent manner.

  3. Homozygous carriers of the polymorphic OCT1 (show POU2F1 Proteins) C-allele had no metformin-related toxicity as compared with 41.9% for any metformin-related toxicity in carriers of at least one wild-type A-allele

  4. A positive association was observed between the expression of the ABCB1 (show ABCB1 Proteins) and ABCG2 transporter genes (r=0.407, P<0.05) while no association was observed between the expression of either of the ABC transporter genes with the OCT1 (show POU2F1 Proteins) gene

  5. Data indicate no association was found between genotypes of drug transporters ABCB1 (show ABCB1 Proteins), ABCG2, OCT1 (show POU2F1 Proteins) genetic polymorphisms and the occurrence of thrombocytopenia.

  6. Findings suggest specific involvement of each organic cation transporters (OCT1 (show POU2F1 Proteins)-3) in drug transportation.

  7. Our data suggest that besides bodyweight, OCT1 (show POU2F1 Proteins) and ABCC3 (show ABCC3 Proteins) genotypes play a significant role in the pharmacokinetics of intravenous morphine and its metabolites in children

  8. Nucleoside transporters and human OCT1 (show POU2F1 Proteins) determine the cellular handling of DNA-methyltransferase (show DNMT1 Proteins) inhibitors

  9. The hOCT1 expression level can be an important predictor in CML patients treated with IM.

  10. OCT1 (show POU2F1 Proteins) plays a significant role in hepatic elimination of serotonin at the transporter level.

Cow (Bovine) Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) interaction partners

  1. Dopamine transport across the olfactory and respiratory mucosae is partially mediated by organic cation transporters, including OCT-1 (show POU2F1 Proteins) and OCT-2 (show SLC22A2 Proteins).

Mouse (Murine) Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) interaction partners

  1. Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 (show SLC22A2 Proteins) and Slc22a3 (show OCT3 Proteins) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Proteins)+/-renal tumours.

  2. Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.

  3. The influence of organic cation transporters 1, 2, and 3 (OCT1 (show POU2F1 Proteins), OCT2 (show SLC22A2 Proteins), and OCT3 (show POU5F1 Proteins)) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation, was determined.

  4. Oct1 (show POU2F1 Proteins) forms repeating, cyclosporin-sensitive regulatory modules within the CD21 (show CR2 Proteins) intronic control region.

  5. a comparison of the transport properties of Oct2 (show SLC22A2 Proteins) and Oct1 (show POU2F1 Proteins)

  6. oct1 (show POU2F1 Proteins) has a role in controlling fgl2 (show FGL2 Proteins) expression in endothelial cells

  7. This study shows that Oct1 (show POU2F1 Proteins) and Oct2 (show SLC22A2 Proteins) together are essential for renal secretion of (small) organic cations.

  8. nuclear factor Y and Oct-1 bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated expression of the mGnRH receptor gene

  9. The purpose of this study was to examine the effects of peroxisome proliferator agonist receptor agonists on the hepatic regulation and function of Slc22a1.

  10. a multiprotein complex containing GATA-1, Oct-1, and other protein factors may contribute to the formation of a repressive chromatin structure that silences gamma-globin gene expression

Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) Protein Profile

Protein Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.

Gene names and symbols associated with SLC22A1

  • solute carrier family 22 (organic cation transporter), member 1 (SLC22A1)
  • organic cation transporter 1 (OCT1)
  • renal organic cation transporter (RBOCT1)
  • solute carrier family 22 (organic cation transporter), member 1 (Slc22a1)
  • solute carrier family 22 member 2-like (LOC421584)
  • HOCT1 protein
  • Lx1 protein
  • Oct1 protein
  • oct1_cds protein
  • Orct protein
  • Orct1 protein
  • Roct1 protein
  • SLC22A1 protein
  • SLC22A2 protein

Protein level used designations for SLC22A1

solute carrier family 22 member 1 , solute carrier family 22 (organic cation transporter), member 1 , solute carrier family 22 member 1-like , pOCT1 , organic cation transporter 1 , mOCT1 , solute carrier family 22, member 1 , solute carrier family 22 (organic cation transporter), member 2

GENE ID SPECIES
472177 Pan troglodytes
100027984 Monodelphis domestica
100412933 Callithrix jacchus
100436901 Pongo abelii
397049 Sus scrofa
100008659 Oryctolagus cuniculus
6580 Homo sapiens
484068 Canis lupus familiaris
519461 Bos taurus
20517 Mus musculus
24904 Rattus norvegicus
421584 Gallus gallus
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