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Solute Carrier Family 22 (Organic Cation Transporter), Member 11 (SLC22A11) ELISA Kits

The protein encoded by SLC22A11 is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. Additionally we are shipping SLC22A11 Antibodies (19) and SLC22A11 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SLC22A11 SLC22A11 55867 Q9NSA0
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More ELISA Kits for SLC22A11 Interaction Partners

Human Solute Carrier Family 22 (Organic Cation Transporter), Member 11 (SLC22A11) interaction partners

  1. The regulation of hOAT4 activity was mediated by sgk2 acting through Nedd4-2.

  2. SLC22A11 at the basal plasma membrane of human placental syncytiotrophoblasts plays a predominant role in the uptake of 16alpha-OH DHEAS (show SULT2A1 ELISA Kits) for placental estriol synthesis.

  3. Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11/SLC22A12 (show SLC22A12 ELISA Kits) locus that presumably influence the activity of OAT4 and URAT1 (show SLC22A12 ELISA Kits) and risk of gout.

  4. When investigating the genes separately, SLC22A11 and SLC2A9 (show SLC2A9 ELISA Kits) showed a significant interaction, consistent with the former encoding an organic anion/dicarboxylate exchanger, which mediates diuretic transport in the kidney.

  5. Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.

  6. The down-regulation of hOAT4 activity by activation of protein kinase C and the up-regulation of hOAT4 activity by NHERF-1 are mediated through alteration of hOAT4 internalization.

  7. Glycosylation serves as a means to specifically regulate hOAT4 function in vivo.

  8. hOAT4 is the long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia.

  9. The interaction of PDZ proteins with hOAT4 may be cell-specific. In placenta, a different set of interacting proteins from PDZK1 and NHERF1 may be required to modulate hOAT4 activity.

  10. The present study demonstrates that hOAT4 variants can causing inter-individual variation in anionic drug uptake and, therefore, could be used as markers for certain diseases including osteoporosis.

SLC22A11 Antigen Profile

Antigen Summary

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.

Gene names and symbols associated with SLC22A11

  • solute carrier family 22 (organic anion/urate transporter), member 11 (SLC22A11) antibody
  • solute carrier family 22 member 11 (LOC100349650) antibody
  • DKFZp469L1732 antibody
  • hOAT4 antibody
  • OAT4 antibody

Protein level used designations for SLC22A11

solute carrier family 22 (organic anion/urate transporter), member 11 , solute carrier family 22 member 11 , solute carrier family 22 (organic anion/cation transporter), member 11 , organic anion transporter 4

GENE ID SPECIES
466654 Pan troglodytes
699212 Macaca mulatta
100174235 Pongo abelii
100349650 Oryctolagus cuniculus
55867 Homo sapiens
518926 Bos taurus
612103 Canis lupus familiaris
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