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Solute Carrier Family 22 (Organic Cation Transporter), Member 11 Proteins (SLC22A11)

The protein encoded by SLC22A11 is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. Additionally we are shipping SLC22A11 Antibodies (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A11 55867 Q9NSA0
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Top SLC22A11 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

SLC22A11 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Solute Carrier Family 22 (Organic Cation Transporter), Member 11 (SLC22A11) Interaction Partners

Human Solute Carrier Family 22 (Organic Cation Transporter), Member 11 (SLC22A11) interaction partners

  1. The regulation of hOAT4 (show SLC22A9 Proteins) activity was mediated by sgk2 (show SGK2 Proteins) acting through Nedd4-2 (show NEDD4L Proteins).

  2. SLC22A11 at the basal plasma membrane of human placental syncytiotrophoblasts plays a predominant role in the uptake of 16alpha-OH DHEAS (show SULT2A1 Proteins) for placental estriol synthesis.

  3. Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11/SLC22A12 (show SLC22A12 Proteins) locus that presumably influence the activity of OAT4 (show SLC22A9 Proteins) and URAT1 (show SLC22A12 Proteins) and risk of gout.

  4. When investigating the genes separately, SLC22A11 and SLC2A9 showed a significant interaction, consistent with the former encoding an organic anion/dicarboxylate exchanger, which mediates diuretic transport in the kidney.

  5. Genetic variants of human organic anion transporter 4 (show SLC22A9 Proteins) demonstrate altered transport of endogenous substrates.

  6. The down-regulation of hOAT4 (show SLC22A9 Proteins) activity by activation of protein kinase C and the up-regulation of hOAT4 (show SLC22A9 Proteins) activity by NHERF-1 (show SLC9A3R1 Proteins) are mediated through alteration of hOAT4 (show SLC22A9 Proteins) internalization.

  7. Glycosylation serves as a means to specifically regulate hOAT4 (show SLC22A9 Proteins) function in vivo.

  8. hOAT4 (show SLC22A9 Proteins) is the long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia.

  9. The interaction of PDZ proteins with hOAT4 (show SLC22A9 Proteins) may be cell-specific. In placenta, a different set of interacting proteins from PDZK1 (show PDZK1 Proteins) and NHERF1 (show SLC9A3R1 Proteins) may be required to modulate hOAT4 (show SLC22A9 Proteins) activity.

  10. The present study demonstrates that hOAT4 (show SLC22A9 Proteins) variants can causing inter-individual variation in anionic drug uptake and, therefore, could be used as markers for certain diseases including osteoporosis.

SLC22A11 Protein Profile

Protein Summary

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.

Gene names and symbols associated with SLC22A11

  • solute carrier family 22 (organic anion/urate transporter), member 11 (SLC22A11)
  • solute carrier family 22 member 11 (LOC100349650)
  • DKFZp469L1732 protein
  • hOAT4 protein
  • OAT4 protein

Protein level used designations for SLC22A11

solute carrier family 22 (organic anion/urate transporter), member 11 , solute carrier family 22 member 11 , solute carrier family 22 (organic anion/cation transporter), member 11 , organic anion transporter 4

GENE ID SPECIES
466654 Pan troglodytes
699212 Macaca mulatta
100174235 Pongo abelii
100349650 Oryctolagus cuniculus
55867 Homo sapiens
518926 Bos taurus
612103 Canis lupus familiaris
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