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Solute Carrier Family 22 (Organic Cation Transporter), Member 2 (SLC22A2) ELISA Kits

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Cation Transporter), Member 2 Antibodies (74) and Solute Carrier Family 22 (Organic Cation Transporter), Member 2 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SLC22A2 SLC22A2 6582 O15244
Anti-Mouse SLC22A2 SLC22A2 20518 O70577
Anti-Rat SLC22A2 SLC22A2 29503 Q9R0W2
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More ELISA Kits for Solute Carrier Family 22 (Organic Cation Transporter), Member 2 Interaction Partners

Human Solute Carrier Family 22 (Organic Cation Transporter), Member 2 (SLC22A2) interaction partners

  1. Seventeen of the variants observed in the SLC22A2 gene of the Xhosa population were specific to/or occurred at a higher frequency in African populations or populations with a recent connection to the African continent.

  2. We noted a statistically significant association between the nonsynonymous SNP rs316019(SLC22A2) and cisplatin-induced ototoxicity, in that the T allele occurred more frequently in patients who experienced no ototoxicity from cisplatin treatment.

  3. the loss-of-function variant OCT2-T201M (rs145450955) contribute to changes in insulin (show INS ELISA Kits) resistance and beta cell activity in patients with T2D treated with metformin.

  4. The 808G>T variant of SLC22A2 improves the metformin long-term glucose-lowering effect in Chinese type 2 diabetics.

  5. functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2

  6. Findings suggest specific involvement of each organic cation transporters (OCT1 (show POU2F1 ELISA Kits)-3) in drug transportation.

  7. The functional OCT2 Ser270Ala polymorphism is significantly associated with abstinence among treatment-seeking smokers.

  8. Clopidogrel/clopidogrel carboxylate are weak inhibitors of OCT2.

  9. The genetic polymorphisms in OCT2, AQP2 (show AQP2 ELISA Kits), AQP9 (show AQP7 ELISA Kits) and TMEM205 (show TMEM205 ELISA Kits) may contribute to chemotherapy response in lung cancer patients.

  10. In chemotherapy for oesophageal cancers, cisplatin-induced nephrotoxicity seems to be unaffected by SLC22A2 polymorphism

Cow (Bovine) Solute Carrier Family 22 (Organic Cation Transporter), Member 2 (SLC22A2) interaction partners

  1. OCTN2 (show SLC22A5 ELISA Kits) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha (show PPARA ELISA Kits).

  2. Gene expression of the carnitine transporter OCTN2 (show SLC22A5 ELISA Kits) and carnitine transport are regulated by PPARbeta (show PPARD ELISA Kits)/delta in bovine cells.

Mouse (Murine) Solute Carrier Family 22 (Organic Cation Transporter), Member 2 (SLC22A2) interaction partners

  1. Findings identify OCT2 as a genetic factor that directly impacts on the molecular and hormonal events taking place during acute stress, accentuating the noxious effects of repeated stress on the development of stress-related phenotypes

  2. Molecular components of the circadian clock regulated the renal expression of Slc22a2, which resulted in rhythmic oscillations in OCT2 protein levels.

  3. Cellular uptake of oxaliplatin increases by 16- to 35-fold in cells overexpressing Oct2, a process associated with increased DNA platination and oxaliplatin-induced cytotoxicity.

  4. Data indicate that the expression of the organic cation transporters Slc22a1 (show SLC22A1 ELISA Kits), Slc22a2 and Slc22a3 (show OCT3 ELISA Kits) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 ELISA Kits)+/-renal tumours.

  5. findings identify OCT2 as an important postsynaptic determinant of aminergic tonus and mood-related behaviors.

  6. Slc22a2 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele.

  7. OCT1 (show POU2F1 ELISA Kits) and OCT2 are important for N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (show PTPN2 ELISA Kits)) transfer across the blood-brain barrier and amantadine reduces the blood-brain barrier transfer of MPTP (show PTPN2 ELISA Kits) and MPTP (show PTPN2 ELISA Kits)-induced dopaminergic toxicity in rodents.

  8. a comparison of the transport properties of Oct2 and Oct1 (show POU2F1 ELISA Kits)

  9. This study shows that Oct1 (show POU2F1 ELISA Kits) and Oct2 together are essential for renal secretion of (small) organic cations.

  10. The carboxy-terminal activation domain of Oct-2 is required to mediate the unique and indispensable functions of the Oct-2 transcription factor in vivo.

Solute Carrier Family 22 (Organic Cation Transporter), Member 2 (SLC22A2) Antigen Profile

Antigen Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.

Gene names and symbols associated with SLC22A2

  • POU-domain protein (OCT2) antibody
  • solute carrier family 22 (organic cation transporter), member 2 (SLC22A2) antibody
  • solute carrier family 22 (organic cation transporter), member 2 (Slc22a2) antibody
  • Oct2 antibody
  • OCT2P antibody
  • OCT2r antibody
  • Orct2 antibody
  • Pou2f2 antibody
  • rOCT2 antibody

Protein level used designations for SLC22A2

OTF-2 , POU domain, class 2, transcription factor 2 , lymphoid-restricted immunoglobulin octamer-binding protein NF-A2 , oct-2 , octamer-binding protein 2 , octamer-binding transcription factor 2 , organic cation transporter 2 , solute carrier family 22 member 2 , apical organic cation transporter , solute carrier family 22, member 2

GENE ID SPECIES
397105 Sus scrofa
6582 Homo sapiens
396936 Sus scrofa
521027 Bos taurus
100008831 Oryctolagus cuniculus
20518 Mus musculus
29503 Rattus norvegicus
403655 Canis lupus familiaris
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