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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Antibodies (53) and Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Kits (3) and many more products for this protein.
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SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.
The genotype of rs3088442 within the SLC22A3-LPAL2-LPA gene cluster may contribute to regulation of plasma Lp(a) levels and possibly to the severity of coronary artery disease in a Chinese Han population.
Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (show KCNK3 Proteins)/OAT3.
The putative promoter sequences from hOAT1 (SLC22A6 (show SLC22A6 Proteins)) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.
Findings suggest specific involvement of each organic cation transporters (OCT1 (show POU2F1 Proteins)-3) in drug transportation.
Findings suggest that OCT3 (show POU5F1 Proteins) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.
The markers of EMT (show ITK Proteins) were detected by using Western blot.
PPIs inhibit [(3)H]MTX (show MTX1 Proteins) transport via hOAT3 inhibition.
Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3 (show OCT3 Proteins)) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD (show CHDH Proteins)).
The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.
OAT1 (show SLC22A6 Proteins) plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney
Metformin undergoes negligible metabolism, these results imply that intestinal absorption of metformin is mediated at least in part by Oct3 (show POU5F1 Proteins) in mice.
Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (show SLC22A6 Proteins) and OAT3).
Study showed that few, if any, 5-HT (show DDC Proteins) neurons in the dorsal raphe are resistant to loss of Pet-1 (show FEV Proteins) for expression of Slc22a3 (show OCT3 Proteins)
These results demonstrate that OCT3 (show POU5F1 Proteins) is responsible for metformin accumulation and secretion in salivary glands.
Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.
Oat3 also plays a role in bioenergetic pathways.
At the protein level, mOat3 and mOat1 (show SLC22A6 Proteins) exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 (show SLC22A6 Proteins) is male dominant due to androgen stimulation.
Data indicate that the expression of the organic cation transporters Slc22a1 (show SLC22A1 Proteins), Slc22a2 (show SLC22A2 Proteins) and Slc22a3 (show OCT3 Proteins) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Proteins)+/-renal tumours.
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.
solute carrier family 22 member 8
, organic anion transporter 3
, solute carrier family 22 ,member 8
, renal organic anion transporter 3
, reduced in osteosclerosis transporter
, solute carrier family 22, member 8
, EMT organic cation transporter 3
, extraneuronal monoamine transporter
, organic cation transporter 3
, solute carrier family 22 (extraneuronal monoamine transporter), member 3
, solute carrier family 22 member 3
, solute carrier family 22, member 3