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The protein encoded by SLC22A9 is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 9 Antibodies (4) and many more products for this protein.
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Pravastatin is the first identified OAT7 drug substrate. Substantial inter-individual variability in hepatic OAT7 expression, majorly driven by HNF4alpha (show HNF4A Proteins), may contribute to pravastatin drug disposition and might affect response.
uptake of steroid sulfates by isolated trophoblasts is mediated by OATP-B (show SLCO2B1 Proteins) and OAT-4 suggesting a physiological role of both carrier proteins in placental uptake of fetal-derived steroid sulfates.
Both progesterone and activation of PKC (show PRRT2 Proteins) inhibited hOAT4 activity through redistribution of the transporter from cell surface to the intracellular compartments.
OAT7 is the first liver-specific transporter (show SLC22A7 Proteins) among members of the organic anion transporters of SLC22 family.
The data provide a model for the concerted action of OAT1 (show KCNK3 Proteins) mediating apical secretion of glutarate derivatives from proximal tubule cells
The regulatory single nucleotide polymorphism (SNP) of OAT4 found in the promoter region of nephrectomized patients is unlikely to influence mRNA expression or promoter activity of OAT4.
Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of solute carrier (show SERTAD2 Proteins) family (SLC22) member 9.
Functional differences in steroid uptake of SLC22A9 and SLC02B1 in human placenta are reported.
Human organic anion transporter (show SLC22A6 Proteins) hOAT4 is a transporter of perfluorooctanoic acid.
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.
organic anion transporter 4
, organic anion transporter 7
, solute carrier family 22 (organic anion/cation transporter), member 9
, solute carrier family 22 member 9
, solute carrier family 22, member 25