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Solute Carrier Family 22 Member 4 Proteins (SLC22A4)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping SLC22A4 Antibodies (30) and SLC22A4 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A4 30805 Q9Z306
SLC22A4 6583 Q9H015
Rat SLC22A4 SLC22A4 64037 Q9R141
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Top SLC22A4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC22A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for Solute Carrier Family 22 Member 4 (SLC22A4) Interaction Partners

Mouse (Murine) Solute Carrier Family 22 Member 4 (SLC22A4) interaction partners

  1. OCTN1 is functionally expressed on activated intestinal macrophages, and ergothioneine uptake into these immune cells could contribute at least in part to the altered disposition of ergothioneine in intestinal inflammation.

  2. The bile acids that accumulated in intestinal epithelial cells suppressed PPARalpha (show PPARA Proteins)-mediated transactivation of Octn1 in the dark phase.

  3. OCTN1 is involved in cellular differentiation, but inhibits their proliferation, possibly via the regulation of cellular oxidative stress

  4. These results indicate that OCTN1 plays a pivotal role for maintenance of systemic and intestinal exposure of ergothioneine

  5. antibody raised to an epitope during C. jejuni or M. paratuberculosis enterocolitis may crossreact with an intestinal epithelial cell functional variant of OCTN1, an already less efficient carnitine transporter, initiating inflammatory bowel disease

  6. OCTN1 mitochondrial localization was confirmed by Transmission Electron Microscopy of heart.

  7. Octn1 is expressed throughout the CNS with a pattern suggestive of roles in cerebral bioenergetics and in acetylcholine generation for neurotransmission in olfactory, satiety, limbic, memory, motor and sensory functions.

  8. Octn1, -2, and -3 are expressed in many regions of murine heart

Human Solute Carrier Family 22 Member 4 (SLC22A4) interaction partners

  1. These data reveal a role of OCTN1 in transporting acetylcholine and choline in HeLa cells.

  2. mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss.

  3. SLC22A4 was associated with joint erosion in not-very-longstanding RA, although RA susceptibility association was weak and its clinical significance was uncertain.

  4. Functional expression of OCTN1 was confirmed in LPS-stimulated human macrophage-like cell line, THP-1.

  5. This meta-analysis demonstrates that the SLC22A4 F1 polymorphism is associated with susceptibility to RA in East Asians, but not in Europeans.

  6. Report functional/molecular effects of mercury compounds on the human OCTN1 cation transporter: C50 and C136 are the targets for potent inhibition.

  7. A lack of association between the SLC22A4 gene polymorphism rs3792876 and susceptibility to autoimmune thyroid diseases in a Chinese Han population.

  8. SLC22A4 gene polymorphisms played important roles in the etiology of rheumatoid arthritis in the Chinese population.

  9. Single nucleotide polymorphisms in SLC22A4 gene is associated with inborn errors of metabolism.

  10. The selenoneine-mediated OCTN1 system regulates secretory lysosomal vesicle formation and MeHg demethylation.

SLC22A4 Protein Profile

Protein Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.

Gene names and symbols associated with SLC22A4

  • solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (slc22a4)
  • solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (SLC22A4)
  • Solute carrier family 22 member 4 (s22a4)
  • solute carrier family 22 (organic cation transporter), member 4 (Slc22a4)
  • solute carrier family 22 (organic cation/zwitterion transporter), member 4 (SLC22A4)
  • solute carrier family 22 (organic cation/zwitterion transporter), member 4 (Slc22a4)
  • OCTN1 protein
  • SLC22A4 protein
  • zgc:66036 protein

Protein level used designations for SLC22A4

solute carrier family 22 member 4 , solute carrier family 22 member 5 , solute carrier family 22 (organic cation/ergothioneine transporter), member 4 , solute carrier family 22 (organic cation transporter), member 4 , Solute carrier family 22 member 4 , LSTP-Like 2 , organic cation transporter 1 , organic cation/carnitine transporter 1 , solute carrier family (organic cation transporter), member 4 , solute carrier family 22, member 4 , ET transporter , ergothioneine transporter , integral membrane transport protein , organic cation transporter OCTN1

GENE ID SPECIES
393822 Danio rerio
743741 Pan troglodytes
100195081 Salmo salar
30805 Mus musculus
100137217 Papio anubis
6583 Homo sapiens
64037 Rattus norvegicus
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