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Solute Carrier Family 22 Member 5 Proteins (SLC22A5)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping SLC22A5 Antibodies (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A5 20520 Q9Z0E8
SLC22A5 6584 O76082
Rat SLC22A5 SLC22A5 29726 O70594
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Top SLC22A5 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC22A5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
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More Proteins for Solute Carrier Family 22 Member 5 (SLC22A5) Interaction Partners

Mouse (Murine) Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. There was increased apoptosis in gut (show GUSB Proteins) samples from OCTN2(-/-) mice.

  2. Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma (show PPARG Proteins) in humans and mice and contributes to local and systemic carnitine homeostasis.

  3. OCTN2, a transporter that is thought to be responsible for the accumulation of L-carnitine in the epididymal lumen, is regulated in response to changes in tonicity.

  4. Mouse OCTN2 is a direct target gene of PPARalpha (show PPARA Proteins) and transcriptional upregulation of OCTN2 by PPARalpha (show PPARA Proteins) is likely mediated via PPRE1 in its first intron.

  5. acetyl-L-carnitine is transported from blood to brain extracellular fluid by OCTN2

  6. placental OCTN2 is obligatory for accumulation of carnitine in placenta & fetus, fatty acid beta-oxidation enzymes are expressed in placenta & reduced carnitine levels upregulate expression of short-chain L-3-hydroxyacyl CoA dehydrogenase (show HSD17B10 Proteins) in placenta

  7. Novel OCTN2 in mouse pancreas.

  8. OCTN2 functions as a carnitine transporter between the epithelium and the lumen in distal corpus and cauda epididymides and provides a clue as to why obstructive azoospermia is induced in distal parts of epididymis.

  9. These findings indicate that OCTN2 is predominantly responsible for the uptake of carnitine from the apical surface of mouse small intestinal epithelial cells.

  10. PPAR alpha (show PPARA Proteins)-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation

Human Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. The results of the current study demonstrated that -207C>G polymorphism of the SLC22A5 gene is not associated with male infertility.

  2. c.760C>T (p.R254X) mutation of the SLC22A5 gene is associated with the primary carnitine deficiency.

  3. Human OCTN2 expression is directly regulated by PPAR-alpha (show PPARA Proteins).

  4. Nine novel SLC22A5 gene mutations were identified and characterized in Chinese patients with Systemic primary carnitine deficiency CDSP. The R254X mutation was the most frequent, and it could likely be an ethnic founder mutation.

  5. Mutation analysis of the gene SLC22A5 confirms the diagnosis of primary systemic carnitine deficiency.

  6. OCTN2 is involved in L-carnitine transport at the human BBB.

  7. Mutations in SLC22A5 and ETFDH (show ETFDH Proteins) are associated with riboflavin responsive-multiple acyl-CoA dehydrogenase (show ACADM Proteins) deficiency.

  8. promoter methylation is responsible for epigenetic down-regulation of OCTN2 in HepG2 and LS174T cells.

  9. The OCTN2 transporter is generally down-regulated in virus and nonvirus-mediated epithelial cancers, probably via methylation of its promoter region.

  10. Besides the dramatic decrease of free carnitine, carnitine ester metabolism is affected in OCTN2 deficiency in a family with a deletion of 844C of the SLC22A5 gene

Cow (Bovine) Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. Dopamine transport across the olfactory and respiratory mucosae is partially mediated by organic cation transporters, including OCT-1 (show POU2F1 Proteins) and OCT-2 (show SLC22A2 Proteins). OCT-2 (show SLC22A2 Proteins) was localized in the epithelial and submucosal regions of the nasal olfactory and respiratory mucosa

SLC22A5 Protein Profile

Protein Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.

Gene names and symbols associated with SLC22A5

  • solute carrier family 22 (organic cation/carnitine transporter), member 5 (SLC22A5)
  • solute carrier family 22 (organic cation transporter), member 5 (SLC22A5)
  • organic cation/carnitine transporter 2 (2-Oct)
  • solute carrier family 22 (organic cation transporter), member 5 (Slc22a5)
  • solute carrier family 22 (organic cation/carnitine transporter), member 5 (Slc22a5)
  • ATOCT2 protein
  • CDSP protein
  • CT1 protein
  • jvs protein
  • Lstpl protein
  • OCT2 protein
  • Octn2 protein
  • OCTN2VT protein
  • organic cation/carnitine transporter 2 protein
  • ORGANIC CATION TRANSPORTER 2 protein
  • UST2r protein
  • YUP8H12R.2 protein
  • YUP8H12R_2 protein

Protein level used designations for SLC22A5

solute carrier family 22 member 5 , organic cation/carnitine transporter 2 , solute carrier family 22 (organic cation/carnitine transporter), member 5 , solute carrier family 22, member 5 , high-affinity sodium-dependent carnitine cotransporter , juvenile visceral steatosis , high-affinity sodium dependent carnitine cotransporter , high-affinity carnitine transporter , integral membrane transport protein , solute carrier family 22 (organic cation transporter), member 5

GENE ID SPECIES
100072871 Equus caballus
416328 Gallus gallus
100137218 Papio anubis
100358417 Oryctolagus cuniculus
844274 Arabidopsis thaliana
20520 Mus musculus
6584 Homo sapiens
29726 Rattus norvegicus
608146 Canis lupus familiaris
100520422 Sus scrofa
541266 Bos taurus
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