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Solute Carrier Family 22 Member 6 Proteins (SLC22A6)

The protein encoded by SLC22A6 is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. Additionally we are shipping Solute Carrier Family 22 Member 6 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A6 9356 Q4U2R8
SLC22A6 18399 Q8VC69
Rat SLC22A6 SLC22A6 29509 O35956
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Top Solute Carrier Family 22 Member 6 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC22A6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Solute Carrier Family 22 Member 6 (SLC22A6) Interaction Partners

Human Solute Carrier Family 22 Member 6 (SLC22A6) interaction partners

  1. OAT1 (show KCNK3 Proteins) and NaDC3 (show SLC13A3 Proteins) in the basolateral membrane and OAT4 (show SLC22A9 Proteins) in the luminal membrane of proximal tubule cells are responsible for the avid renal secretion of N-carbamoylglutamate.

  2. BCL6 (show BCL6 Proteins) constitutes a promising candidate gene for the regulation of human OAT1 (show KCNK3 Proteins) transcription

  3. Clopidogrel/clopidogrel carboxylate are weak inhibitors of OAT1 (show KCNK3 Proteins).

  4. The results confirmed that OAT1, OAT3, OCT2, MATE1, and MATE2-K were coexpressed in tubular epithelial cells.

  5. transport of xanthurenic acid by OAT1 (show KCNK3 Proteins) and OAT3 (show SLC22A8 Proteins)

  6. PKC (show PRRT2 Proteins) isoform PKCalpha (show PKCa Proteins) was responsible for OAT1 (show KCNK3 Proteins) ubiquitination.

  7. It was shown that human OAT3 (show SLC22A8 Proteins) and OAT1 (show KCNK3 Proteins) cannot be involved in the renal extraction of glutathione from blood, but OAT1 (show KCNK3 Proteins) could support intracellular glutathione synthesis by taking up cysteinyl glycine.

  8. Both hOAT1 and hOAT3 (show SLC22A8 Proteins) markedly stimulated the uptake of kynurenic acid into oocytes.

  9. High urine OAT1 (show KCNK3 Proteins) and OAT3 (show SLC22A8 Proteins) and low OAT4 (show SLC22A9 Proteins) is associated with early reversible proximal tubular damage.

  10. The data reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3 (show SLC13A3 Proteins), OAT1 (show KCNK3 Proteins), and OAT3 (show SLC22A8 Proteins)

Mouse (Murine) Solute Carrier Family 22 Member 6 (SLC22A6) interaction partners

  1. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3 (show SLC22A8 Proteins)).

  2. OAT1-deficient mice showed abnormal LTP (show SCP2 Proteins) and higher spine numbers but with a much lesser maturity extent.

  3. At the protein level, mOat3 (show SLC22A8 Proteins) and mOat1 exhibit sex-dependent expression with an opposite pattern; mOat3 (show SLC22A8 Proteins) is female dominant due to androgen inhibition, while mOat1 is male dominant due to androgen stimulation.

  4. Oat1 potentially plays a major role in the rate limiting step in the uptake and excretion of putative toxic metabolites

  5. acute kidney injury by HgCl(2) was found to be mediated mainly by Oat1.

  6. functional differences in the relative importance of OAT1 and OAT3 (show SLC22A8 Proteins) in antiviral handling in developing and mature tissue

  7. the ontogenic pattern of expression of OAT1 and OAT3 (show SLC22A8 Proteins) in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus

  8. Although all cysteine mutants of mOAT1 were sensitive to the inhibition by PCMBS, C49A (show IL24 Proteins) was less sensitive than the wild-type mOAT1, suggesting that the modification of Cys49 may play a role in the inhibition of mOAT1 by PCMBS.

  9. analysis of physiological substrates of OAT1

  10. the substrate binding preferences and transport function of olfactory organic anion transporter, Oat6 (show SLC22A20 Proteins), in comparison with the more broadly expressed transporter, Oat1

Solute Carrier Family 22 Member 6 (SLC22A6) Protein Profile

Protein Summary

The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene.

Gene names and symbols associated with SLC22A6

  • solute carrier family 22 (organic anion transporter), member 6 (SLC22A6)
  • Solute carrier family 22 member 6 (s22a6)
  • organic anion transporter (oat)
  • organic anion transporter-like (POAT1-1)
  • renal organic anion transporter 1 (rbOAT1) (ROAT1)
  • solute carrier family 22 (organic anion transporter), member 6 (Slc22a6)
  • solute carrier family 22 (organic anion transporter), member 6 (slc22a6)
  • HOAT1 protein
  • mOat1 protein
  • nkt protein
  • oat1 protein
  • oat1-B protein
  • Orctl1 protein
  • paht protein
  • roat1 protein
  • Slc22a6 protein
  • slc22a6-B protein
  • zgc:77073 protein

Protein level used designations for SLC22A6

solute carrier family 22 (organic anion transporter), member 6 , solute carrier family 22 member 6 , ROAT1 , Solute carrier family 22 member 6 , organic anion transporter 1 , renal organic anion transporter 1 , zfOat , pOAT1 , putative organic anion transporter , rbROAT1 , PAH transporter , hPAHT , hROAT1 , para-aminohippurate transporter , kidney-specific transport protein , mNKT , mROAT1 , novel kidney transcript , organic cationic transporter-like 1 , rROAT1 , solute carrier family 22, member 6 , ROAT1-B , organic cation transporter 1-B , renal organic anion transporter 1-B , solute carrier family 22 member 6-B

GENE ID SPECIES
451273 Pan troglodytes
100172181 Pongo abelii
100195115 Salmo salar
404609 Danio rerio
397223 Sus scrofa
100008851 Oryctolagus cuniculus
9356 Homo sapiens
18399 Mus musculus
29509 Rattus norvegicus
447487 Xenopus laevis
476050 Canis lupus familiaris
407180 Bos taurus
100444271 Pongo abelii
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