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Solute Carrier Family 23 (Nucleobase Transporters), Member 2 Proteins (SLC23A2)

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. Additionally we are shipping SLC23A2 Antibodies (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC23A2 9962 Q9UGH3
Rat SLC23A2 SLC23A2 50622 Q9WTW8
SLC23A2 54338 Q9EPR4
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Top SLC23A2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SLC23A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Solute Carrier Family 23 (Nucleobase Transporters), Member 2 (SLC23A2) Interaction Partners

Human Solute Carrier Family 23 (Nucleobase Transporters), Member 2 (SLC23A2) interaction partners

  1. Significant methylation changes in the SLC23A2 and NCOR2 regulatory regions.

  2. Vitamin C supplementation significantly increases skeletal muscle SVCT2 protein expression.

  3. ascorbic acid uptake mechanism, kinetics, and regulation by sodium dependent vitamin C transporter (SVCT2) in MDA-MB231, T47D and ZR-75-1 cells.

  4. Together, these data clarify previous inconsistencies in the literature andimplicate SVCT2 as the pericyte ascorbate transporter.

  5. The functional expression of SVCT2 was detected in HEK293 cells.The kinetic analysis suggested that an ascorbate-dependent mechanism accounts for targeted SVCT2 expression in the developing kidney during medullary epithelial cell differentiation.

  6. We propose that the mitochondrial localization of SVCT2 is a property shared across cells, tissues, and species.

  7. Demonstrate that the expression of SVCT2 transporter is significantly down-regulated in human grade 3 osteoarthritic tissues.

  8. polymorphisms in SLC23A1/2 genes influenced ascorbate concentration in aqueous humor and lens nucleus.

  9. Genetic variation in the sodium-dependent vitamin C transporter 2 may have a role in acute coronary syndrome in women

  10. Data show that the mRNA level of svct2 was approximately 600- to 900-fold higher than that of svct1 (show SVCT1 Proteins) indicating SVCT2 is a main isoform in fibroblast OUMS-36 cells, and no significant difference in svct2 mRNA and protein between young and old cells.

Rabbit Solute Carrier Family 23 (Nucleobase Transporters), Member 2 (SLC23A2) interaction partners

  1. Our studies demonstrate that the active SVCT2 is expressed in IVD (show IVD Proteins) cells and that the expression of this transporter is regulated by growth factors IGF-1 (show IGF1 Proteins) and dexamethasone

Mouse (Murine) Solute Carrier Family 23 (Nucleobase Transporters), Member 2 (SLC23A2) interaction partners

  1. Study shows that SVCT2 is regulated at the post-transcriptional level by miR (show MLXIP Proteins)-141 and miR (show MLXIP Proteins)-200a during osteogenic differentiation of bone marrow stromal cells.

  2. Results indicate that both the SVCT2 transporter and oxidative stress play a vital role in BMSC attachment, migration and cytoskeletal re-arrangement.

  3. The functional expression of SVCT2 was detected in HEK293 cells.The kinetic analysis suggested that an ascorbate-dependent mechanism accounts for targeted SVCT2 expression in the developing kidney during medullary epithelial cell differentiation.

  4. Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against oxidative stress.

  5. the expression and transport activity of SVCT2 in brain capillary endothelial cells after transient ischemia

  6. Expression of various collagen types is reduced in sciatic nerves of SVCT2(+/-) heterozygous mice compared to wild-type.

  7. The results suggest that expression of the SVCT2 is differentially regulated during embryonic development and in adulthood.

  8. Evidence of increased apoptosis in SVCT2(-/-) mice and disruption of the basement membrane in fetal brain.

  9. By using primary cultured hepatocytes from SMP30/GNL (show RGN Proteins) KO mice, we found that SVCT1 (show SVCT1 Proteins) and SVCT2 mRNA expression levels and AA uptake ability were significantly enhanced in the hepatocytes of ascorbic acid-depleted SMP30/GNL (show RGN Proteins) KO mice.

  10. These results provide evidence for the first time that uptake of ascorbic acid in the peripheral nervous system is crucially dependent on the expression and activity of SVCT2.

SLC23A2 Protein Profile

Protein Summary

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.

Gene names and symbols associated with SLC23A2

  • solute carrier family 23 (ascorbic acid transporter), member 2 (SLC23A2)
  • solute carrier family 23 (ascorbic acid transporter), member 2 (Slc23a2)
  • solute carrier family 23 (nucleobase transporters), member 2 (SLC23A2)
  • solute carrier family 23 (nucleobase transporters), member 2 (Slc23a2)
  • AI844736 protein
  • mKIAA0238 protein
  • NBTL1 protein
  • Slc23a1 protein
  • SLC23A2 protein
  • SVCT2 protein
  • YSPL2 protein
  • YSPL3 protein

Protein level used designations for SLC23A2

Na(+)/L-ascorbic acid transporter 2 , hSVCT2 , nucleobase transporter-like 1 protein , sodium-dependent vitamin C transporter-2 , solute carrier family 23 (nucleobase transporters), member 1 , solute carrier family 23 (nucleobase transporters), member 2 , solute carrier family 23 member 2 , yolk sac permease-like molecule 2 , sodium-coupled ascorbic acid transporter 2 , sodium-dependent vitamin C transporter 2 , sodium-coupled ascorbic acid transporter SVCT2 , SVCT-2 , mSVCT2

GENE ID SPECIES
9962 Homo sapiens
50622 Rattus norvegicus
419520 Gallus gallus
403490 Canis lupus familiaris
397367 Sus scrofa
783536 Bos taurus
100009466 Oryctolagus cuniculus
54338 Mus musculus
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