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Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 Proteins (Slc25a12)

Slc25a12 encodes a calcium-binding mitochondrial carrier protein. Additionally we are shipping Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 Antibodies (49) and Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Slc25a12 8604 O75746
Rat Slc25a12 Slc25a12 362145  
Slc25a12 78830 Q8BH59
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Top Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

Slc25a12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) Interaction Partners

Human Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) interaction partners

  1. rs2056202 and rs2292813 in SLC25A12 may contribute significantly to autism spectrum disorders risk.

  2. Compares and contrasts all the known human SLC25A (show SLC25A25 Proteins)* genes and includes functional information.

  3. The physiological roles of AGC1 (show ACAN Proteins), its links to calcium homeostasis, and its involvement in autism pathogenesis, are reviewed.

  4. Variants of the AGC1 (show ACAN Proteins)-encoding SLC25A12 gene were neither correlated with AGC (show ACAN Proteins) activation nor associated with autism-spectrum disorders in 309 simplex and 17 multiplex families.

  5. SLC25A12 gene is linked to autism

  6. Aralar1 has a role in determining glucose metabolic fate, mitochondrial activity, and insulin (show INS Proteins) secretion in beta cells

  7. These results suggest that SLC25A12 is not a major contributor to autism risk in these families.

  8. it is unlikely that the SLC25A12 polymorphisms investigated play a substantial role in conferring susceptibility to schizophrenia

  9. rs2056202 polymorphism in SLC25A12 may be associated with levels of routines and rituals in autism and related disorders

  10. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects.

Mouse (Murine) Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) interaction partners

  1. Muller glia compensate for their unique metabolic adaptations by using lactate and aspartate from neurons as surrogates for their missing PK and AGC1 (show ACAN Proteins).

  2. Aralar (show slc25a13 Proteins) protein & mRNA expressions were the same in adult neurons & astrocytes, whole brain,& well-differentiated astrocyte cultures, but not until late development, like the late-maturing brain ability to form & degrade glutamate (show GRIN1 Proteins).

  3. Aralar (show slc25a13 Proteins)-knockout postnatal mice show hyperactivity, anxiety-like behavior, and hyperreactivity with a decrease of dopamine (DA) in terminal-rich regions.

  4. Postnatal Electrophysiological Development Is Arrested in Aralar (show slc25a13 Proteins)-Knockout Mice.

  5. Aralar1 was clearly separated, unambiguously identified and characterized from protein extracts of mouse hippocampus by the use of the multidimensional gel electrophoretic steps.

  6. Slc25a12-knockout mice, which showed no AGC1 (show ACAN Proteins) by immunoblotting but displayed delayed development and died around 3 weeks after birth. In postnatal day 13 to 14 knockout brains, the brains were smaller with no obvious alteration in gross structure.

  7. Expression of the aspartate/glutamate (show GRIN1 Proteins) mitochondrial carriers aralar1 and citrin (show slc25a13 Proteins) during development

  8. These results show that aralar (show slc25a13 Proteins) plays an important role in myelin formation by providing aspartate for the synthesis of N-acetylaspartate in neuronal cells.

  9. aralar (show slc25a13 Proteins) has an essential role in the transduction of small Ca2 (show CA2 Proteins)+ signals to neuronal mitochondria

  10. Aralar (show slc25a13 Proteins) and citrin (show slc25a13 Proteins), when expressed as single isoforms in heart, confer differences in Ca(2 (show CA2 Proteins)+) activation of shuttle activity, probably associated with their structural differences.

Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) Protein Profile

Protein Summary

This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with Slc25a12

  • solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (slc25a12)
  • solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (SLC25A12)
  • solute carrier family 25 (aspartate/glutamate carrier), member 12 (slc25a12)
  • solute carrier family 25 (aspartate/glutamate carrier), member 12 (SLC25A12)
  • solute carrier family 25 (aspartate/glutamate carrier), member 12 (Slc25a12)
  • solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (Slc25a12)
  • 2610002D09Rik protein
  • AGC1 protein
  • AI839531 protein
  • ARALAR protein
  • ARALAR1 protein
  • B230107K20Rik protein
  • BB129864 protein
  • cb929 protein
  • cb1094 protein
  • RGD1561141 protein
  • wu:fj94c07 protein
  • zgc:66248 protein

Protein level used designations for Slc25a12

calcium-binding mitochondrial carrier protein Aralar1 , solute carrier family 25 (mitochondrial carrier, Aralar), member 12 , mitochondrial solute carrier family 25 member 12 , araceli hiperlarga , calcium binding mitochondrial carrier superfamily member Aralar1 , mitochondrial aspartate glutamate carrier 1 , solute carrier family 25, member 12 , solute carrier family 25 member 12

GENE ID SPECIES
337675 Danio rerio
431387 Gallus gallus
459736 Pan troglodytes
695173 Macaca mulatta
100598367 Nomascus leucogenys
443574 Xenopus laevis
8604 Homo sapiens
478798 Canis lupus familiaris
362145 Rattus norvegicus
100172446 Pongo abelii
539494 Bos taurus
78830 Mus musculus
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