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Solute Carrier Family 26, Member 4 Proteins (SLC26A4)

Mutations in SLC26A4 are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. Additionally we are shipping Solute Carrier Family 26, Member 4 Antibodies (24) and Solute Carrier Family 26, Member 4 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SLC26A4 SLC26A4 29440 Q9R154
SLC26A4 5172 O43511
SLC26A4 23985 Q9R155
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Top Solute Carrier Family 26, Member 4 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SLC26A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
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More Proteins for Solute Carrier Family 26, Member 4 (SLC26A4) Interaction Partners

Human Solute Carrier Family 26, Member 4 (SLC26A4) interaction partners

  1. Mutations in RAI1 (show DOM3Z Proteins), OTOF, and SLC26A4 may have roles in nonsyndromic hearing loss in Altaian families in Siberia

  2. A homozygous c.-2071_307+3801del7666 deletion of SLC26A4 was identified in patient D1467-1. This novel genomic deletion was subsequently identified in 18% (4/22) of the Chinese Han EVA probands.

  3. GJB2 (show GJB2 Proteins) and SLC26A4 mutations are associated with good post-implant outcomes.

  4. exon sequencing of GJB2 (show GJB2 Proteins), SLC26A4, and mtDNA12SrRNA reveals that non-syndromic deafness in Xiamen, China appears to have a genetic etiology

  5. Anoctamin and pendrin are two plausible candidates as mediators of apical iodide efflux--{review}

  6. Data suggest that ombined hearing screening and genetic screening of gap junction protein beta 2 (GJB2 (show GJB2 Proteins)), mtDNA 12srRNA and solute carrier (show SERTAD2 Proteins) family 26, member 4 protein SLC26A4 mutations can improve the rate of detection.

  7. Increased expression of the epithelial anion transporter pendrin/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis

  8. codon 723 was a hot-spot region in SLC26A4 with a significant impact on the structure and function of pendrin, and acted as one of the genetic factors responsible for the development of hearing loss.

  9. The prevalence of SLC26A4 mutations was 12.39%, 8.84%, and 8.57% in Han Chinese, Hui people, and Tibetan participants, respectively. The c.919-2 A>G mutation was the most common form, accounting for 60.47% of all SLC26A4 mutant alleles.

  10. Presence of mono-allelic mutations of SLC26A4 in non-syndromic enlarged vestibular aqueduct patients is etiologically associated with this disorder.

Mouse (Murine) Solute Carrier Family 26, Member 4 (SLC26A4) interaction partners

  1. The strial dysfunction and degeneration are the primary causes of irreversible progressive hearing loss in our Slc26a4-insufficient mouse model of vestibular aqueduct syndrome.

  2. The Role of Epithelial Sodium Channel ENaC (show SCNN1A Proteins) and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC (show SLC12A3 Proteins)) Inactivation.

  3. Pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release.

  4. Pendrin gene ablation reduced ENaC (show SCNN1A Proteins)-mediated Na(+) absorption by reducing channel open probability as well as by reducing channel density through changes in subunit total protein abundance and subcellular distribution.

  5. The result provides insight into the role of Na+ transport in the development and regulation of endolymphatic hydrops due to pendrin mutations.

  6. Insufficient availability of thyroid hormone (show PTH Proteins) during inner ear development plays an important role in the mechanism underlying deafness as a result of SLC26A4 mutations.

  7. Together these data suggest that pertussis toxin contributes to pertussis pathology through the upregulation of pendrin, which promotes conditions favoring inflammatory pathology.

  8. Using a transgenic mouse line in which all Slc26a4 expression was under the control of doxycycline, showed that fluctuations of hearing result from fluctuations of endocochlear potential and stria vascularis dysfunction in Slc26a4-insufficient mouse ears

  9. Pendrin is expressed in platelets and is presumably regulated by SGK1 (show SGK1 Proteins) and mineralocorticoids.

  10. This review summarizes recent studies in mouse models that have been developed to delineate the role of pendrin in the physiology of hearing

Solute Carrier Family 26, Member 4 (SLC26A4) Protein Profile

Protein Summary

Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene\; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters.

Gene names and symbols associated with SLC26A4

  • solute carrier family 26, member 4 (SLC26A4)
  • solute carrier family 26 (anion exchanger), member 4 (Slc26a4)
  • solute carrier family 26 (anion exchanger), member 4 (SLC26A4)
  • solute carrier family 26, member 4 (Slc26a4)
  • DFNB4 protein
  • EVA protein
  • PDS protein
  • pendrin protein
  • TDH2B protein

Protein level used designations for SLC26A4

Pendred syndrome homolog , pendrin , sodium-independent chloride/iodide transporter , solute carrier family 26, member 4 , Pendred's syndrome

GENE ID SPECIES
100060222 Equus caballus
29440 Rattus norvegicus
5172 Homo sapiens
23985 Mus musculus
483263 Canis lupus familiaris
100622822 Sus scrofa
530241 Bos taurus
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