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SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein. Additionally we are shipping SLC3A2 Antibodies (336) and SLC3A2 Kits (12) and many more products for this protein.
Showing 10 out of 28 products:
These results demonstrate a novel fundamental role of LAT1 to support the protein expression of 4F2hc via a chaperone-like function in chorionic trophoblasts.
CD98 is required for endothelial cell growth. CD98-specific reagents could have a dual anticancer effect: directly by inhibiting tumor cell proliferation and indirectly by preventing tumor angiogenesis
Taken together, our data indicate that T cell-specific deletion of CD98hc can contribute to the prevention of GvHD development due to the attenuation of lymphocyte migration and by increasing the generation of Treg cells.
data establish CD98hc as a master protective gene at the cross-road of redox control and AA availability, making it a relevant therapeutic target in cancer.
ubiquitylation and the resulting downregulation of CD98 can limit cell proliferation and clonal expansion.
CD98hc mediated this stiffness sensing by increasing Rho kinase (show ROCK2 Proteins) (ROCK) activity.
Mice lacking CD98hc in B cells are protected from experimental autoimmune encephalomyelitis.
CD98 heavy chain is crucial for T cell-mediated autoimmune colitis. CD98 heavy chain deficiency in T cells is involved in increasing induced regulatory T cells.
The role of SLC3A2 in keratinocytes is not in cell adhesion but, instead, in cell proliferation and migration through modulating integrin signaling by the Src (show SRC Proteins)-RhoA (show RHOA Proteins) pathway.
CD98-dependent amino acid transport increased renal tubular epithelial cell proliferation is mediated by Erk (show EPHB2 Proteins) and p38 MAPK (show MAPK14 Proteins) signaling.
These results demonstrate a novel fundamental role of LAT1 (show LAT Proteins) to support the protein expression of 4F2hc via a chaperone-like function in chorionic trophoblasts.
SLC3A2 is upregulated in osteosarcoma and plays a crucial role in tumor growth.
Expression levels of CD98 and beta1-integrin-A (the activated form of beta1-integrin) were significantly increased in hepatocellular carcinoma (HCC (show FAM126A Proteins)) tissues relative to those of normal liver tissues.
Data suggest that increased CD98 (4F2hc) expression plays an essential role in tumor aggressiveness and metastasis.
Study demonstrated that the mRNA expression levels of the two system xc- subunits, SLC7A11 and SLC3A2, in peripheral white blood cells are lowered in patients with schizophrenia than healthy individuals
exposure to diesel exhaust particle extract induces functional overexpression of the amino acid transporter (show SLC43A2 Proteins) LAT1 (show LAT Proteins)/CD98hc in lung cells
The detergent-induced stabilization of the purified human 4F2hc-LAT2 (show LAT2 Proteins) complex presented here paves the way towards its crystallization and structure determination at high-resolution
HSV-1 recruited cellular fusion regulatory proteins CD98hc and beta1 integrin to the nuclear membrane for viral de-envelopment fusion.
CD98-mediated phosphorylation of focal adhesion kinase may facilitate the assembly of pro-tumorigenic signaling complexes and the subsequent amplification of a positive feedback loop of CD98/integrins/FAK (show PTK2 Proteins)/RhoA (show RHOA Proteins)/ROCK.
This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
, solute carrier family 3, member 2
, 4F2 cell-surface antigen heavy chain
, CD98 antigen
, CD98 heavy chain
, antigen identified by monoclonal antibodies 4F2
, type II transmembrane protein
, blood-brain barrier large neutral amino acid transporter heavy chain 4F2
, antigen defined by monoclonal antibody 4F2, heavy chain
, antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43
, lymphocyte activation antigen 4F2 large subunit
, monoclonal antibody 44D7