Solute Carrier Family 30, Member 10 Proteins (SLC30A10)

SLC30A10 is highly expressed in the liver and is inducible by manganese. Additionally we are shipping SLC30A10 Antibodies (22) and SLC30A10 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC30A10 55532 Q6XR72
Mouse SLC30A10 SLC30A10 226781 Q3UVU3
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Top SLC30A10 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
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SLC30A10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Solute Carrier Family 30, Member 10 (SLC30A10) Interaction Partners

Human Solute Carrier Family 30, Member 10 (SLC30A10) interaction partners

  1. SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK (show EIF2AK3 Proteins)-ATF4 (show ATF4 Proteins) pathway.

  2. xpressing either wild-type or mutant forms of SLC30A10 was sufficient to inhibit the effect of ATP2C1 (show ATP2C1 Proteins) in response to Mn challenge in both zebrafish embryos and HeLa cells. These findings suggest that either activating ATP2C1 (show ATP2C1 Proteins) or restoring the Mn-induced trafficking of ATP2C1 (show ATP2C1 Proteins) can reduce Mn accumulation, providing a possible target for treating HMDPC.

  3. results indicate that residues in the transmembrane and C-terminal domains together confer optimal manganese transport capability to SLC30A10 and suggest that the mechanism of ion coordination in the transmembrane domain of SLC30A10 may be substantially different from that in YiiP/other SLC30 proteins.

  4. allele was also associated with increased sway velocity (15%, P = .033; adjusted for age and sex) and reduced SLC30A10 expression

  5. We describe early disease manifestations (including videos) in 5 previously unreported Indian children, carrying novel homozygous SLC30A10 mutation

  6. SLC30A10 is a cell surface-localized manganese efflux transporter that reduces manganese levels and protects against manganese toxicity.

  7. These results suggest that both the up-regulation of ZIP14 (show SLC39A14 Proteins) and the down-regulation of ZnT10 by IL-6 (show IL6 Proteins) might have enhanced the accumulation of manganese in SH-SY5Y cells.

  8. a case of inherited manganism caused by SLC30A10 mutation is presented

  9. ZnT10 is significantly decreased in the frontal cortex in Alzheimer's disease.

  10. This review will address Mn transport proteins, the newly discovered SLC30A10 mutations and their implications to Parkinsonism and Mn regulation.

Zebrafish Solute Carrier Family 30, Member 10 (SLC30A10) interaction partners

  1. xpressing either wild-type or mutant forms of SLC30A10 was sufficient to inhibit the effect of ATP2C1 (show ATP2C1 Proteins) in response to Mn challenge in both zebrafish embryos and HeLa cells. These findings suggest that either activating ATP2C1 (show ATP2C1 Proteins) or restoring the Mn-induced trafficking of ATP2C1 (show ATP2C1 Proteins) can reduce Mn accumulation, providing a possible target for treating HMDPC.

Mouse (Murine) Solute Carrier Family 30, Member 10 (SLC30A10) interaction partners

  1. SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK (show EIF2AK3 Proteins)-ATF4 (show ATF4 Proteins) pathway.

  2. discovery highlights the importance of determining the role of thyroid dysfunction in the onset and progression of manganese-induced disease and identifies Slc30a10 knock-out mice as a new model for studying thyroid biology.

SLC30A10 Protein Profile

Protein Summary

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with SLC30A10

  • solute carrier family 30, member 10 (SLC30A10)
  • solute carrier family 30 (zinc transporter), member 10 (slc30a10)
  • solute carrier family 30, member 10 (Slc30a10)
  • E130106K10Rik protein
  • Gm212 protein
  • HMDPC protein
  • ZnT-10 protein
  • ZNT8 protein
  • ZNT10 protein
  • ZRC1 protein

Protein level used designations for SLC30A10

zinc transporter 10 , zinc transporter 8 , solute carrier family 30, member 10 , solute carrier family 30 (zinc transporter), member 10 , ZnT10 , znT-10

GENE ID SPECIES
55532 Homo sapiens
469681 Pan troglodytes
555724 Danio rerio
226781 Mus musculus
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