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Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) ELISA Kits

The protein encoded by SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. Additionally we are shipping Solute Carrier Family 30 (Zinc Transporter), Member 8 Antibodies (43) and Solute Carrier Family 30 (Zinc Transporter), Member 8 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SLC30A8 239436 Q8BGG0
SLC30A8 299903 P0CE46
SLC30A8 169026 Q8IWU4
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Top Solute Carrier Family 30 (Zinc Transporter), Member 8 ELISA Kits at antibodies-online.com

Showing 3 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.057 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$736.84
Details
Rat
  96 Tests Log in to see 11 to 13 Days
$875.60
Details
Mouse
  96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for Solute Carrier Family 30 (Zinc Transporter), Member 8 Interaction Partners

Pig (Porcine) Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. The absence of ZnT8 in glucagon (show GCG ELISA Kits)-producing cells in pig islets indicates that zinc homeostasis is mediated by a different cellular mechanism compared with human islet cells.

Mouse (Murine) Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. Deletion of ZnT8 in a limited subset ( approximately 15%) of alpha-pancreatic cells is sufficient to increase glucagon (show GCG ELISA Kits) secretion at low glucose concentrations in vitro and in vivo and to improve the response to hypoglycemia.

  2. ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 (show RBMS1 ELISA Kits) plays a neuroprotective role against ischemic insult

  3. Data suggest that, despite a marked reduction in islet zinc content, the absence of ZnT-8 does not have a substantial impact on mouse physiology.

  4. Beta-cell Znt8 alone does not considerably aggravate weight gain and glucose intolerance during metabolic stress imposed by an high-fat high-calorie diet. Global loss of Znt8 is involved in diet-induced obesity and resulting insulin (show INS ELISA Kits) resistance.

  5. Downregulation of ZnT8 may be associated with impaired function of beta-cells in diabetes.

  6. Mutation of two Pdx-1 (show PDX1 ELISA Kits)-binding sites in enhancer A markedly reduces fusion gene expression suggesting that this factor contributes to Slc30a8 expression in beta-c

  7. Our data indicate that while, under the conditions studied, ZnT8 is absolutely essential for proper beta cell function, it is largely dispensable for alpha cell function.

  8. Results suggest that an acute decrease in ZnT8 levels impairs beta-cell function and Zn homeostasis, and may contribute to inflammatory cytokine-induced alterations in beta-cell function.

  9. Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands.

  10. Slc30a8 gene deletion is accompanied by a modest impairment in insulin (show INS ELISA Kits) secretion without major alterations in glucose metabolism.

Human Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. Studies indicate that people who have particular mutations in a gene called SLC30A8 (Solute carrier family 30, member 8) are 65% less likely to get diabetes.

  2. Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk

  3. Size and the direction of the effect of SLC30A8 risk alleles in man.

  4. We describe early disease manifestations (including videos) in 5 previously unreported Indian children, carrying novel homozygous SLC30A10 mutation

  5. Zinc supplementation appears to affect the early insulin (show INS ELISA Kits) response to glucose differentially by rs13266634 genotype and could be beneficial for diabetes prevention and/or treatment for some individuals based on SLC30A8 variation.

  6. Data indicate that the SLC30A8 polymorphisms are associated with type 2 diabetes in the Saudi population but not for FTO (show FTO ELISA Kits), MC4R (show MC4R ELISA Kits) and KCNQ1 (show KCNQ1 ELISA Kits) gene variants.

  7. genotypes of the polymorphic markers of KCNJ11 (show KCNJ11 ELISA Kits), SLC30A8 and CDKN2B (show CDKN2B ELISA Kits) genes showed the presence of association with T2DM in Russian population, while for the FTO (show FTO ELISA Kits) gene was not found statistically significant associations with type 2 diabetes

  8. Suggest rs3019885 SLC30A8 SNP is not a susceptibility factor for abdominal aortic aneurysms in an Italian population.

  9. SLC30A10 is a cell surface-localized manganese efflux transporter that reduces manganese levels and protects against manganese toxicity.

  10. zinc transporter 8 and MAP3865c homologous epitopes are recognized by Hashimoto's thyroiditis subjects from Sardinia

Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) Antigen Profile

Antigen Summary

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with SLC30A8

  • solute carrier family 30 (zinc transporter), member 8 (slc30a8) antibody
  • solute carrier family 30 (zinc transporter), member 8 (SLC30A8) antibody
  • solute carrier family 30 member 8 (LOC100347644) antibody
  • solute carrier family 39 (zinc transporter), member 8 (SLC39A8) antibody
  • solute carrier family 30 (zinc transporter), member 8 (Slc30a8) antibody
  • solute carrier family 30, member 10 (SLC30A10) antibody
  • C820002P14Rik antibody
  • DKFZp469F0128 antibody
  • HMDPC antibody
  • slc30a3 antibody
  • wu:fe49g03 antibody
  • ZnT-8 antibody
  • ZnT-10 antibody
  • ZNT8 antibody
  • ZNT10 antibody
  • ZRC1 antibody

Protein level used designations for SLC30A8

ZnT8 , solute carrier family 30 (zinc transporter), member 8 , zinc transporter 8 , znT-8 , solute carrier family 30 member 8 , solute carrier family 30 (zinc transporter), member 3 , zinc transporter 8-like , solute carrier family 39 (zinc transporter), member 8 , zinc transporter ZIP8 , zinc transporter ZnT-8 , zinc transporter 10

GENE ID SPECIES
326926 Danio rerio
420285 Gallus gallus
464348 Pan troglodytes
482022 Canis lupus familiaris
496450 Xenopus (Silurana) tropicalis
701127 Macaca mulatta
100056898 Equus caballus
100155672 Sus scrofa
100461137 Pongo abelii
100595779 Nomascus leucogenys
100347644 Oryctolagus cuniculus
430411 Gallus gallus
461405 Pan troglodytes
478494 Canis lupus familiaris
508193 Bos taurus
100171966 Pongo abelii
100385303 Callithrix jacchus
239436 Mus musculus
299903 Rattus norvegicus
169026 Homo sapiens
496294 Xenopus laevis
55532 Homo sapiens
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