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Solute Carrier Family 30 (Zinc Transporter), Member 8 Proteins (SLC30A8)

SLC30A8 is highly expressed in the liver and is inducible by manganese. Additionally we are shipping Solute Carrier Family 30 (Zinc Transporter), Member 8 Antibodies (43) and Solute Carrier Family 30 (Zinc Transporter), Member 8 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse SLC30A8 SLC30A8 239436 Q8BGG0
Rat SLC30A8 SLC30A8 299903 P0CE46
SLC30A8 169026 Q8IWU4
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Top Solute Carrier Family 30 (Zinc Transporter), Member 8 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$492.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$684.50
Details

SLC30A8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) Interaction Partners

Pig (Porcine) Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. slc30A8 colocalizes with ghrelin (show GHRL Proteins) and motilin (show MLN Proteins) in the gastrointestinal tract of pigs

  2. The absence of ZnT8 in glucagon (show GCG Proteins)-producing cells in pig islets indicates that zinc homeostasis is mediated by a different cellular mechanism compared with human islet cells.

Mouse (Murine) Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. Our findings demonstrate that glucose homeostasis in the mouse improves as beta-cell ZnT8 activity increases, and remarkably, these changes track Zn(2+) rather than insulin (show INS Proteins) release in vitro.

  2. Deletion of ZnT8 in a limited subset ( approximately 15%) of alpha-pancreatic cells is sufficient to increase glucagon (show GCG Proteins) secretion at low glucose concentrations in vitro and in vivo and to improve the response to hypoglycemia.

  3. ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 (show RBMS1 Proteins) plays a neuroprotective role against ischemic insult

  4. Data suggest that, despite a marked reduction in islet zinc content, the absence of ZnT-8 does not have a substantial impact on mouse physiology.

  5. Beta-cell Znt8 alone does not considerably aggravate weight gain and glucose intolerance during metabolic stress imposed by an high-fat high-calorie diet. Global loss of Znt8 is involved in diet-induced obesity and resulting insulin (show INS Proteins) resistance.

  6. Downregulation of ZnT8 may be associated with impaired function of beta-cells in diabetes.

  7. Mutation of two Pdx-1 (show PDX1 Proteins)-binding sites in enhancer A markedly reduces fusion gene expression suggesting that this factor contributes to Slc30a8 expression in beta-c

  8. Our data indicate that while, under the conditions studied, ZnT8 is absolutely essential for proper beta cell function, it is largely dispensable for alpha cell function.

  9. Results suggest that an acute decrease in ZnT8 levels impairs beta-cell function and Zn homeostasis, and may contribute to inflammatory cytokine-induced alterations in beta-cell function.

  10. Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands.

Human Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) interaction partners

  1. Detection of ZnT8 antibodies in blood precedes detection of classical islet antibodies in children at risk of developing diabetes mellitus type 1.

  2. Studies indicate that people who have particular mutations in a gene called SLC30A8 (Solute carrier (show SERTAD2 Proteins) family 30, member 8) are 65% less likely to get diabetes.

  3. Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk

  4. Size and the direction of the effect of SLC30A8 risk alleles in man.

  5. We describe early disease manifestations (including videos) in 5 previously unreported Indian children, carrying novel homozygous SLC30A10 mutation

  6. Zinc supplementation appears to affect the early insulin (show INS Proteins) response to glucose differentially by rs13266634 genotype and could be beneficial for diabetes prevention and/or treatment for some individuals based on SLC30A8 variation.

  7. Data indicate that the SLC30A8 polymorphisms are associated with type 2 diabetes in the Saudi population but not for FTO (show FTO Proteins), MC4R (show MC4R Proteins) and KCNQ1 (show KCNQ1 Proteins) gene variants.

  8. genotypes of the polymorphic markers of KCNJ11 (show KCNJ11 Proteins), SLC30A8 and CDKN2B (show CDKN2B Proteins) genes showed the presence of association with T2DM in Russian population, while for the FTO (show FTO Proteins) gene was not found statistically significant associations with type 2 diabetes

  9. Suggest rs3019885 SLC30A8 SNP is not a susceptibility factor for abdominal aortic aneurysms in an Italian population.

  10. SLC30A10 is a cell surface-localized manganese efflux transporter that reduces manganese levels and protects against manganese toxicity.

Solute Carrier Family 30 (Zinc Transporter), Member 8 (SLC30A8) Protein Profile

Protein Summary

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with SLC30A8

  • solute carrier family 30 (zinc transporter), member 8 (slc30a8)
  • solute carrier family 30 (zinc transporter), member 8 (SLC30A8)
  • solute carrier family 30 member 8 (LOC100347644)
  • solute carrier family 39 (zinc transporter), member 8 (SLC39A8)
  • solute carrier family 30 (zinc transporter), member 8 (Slc30a8)
  • solute carrier family 30, member 10 (SLC30A10)
  • C820002P14Rik protein
  • DKFZp469F0128 protein
  • HMDPC protein
  • slc30a3 protein
  • wu:fe49g03 protein
  • ZnT-8 protein
  • ZnT-10 protein
  • ZNT8 protein
  • ZNT10 protein
  • ZRC1 protein

Protein level used designations for SLC30A8

ZnT8 , solute carrier family 30 (zinc transporter), member 8 , zinc transporter 8 , znT-8 , solute carrier family 30 member 8 , solute carrier family 30 (zinc transporter), member 3 , zinc transporter 8-like , solute carrier family 39 (zinc transporter), member 8 , zinc transporter ZIP8 , zinc transporter ZnT-8 , zinc transporter 10

GENE ID SPECIES
326926 Danio rerio
420285 Gallus gallus
464348 Pan troglodytes
482022 Canis lupus familiaris
496450 Xenopus (Silurana) tropicalis
701127 Macaca mulatta
100056898 Equus caballus
100155672 Sus scrofa
100461137 Pongo abelii
100595779 Nomascus leucogenys
100347644 Oryctolagus cuniculus
430411 Gallus gallus
461405 Pan troglodytes
478494 Canis lupus familiaris
508193 Bos taurus
100171966 Pongo abelii
100385303 Callithrix jacchus
239436 Mus musculus
299903 Rattus norvegicus
169026 Homo sapiens
496294 Xenopus laevis
55532 Homo sapiens
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