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Involved in low-affinity copper uptake (Potential).. Additionally we are shipping and many more products for this protein.
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Human Polyclonal SLC31A2 Primary Antibody for IHC - ABIN965919
Zhou, Gitschier: hCTR1: a human gene for copper uptake identified by complementation in yeast. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 2 references for ABIN965919
The expression of SPL7 and its targets COPT2 and FSD1 (show FSD1 Antibodies) was differently regulated in various light signalling mutants. Under copper deficiency, the expression of both targets decreased drastically in continuous darkness.
Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1 (show SLC31A1 Antibodies), COPT2, COPT6, CSD1, CSD2 (show TGFB1 Antibodies), miRNA398 b/c precursors and FSD1 (show FSD1 Antibodies).
The phenotypes and gene expression changes displayed by a copt2-1 line reveal a role for COPT2 in the cross talk among Cu, Fe, and Pi deficiency responses in Arabidopsis.
Decreased expression of CTR2 is associated with clear cell renal cell carcinoma (show MOK Antibodies).
Studied the interaction of CTR1 (show SLC31A1 Antibodies) and CTR2 in fully malignant HEK293T and OVCAR8 human ovarian cancer cells using a CRISPR-Cas9 knock out system.
Data suggest that SLC31A1 (show SLC31A1 Antibodies) and SLC31A2, despite being structurally closely related and sharing important amino acid motifs, play different roles in copper homeostasis and in platinum-based chemotherapy of neoplasms. [REVIEW]
Over-expression of CTR2 increased exchangeable (show SLC31A1 Antibodies) Cu(+) by 150% and rendered the human epithelial 2008 cancer cell model 2.5-fold resistant to cisplatin.
Increased CTR2 expression is associated with platinum resistance in epithelial ovarian cancer.
hCTR2 is as an oligomeric membrane protein localized in lysosomes, which stimulates copper delivery to the cytosol of human cells at relatively high copper concentrations.
Ctr2 promotes copper uptake at the plasma membrane and plays a role in regulating copper levels in COS-7 cells
CTR2 functions by limiting drug accumulation, and its expression correlates with the sensitivity of human ovarian carcinoma cell lines to cisplatin.
The increase in granular staining and heparin content is compatible with an impact of Ctr2 on mast cell maturation and, in support of this, the absence of Ctr2 resulted in markedly increased mRNA expression, storage, and enzymatic activity of tryptase (show TPSAB1 Antibodies).
In mouse embryo fibroblasts, reduction of CTR1 (show SLC31A1 Antibodies) expression renders cells resistant to cisplatin whereas reduction of CTR2 makes them hypersensitive both in vitro and in vivo.
Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 (show SLC31A1 Antibodies) metal transporter lacking the copper- and cisplatin-binding ecto (show TRIM33 Antibodies)-domain.
Copper transporter 2 regulates the transport of cisplatin through control of the rate of macropinocytosis.
Involved in low-affinity copper uptake (Potential).
solute carrier family 31 (copper transporters), member 2
, probable low affinity copper uptake protein 2
, copper transporter 2
, solute carrier family 31 member 2