anti-Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) Antibodies

The protein encoded by SLC31A1 is a high-affinity copper transporter found in the cell membrane. Additionally we are shipping Solute Carrier Family 31 (Copper Transporters), Member 1 Kits (14) and Solute Carrier Family 31 (Copper Transporters), Member 1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC31A1 1317 O15431
SLC31A1 171135 Q9JK41
SLC31A1 20529 Q8K211
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Top anti-Solute Carrier Family 31 (Copper Transporters), Member 1 Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IHC (p), IHC, WB The photo on the left is antibody staining of hCTR1 overexpressing cell line.  The photo on the right is antibody plus peptide competition staining. Panel 1: human CTR1 staining of breast cancer tissue. Panel 2: human CTR1-antigen competition in breast cancer tissue. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-Slc31a1 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Horse Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Chicken Rabbit Un-conjugated IHC (p) Anti-CTR1 antibody  ABIN960807 IHC staining of human colon, malt. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-CTR1 antibody  ABIN960807 IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Dog Rabbit Un-conjugated IHC (p) Anti-CTR1 antibody  ABIN960806 IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-CTR1 antibody  ABIN960806 IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using SLC31A1 antibody. 100 μL Log in to see 16 Days
$275.00
Details
Human Mouse Un-conjugated IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: SLC31A1/CTR1 Antibody (5E6.1B4) [NBP2-36573] - HepG2 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti SLC31A1/CTR1 (5E6.1B4) NBP2-36573 at a 1:50 dilution overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution. Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective. Immunohistochemistry-Paraffin: SLC31A1/CTR1 Antibody (5E6.1B4) [NBP2-36573] - IHC-P analysis of a formalin fixed and paraffin embedded tissue section of human urinary bladder transitional cell carcinoma (NBP2-30234) using purified CTR1/SLC31A1 antibody clone 5E6.1B4 at 5 ug/ml concentration. 0.1 mg Log in to see 7 to 9 Days
$317.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: SLC31A1/CTR1 Antibody [NBP1-84405] - Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: SLC31A1/CTR1 Antibody [NBP1-84405] - Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli & centrosome. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 12 to 14 Days
$541.80
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 12 to 14 Days
$541.80
Details

SLC31A1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Solute Carrier Family 31 (Copper Transporters), Member 1 Antibodies

  1. Human Polyclonal SLC31A1 Primary Antibody for ICC, IHC (fro) - ABIN151866 : Holzer, Howell: The internalization and degradation of human copper transporter 1 following cisplatin exposure. in Cancer research 2006 (PubMed)
    Show all 12 references for 151866

More Antibodies against Solute Carrier Family 31 (Copper Transporters), Member 1 Interaction Partners

Arabidopsis thaliana Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) interaction partners

  1. Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1, COPT2 (show SLC31A2 Antibodies), COPT6, CSD1, CSD2 (show TGFB1 Antibodies), miRNA398 b/c precursors and FSD1 (show FSD1 Antibodies).

  2. Col (show HDAC1 Antibodies)-0, high-affinity copper transporter COPT1-overexpressing (C1(OE)) seedlings and T-DNA COPT1 insertion mutant (copt1) differ in their copper-transport activity. C1(OE) showed a fivefold higher Cu-induced K(+) efflux at the root tip compared with Col (show HDAC1 Antibodies)-0.

Human Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) interaction partners

  1. we assessed the role of miR (show MLXIP Antibodies)-21 in mediating renal cell carcinoma (show MOK Antibodies) chemoresistance and further showed that miR (show MLXIP Antibodies)-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2 (show SLC22A2 Antibodies), and SLC31A1/CTR1 platinum influx transporter expression

  2. Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2 (show SLC31A2 Antibodies)

  3. It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 and LRRC8A (show LRRC8A Antibodies) protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A (show ATP7A Antibodies), ATP7B (show ATP7B Antibodies)), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes.

  4. CTR1 recycling via clathrin-mediated and Rab11 pathways enable cells to dynamically modulate copper entry

  5. C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1 (show ATOX1 Antibodies)

  6. Studied the interaction of CTR1 and CTR2 (show SLC31A2 Antibodies) in fully malignant HEK293T and OVCAR8 human ovarian cancer cells using a CRISPR-Cas9 knock out system.

  7. High CTR1 Expression is associated with poor response to chemotherapy in Muscle-invasive Bladder Cancer.

  8. Gene silencing of either CTR1 or DMT1 (show DMRT1 Antibodies) did not affect copper accumulation in cells, but deficiency in both CTR1 and DMT1 (show DMRT1 Antibodies) resulted in a complete inhibition of copper uptake.

  9. Two methionine residues in the MXXXM motif of of the CTR1 second transmembrane domain are important for binding to silver.

  10. CTR1, ATP7A (show ATP7A Antibodies), and lysyl oxidase (show LOX Antibodies) were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.

Zebrafish Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) interaction partners

  1. Studies show that zebrafish ctr1 is an essential gene for development.

Mouse (Murine) Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) interaction partners

  1. Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2 (show SLC31A2 Antibodies)

  2. studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) and cisplatin acquisition

  3. CTR1, ATP7A (show ATP7A Antibodies), and lysyl oxidase (show LOX Antibodies) were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.

  4. conclude that Y103 is required for the internalization of hCTR1 in response to Cu, that this occurs by a mechanism other than phosphorylation and that mutation of Y103 modulates the interaction with IRS-4 (show IRS4 Antibodies)

  5. A key regulatory mechanism for mammalian copper transport is through Ctr2 (show SLC31A2 Antibodies)-dependent accumulation of a Ctr1 variant lacking the copper- and cisplatin-binding ecto (show TRIM33 Antibodies)-domain.

  6. conclude that Cu acquired from CTR1 is required for signaling in pathways regulated by RTKs that play major roles in development and cance

  7. There was little difference in rates/kinetics of uptake of copper in the Ctr1+/+ and -/- cells. Endocytosis was not involved.

  8. basal expression of Ctr1 is regulated by HIF2alpha (show EPAS1 Antibodies); however, the induction by hypoxia is a HIF2alpha (show EPAS1 Antibodies)-independent event

  9. Structure-functional organization of eukaryotic high-affinity copper importer CTR1 determines its ability to transport copper, silver and cisplatin

  10. Data show apical localization of Ctr1 in intestinal epithelia and suggest that increased Ctr1 apical localization in response to dietary copper limitation may represent an adaptive response to modulate Ctr1 availability at the site of copper absorption.

Solute Carrier Family 31 (Copper Transporters), Member 1 (SLC31A1) Antigen Profile

Protein Summary

The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper.

Gene names and symbols associated with SLC31A1

  • solute carrier family 31 (copper transporters), member 1 (SLC31A1) antibody
  • copper transporter 1 (LOC100281410) antibody
  • copper transporter 1 (LOC100286321) antibody
  • solute carrier family 31 (copper transporter), member 1 (slc31a1) antibody
  • copper transporter 1 (COPT1) antibody
  • high-affinity copper uptake protein (CTR1) antibody
  • solute carrier family 31 (copper transporter), member 1 (SLC31A1) antibody
  • solute carrier family 31 (copper transporter), member 1 (Slc31a1) antibody
  • solute carrier family 31 (copper transporters), member 1 (slc31a1) antibody
  • solute carrier family 31, member 1 (Slc31a1) antibody
  • 4930445G01Rik antibody
  • AI787263 antibody
  • AU016967 antibody
  • copper transporter 1 antibody
  • COPT1 antibody
  • ctr-1 antibody
  • Ctr1 antibody
  • hctr1 antibody
  • K19M22.24 antibody
  • LRRGT00200 antibody
  • Slc31a1 antibody
  • Xctr1 antibody
  • zgc:76839 antibody

Protein level used designations for SLC31A1

solute carrier family 31 (copper transporters), member 1 , high affinity copper uptake protein 1 , Copper transporter 1 , copper transporter 1 , solute carrier family 31 member 1 , copper transport 1 homolog , Copper uptake transporter 1 , liver regeneration-related protein LRRGT00200 , rCTR1 , high affinity copper uptake protein , solute carrier family 13 (sodium/sulphate symporters), member 1

GENE ID SPECIES
417268 Gallus gallus
464670 Pan troglodytes
481678 Canis lupus familiaris
518976 Bos taurus
706058 Macaca mulatta
100172583 Pongo abelii
100281410 Zea mays
100286321 Zea mays
407919 Xenopus (Silurana) tropicalis
836020 Arabidopsis thaliana
397186 Sus scrofa
1317 Homo sapiens
171135 Rattus norvegicus
403028 Danio rerio
20529 Mus musculus
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