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Solute Carrier Family 34 (Sodium Phosphate), Member 3 Proteins (SLC34A3)

SLC34A3 encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. Additionally we are shipping SLC34A3 Antibodies (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC34A3 142681 Q80SU6
SLC34A3 142680 Q8N130
Rat SLC34A3 SLC34A3 246234 Q8K4R8
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Top SLC34A3 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SLC34A3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
,

More Proteins for Solute Carrier Family 34 (Sodium Phosphate), Member 3 (SLC34A3) Interaction Partners

Mouse (Murine) Solute Carrier Family 34 (Sodium Phosphate), Member 3 (SLC34A3) interaction partners

  1. we have generated a renal-specific and inducible knockout model of NaPi-IIc/Slc34a3. absence of NaPi-IIc does not disturb the homeostasis of Pi in mice. However, ablation of the cotransporter in weaning mice does not alter the homeostasis of Ca2 (show CA2 Proteins)+.

  2. The expression of Npt2c-v1 mRNA was detected in the heart, spleen, testis, uterus, placenta, femur, cerebellum, hippocampus, diencephalon and brain stem and sperm of mouse.

  3. reduced intestinal Pi absorption in VDR (show CYP27B1 Proteins) (-/-) mice does not seem to be the only factor that causes hypophosphatemia; reduced Npt2a (show SLC34A1 Proteins), Npt2c, or PiT-2 (show SLC20A2 Proteins) protein levels during development might also cause hypophosphatemia and rickets in VDR (show CYP27B1 Proteins) (-/-) mice.

  4. Targeting of NaPi-IIc to the apical surface of renal epithelial cells is regulated by a unique amino acid motif in the cytoplasmic C-terminal domain.

  5. Findings suggest that Npt2a (show SLC34A1 Proteins), Npt2c, and PiT-2 (show SLC20A2 Proteins) are necessary for the phosphaturic activity of FGF23 (show FGF23 Proteins).

  6. NaPi-IIc mRNA and protein was up-regulated by the low-Pi diet in all nephron generations analysed

  7. Npt2c maintains normal Ca metabolism, in part by modulating the vitamin D/fibroblast growth factor 23 (show FGF23 Proteins) axis.

  8. Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa (show SLC34A1 Proteins), NaPi-IIc, and PiT-2 (show SLC20A2 Proteins) in dietary potassium deficiency.

  9. FGF23 (show FGF23 Proteins) decreases renal NaPi-2a (show SLC34A1 Proteins) and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.

  10. Npt2a (show SLC34A1 Proteins) and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.

Human Solute Carrier Family 34 (Sodium Phosphate), Member 3 (SLC34A3) interaction partners

  1. This is the report of a patient with compound heterozygous mutations of SLC34A3 and normal skeletal features. Biallelic mutations in SLC34A3 can thus be associated with hypercalciuria not accompanied by rickets.

  2. Individuals with mutations affecting both SLC34A3 alleles had a significantly increased risk of kidney stone formation or medullary nephrocalcinosis, namely 46% compared with 6% observed in healthy family members carrying only the wild-type allele.

  3. this study reports the first cases of hereditary hypophosphatemic rickets with hypercalciuria in Africa and describes a novel causal mutation within the SLC34A3 gene

  4. A man with hereditary hypophosphataemic rickets with hypercalciuria & his 3 heterozygous children had a mutation in intron 5 of gene SLC34A3 (NM_080877.2:c[ 448 +5G>A] + [ 448 +5G>A]).

  5. Data show 101-bp deletion in intron 9 of the SLC34A3 gene.

  6. SLC34A3 mutations (exons and introns) were searched in two previously not reported hereditary hypophosphatemic rickets with hypercalciuria kindreds, which resulted in the identification of three novel mutations.

  7. these data suggest that mutations in SLC34A3 in hereditary hypophosphatemic rickets with hypercalciuria result in defective processing and stability

  8. Functionally important sites in the predicted first and fourth extracellular linkers of the type IIa Na+/Pi cotransporter (NaPi-IIa (show SLC34A1 Proteins)) were identified by cysteine scanning mutagenesis (Ehnes et al., 2004).

  9. NaP(i)-IIc has a key role in the regulation of phosphate homeostasis.

  10. Loss of function of the SLC34A3 protein presumably results in a primary renal tubular defect and is compatible with the hereditary hypophosphatemic rickets with hypercalciuria phenotype.

SLC34A3 Protein Profile

Protein Summary

This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.

Gene names and symbols associated with SLC34A3

  • solute carrier family 34 (sodium phosphate), member 3 (SLC34A3)
  • solute carrier family 34 (sodium phosphate), member 3 (slc34a3)
  • solute carrier family 34 (sodium phosphate), member 3 (Slc34a3)
  • solute carrier family 34 (type II sodium/phosphate contransporter), member 3 (SLC34A3)
  • solute carrier family 34 (type II sodium/phosphate contransporter), member 3 (Slc34a3)
  • AI649385 protein
  • HHRH protein
  • naPi-2c protein
  • Npt2c protein
  • NPTIIc protein

Protein level used designations for SLC34A3

solute carrier family 34 (sodium phosphate), member 3 , sodium-dependent phosphate cotransporter isoform NaPi-IIc , Na(+)-dependent phosphate cotransporter 2C , Na(+)/Pi cotransporter 2C , sodium-dependent phosphate transport protein 2C , sodium-phosphate cotransporter IIC , sodium/phosphate cotransporter 2C , type IIc Na+/Pi-cotransporter , naPi-2c , sodium-phosphate transport protein 2C , sodium/inorganic phosphate cotransporter IIC , type IIc Na+/Pi cotransporter , Na+/Pi-cotransporter type IIc , solute carrier family 34 member 3

GENE ID SPECIES
641343 Sus scrofa
705192 Macaca mulatta
100381095 Xenopus laevis
491232 Canis lupus familiaris
142681 Mus musculus
142680 Homo sapiens
246234 Rattus norvegicus
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