Solute Carrier Family 34 (Sodium Phosphate), Member 1 Proteins (SLC34A1)

SLC34A1 encodes a member of the type II sodium-phosphate cotransporter family.

list all proteins Gene Name GeneID UniProt
Mouse SLC34A1 SLC34A1 20505  
Human SLC34A1 SLC34A1 6569 Q06495
Rat SLC34A1 SLC34A1 25548 Q06496
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More Proteins for Solute Carrier Family 34 (Sodium Phosphate), Member 1 (SLC34A1) Interaction Partners

Mouse (Murine) Solute Carrier Family 34 (Sodium Phosphate), Member 1 (SLC34A1) interaction partners

  1. Results show that urine pyrophosphate (PPI) levels are increased in Npt2a-/- mice when compared to WT, possibly to protect from renal mineralization in the setting of hyperphosphaturia. However, the presence of two hypomorphic Enpp1asj/asj (show ARSJ Proteins) alleles decreases urine PPi and worsens renal calcium phosphate deposit formation in Npt2a-/- mice.

  2. Npt2a-/- mice respond differently to dietary phosphate when compared to WT mice

  3. observed a marked decrease of renal gene expression and urinary excretion of osteopontin (show SPP1 Proteins) in Npt2a(-/-) mice

  4. Analysis of calcium and phosphate metabolism in Slc34a1-knockout mice highlighted the effect of phosphate depletion and fibroblast growth factor-23 suppression on the development of the idiopathic infantile hypercalcemia phenotype.

  5. AC6 (show ADCY6 Proteins) in the proximal tubule modulates cAMP formation, Npt2a trafficking, and urinary phosphate excretion, which are highlighted by renal phosphate wasting in AC6 (show ADCY6 Proteins)(-/-) mice

  6. Downregulation of renal Npt2a expression through induction of plasma iPTH levels alters Pi homeostasis during LPS (show TLR4 Proteins)-induced acute inflammation.

  7. serine 249 of ezrin (show EZR Proteins) can play important roles in the regulation of the complex formation and membrane localization of NaPi-IIa.

  8. Npt2a protein expression in PTH (show PTH Proteins)-D1 mice was decreased relative to control animals, whereas levels of Na-K, NHERF-1 (show SLC9A3R1 Proteins), and PTH (show PTH Proteins) receptor remained unchanged.

  9. The authors conclude that the polyclonal antiserum is specific toward NaPi-IIa in the kidney, but in the brain, immunolabeling is caused by a cross-reaction of the antiserum with an unknown cytosolic protein that is not present in the kidney.

  10. reduced intestinal Pi absorption in VDR (show CYP27B1 Proteins) (-/-) mice does not seem to be the only factor that causes hypophosphatemia; reduced Npt2a, Npt2c (show SLC34A3 Proteins), or PiT-2 (show SLC20A2 Proteins) protein levels during development might also cause hypophosphatemia and rickets in VDR (show CYP27B1 Proteins) (-/-) mice.

Human Solute Carrier Family 34 (Sodium Phosphate), Member 1 (SLC34A1) interaction partners

  1. Biallelic mutations in CYP24A1 (show CYP24A1 Proteins) or SLC34A1 were associated with infantile idiopathic hypercalcemia with vitamin D hypersensitivity

  2. FGFR1c and PTHR signaling pathways converge on NHERF1 (show SLC9A3R1 Proteins) to inhibit PTH (show PTH Proteins)- and FGF23 (show FGF23 Proteins)-sensitive phosphate transport and down-regulate NPT2A.

  3. The identification of autosomal-recessive SLC34A1 mutations in infants with idiopathic infantile hypercalcemia now demonstrates a crucial role of renal sodium-phosphate cotransporter 2A for calcium metabolism as well as phosphate balance in humans

  4. Estrogen downregulated NaPi-IIa only in U20S cells expressing both ERalpha (show ESR1 Proteins) and ERbeta (show ESR2 Proteins), but not in cells expressing either receptor alone.

  5. A novel homozygous mutation in the gene encoding the renal sodium-dependent phosphate transporter SLC34A1 was identified in two siblings with hypercalcemia, hypercalciuria, hypophosphatemia, low parathyroid hormone (PTH (show PTH Proteins)), and nephrocalcinosis.

  6. B-RAF (show SNRPE Proteins) increases the cell surface protein (show CD28 Proteins) abundance and activity of the type II Na+-coupled phosphate transporters NaPi-IIa and NaPi-IIb (show SLC34A2 Proteins).

  7. JAK2 (show JAK2 Proteins) contributes to the regulation of phosphate transporter NaPiIIa

  8. Results indicate that the PDZ1 domain is critical for NHERF1 (show SLC9A3R1 Proteins)-NPT2a interaction in humans and for the control of NPT2a expression at the plasma membrane.

  9. Our cases suggest a contiguous gene deletion syndrome including NSD1 and SLC34A1 and provide a potential genetic basis for idiopathic infantile hypercalcemia.

  10. Results suggest that a 31-kDa nuclear protein (show RDBP Proteins) from kidney-derived cells binds to the C/EBP (show CEBPA Proteins)-like region of the type II Na/Pi-cotransporter promoter.

Solute Carrier Family 34 (Sodium Phosphate), Member 1 (SLC34A1) Protein Profile

Protein Summary

This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SLC34A1

  • solute carrier family 34 (sodium phosphate), member 1 (SLC34A1)
  • solute carrier family 34 (sodium phosphate), member 1 (Slc34a1)
  • solute carrier family 34 (type II sodium/phosphate contransporter), member 1 (SLC34A1)
  • solute carrier family 34 (type II sodium/phosphate contransporter), member 1 (Slc34a1)
  • FRTS2 protein
  • NaPi-2 protein
  • NAPI-3 protein
  • NaPi-IIa protein
  • NaPi2A protein
  • NPHLOP1 protein
  • NPT2 protein
  • Npt2a protein
  • NPTIIa protein
  • SLC11 protein
  • SLC17A2 protein
  • SLC34A1 protein

Protein level used designations for SLC34A1

solute carrier family 34 (sodium phosphate), member 1 , Na/Pi cotransporter NaPi-IIa , Na(+)-dependent phosphate cotransporter 2A , Na(+)/Pi cotransporter 2A , Na/Pi cotransporter , naPi-2a , naPi-7 , renal Na+/Pi transporter , sodium-dependent phosphate transport protein 2A , sodium-phosphate transport protein 2A , sodium/phosphate cotransporter 2A , solute carrier family 17 (sodium/hydrogen exchanger), member 2 , solute carrier family 34 member 1 , type IIa Na+/Pi-cotransporter , naPi-6 , renal sodium-dependent phosphate transporter type II , Na+/phosphate cotransporter , Na+-phosphate cotransporter type II , renal sodium-dependent phosphate transporter , sodium/phosphate co-transporter , solute carrier family 17 (sodium phosphate), member 2 , solute carrier family 17 (sodium/hydrogen exchanger) member 2 , solute carrier family 34, member 1

395402 Gallus gallus
462303 Pan troglodytes
479275 Canis lupus familiaris
20505 Mus musculus
100009392 Oryctolagus cuniculus
443505 Ovis aries
6569 Homo sapiens
25548 Rattus norvegicus
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