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The protein encoded by SLC34A2 is a pH-sensitive sodium-dependent phosphate transporter. Additionally we are shipping SLC34A2 Antibodies (20) and many more products for this protein.
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A sodium-dependent phosphate transporter gene, NaPi-IIb, was isolated from swine small intestine using cDNA library screening method.
This study validated the role of Npt2b in the pathogenesis of Pulmonary alveolar microlithiasis (PAM (show PAM Proteins)).
Overall, our preclinical results suggest that the ADC (show ADC Proteins) targeting NaPi2b provides an effective new therapy for the treatment of NSCLC and ovarian cancer and is currently undergoing clinical developments.
NaPi-IIb is the only luminal Na(+) -dependent Pi transporter in the murine ileum and its absence is fully compensated for in adult females by a mechanism involving the bone-kidney axis.
Knockdown of the sodium-dependent phosphate co-transporter 2b (NPT2b) suppresses lung tumorigenesis.
B-RAF (show SNRPE Proteins) increases the cell surface protein (show CD28 Proteins) abundance and activity of the type II Na+-coupled phosphate transporters NaPi-IIa (show SLC34A1 Proteins) and NaPi-IIb.
that NHERF1 (show SLC9A3R2 Proteins) associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation.
Compared with wild-type uremic mice, Npt2b-deficient uremic mice had significantly lower levels of serum phosphate and attenuation of FGF23 (show FGF23 Proteins).
Npt2b is an important target for the prevention of hyperphosphatemia
In GABARAP (show GABARAP Proteins)-deficient mice renal NaPi-IIa (show SLC34A1 Proteins) is up-regulation and intestinal NaPi-IIb is downregulated.
NaPi-IIb was the predominantly expressed epithelial isoform of the sodium-inorganic phosphate cotransporter and was markedly overexpressed in the proximal region in the infertile knockout compared to the fertile heterozygous c-ros (show ROS1 Proteins) transgenic mouse
SLC34A2 has an important role in promoting proliferation and tumorigenicity of BC.
SLC34A2 was down-regulated in osteosarcoma patients.SLC34A2 interacted with PTEN, and decreased the phosphorylation of PI3K (show PIK3CA Proteins) and AKT (show AKT1 Proteins), which inactivated the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway.
High expression of SLC34A2 was identified in about 2/3 patients and correlated with significantly better patient's overall survival. Epidermal growth factor receptor (show EGFR Proteins) mutations were detected in about 53% of patients with no statistically significant difference to patient's overall survival. Anaplastic lymphoma kinase rearrangement was found in 8 out of 175 patients, harboring this abnormality leads to shorter overall survi
we elucidated that miR (show MLXIP Proteins)-939 exerted its function mainly through inhibiting SLC34A2/Raf (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway, which is activated in GC. Multivariate analysis identified miR (show MLXIP Proteins)-939, SLC34A2, and their combination as independent indicators for poor prognosis and tumor recurrence in GC patients.
a novel role of SLC34A2 inbreast cancer stem cells (BCSCs) state regulation and establishes a rationale for targeting the SLC34A2/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/SOX2 (show SOX2 Proteins) signaling pathway for breast cancer therapy.
Knockdown of SLC34A2 inhibits proliferation.
our work indicated that decreased SLC34A2 expression sensitized BCSCs to doxorubicin via SLC34A2-Bmi1 (show BMI1 Proteins)-ABCC5 (show ABCC5 Proteins) signaling and shed new light on understanding the mechanism of chemoresistance in BCSCs. This study not only bridges the missing link between stem cell-related transcription factor (Bmi1 (show BMI1 Proteins)) and ABC transporter (ABCC5 (show ABCC5 Proteins)) but also contributes to development of potential therapeutics against breast cancer.
Our work sheds new light on the nature of the state of lung cancer stem cell-like cells and the role of SLC34A2 in the tumorigenicity of these cells
SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are powerful stimulators of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb
our data indicated that SLC34A2 could exert significantly suppressive effects on tumorigenesis and progression of NSCLC. SLC34A2 might provide new insights for further understanding the early pathogenesis of human non-small cell lung cancer
The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene.
Na/Pi cotransporter NaPi-IIb
, sodium-dependent phosphate transport protein 2B
, type IIb sodium phosphate cotransporter
, solute carrier family 34 (sodium phosphate), member 2
, sodium-dependent phosphate cotransporter isoform NaPi-IIb
, Na(+)-dependent phosphate cotransporter 2B
, Na(+)/Pi cotransporter 2B
, sodium-phosphate transport protein 2B
, sodium/phosphate cotransporter 2B
, solute carrier family 34 member 2
, type IIb Na/Picotransporter
, type II sodium-dependent phosphate transporter 3b
, rNaPi IIb
, type IIb sodium-phosphate transporter