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SLC35C1 encodes a GDP-fucose transporter that is found in the Golgi apparatus. Additionally we are shipping SLC35C1 Antibodies (7) and and many more products for this protein.
Slc35c1 overexpression causes elevated N-linked fucosylation and disrupts embryonic patterning in a transporter activity dependent manner.
two Turkish siblings with a novel mutation in GDP-fucose transporter and features of congenital disorder of glycosylation IIc
Fx enzyme and GDP-L-Fuc (show FUT8 ELISA Kits) Tr overexpression in the tumur tissue of colorectal cancer (CRC (show CALR ELISA Kits)) patients suggests that GDP-L-Fuc (show FUT8 ELISA Kits) transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC (show CALR ELISA Kits).
In the rare LAD (show DLD ELISA Kits)-II disease, the fucosylation of selectin ligands is disturbed, caused by mutations in SLC35C1, the gene that encodes a GDP-fucose transporter of the Golgi system. (Review)
the conserved glycine residues at positions 180 and 277 of SLC35C1 have significant impacts on lectin binding
In the GDP-fucose transporter a new single nucleotide deletion produced an open-reading frame shift & polypeptide truncation. Overexpression of the mutant protein in fibroblasts did not rescue fucosylation. The deletion ablated transporter activity.
Leukocyte adhesion deficiency II patients display dual defect in functoin ang Golgi expression of FUCT1.
the upregulation of GDP-Fuc Tr plays a pivotal role in increased fucosylation in hepatocellular carcinoma
Slc35c1(-/-) mice show strongly defective leukocyte trafficking but normal lymphocyte homing to the spleen, which may explain normal lymphocyte functions in LAD II.
This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene.
GDP-fucose transporter 1
, GDP-fucose transporter
, solute carrier family 35, member C1
, GDP-fucose transporter 1-like
, golgi GDP-fucose translocator
, solute carrier family 35 member C1
, multispan transmembrane protein fuct1