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SLC36A1 encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. Additionally we are shipping and many more products for this protein.
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Human Polyclonal SLC36A1 Primary Antibody for FACS, IF - ABIN656104
Dorn, Weiwad, Markwardt, Laug, Rudolph, Brandsch, Bosse-Doenecke: Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1. in The Journal of biological chemistry 2009
Show all 2 references for ABIN656104
Sertraline is an apparent non-competitive inhibitor of PAT1-mediated transport.
Data suggest that PAT1 in enterocytes is responsible for intestinal absorption of some of the alkaloids from areca nut (i.e., arecaidine, guvacine, isoguvacine).
estrogen attenuates the activity of PAT1 by directly closing PAT1
In hPAT1 expressing oocytes Gly-Tyr (show TYR Antibodies), Gly-Pro, and Gly-Phe inhibited currents induced by drug substances.
In human cells, SLC36A1 localized on intracellular membranes is required for amino acid-dependent mTORC1 activation and cell proliferation. SLC36A1 also has similar in vivo growth regulatory activity to fly SLC36 AAAPs when expressed in Drosophila.
PAT1 expressed exclusively in apical membrane of Caco-2 cells. hPAT1 may be responsible for H(+)-coupled amino acid transport expressed in apical membrane of Caco-2 cells.
Amino acid uptake via hPAT1 is inhibited by activators of the cAMP pathway indirectly through inhibition of NHE3 (show SLC9A3 Antibodies) activity.
PAT1a (show PATL2 Antibodies), which is 99.0% identical to protein interacting with APP tail 1 (PAT1 (show APPBP2 Antibodies)), is a functional link between the transport and processing of beta-amyloid precursor protein APP and its two paralogs APLP1 (show APLP1 Antibodies) and APLP2 (show APLP2 Antibodies) in vivo.
His-55 might be responsible for binding and translocation of H+ in the course of cellular amino acid uptake by PAT1.
This study is the first to demonstrate both taurine uptake via PAT1 and functional expression of PAT1 at the apical membrane of the intestinal epithelium.
Data suggest that a high-fat diet induces expression of two amino acid transporters (Slc36a1, Slc6a20a) in intestinal mucosa pointing to a specific and adaptive absorption of some amino acids in high-fat diet-induced obesity and glucose intolerance.
detailed analysis of the transport mode of the murine PAT1 in oocytes; PAT1 is an electrogenic H+-coupled amino acid symporter with the capability for bidirectional amino acid transport
The essential role of chloride and fructose absorbing Slc36a1 is reported.
This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.
, lysosomal amino acid transporter 1
, proton-coupled amino acid transporter 1
, proton/amino acid transporter 1
, solute carrier family 36 member 1
, neutral amino acid/proton symporter
, ysosomal amino acid transporter 1