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SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1\\\\; MIM 606561). Additionally we are shipping Solute Carrier Family 36 (Proton/amino Acid Symporter), Member 4 Antibodies (40) and and many more products for this protein.
SLC36A4 has a similar in vivo growth regulatory activity to fly SLC36 family members when expressed in Drosophila and is also required for amino acid-dependent mTORC1 activation, and mTORC1-regulated proliferation in human cells.
SLC36A4 (hPAT4) is a high affinity amino acid transporter (show SLC43A2 ELISA Kits) when expressed in Xenopus laevis oocytes.
Detailed analysis of Slc36a4 mRNA distribution and protein mapping in mouse brain, showing an abundant expression in piriform cortex, hippocampus and hypothalamus in inhibitory and excitatory neurons and epithelial cells lining the ventricles in the brain
A new mechanism of regulation of mTORC1 signalling and autophagy, that is, quality control of PAT4 by Rab12 (show RAB12 ELISA Kits).
SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1\; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011
proton-coupled amino acid transporter 4
, proton/amino acid transporter 4
, solute carrier family 36 member 4