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anti-Solute Carrier Family 39 (Zinc Transporter), Member 8 (SLC39A8) Antibodies

SLC39A8 encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. Additionally we are shipping SLC39A8 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC39A8 67547 Q91W10
SLC39A8 64116 Q9C0K1
Anti-Rat SLC39A8 SLC39A8 295455 Q5FVQ0
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Top anti-SLC39A8 Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow Cytometric analysis of CEM cells using SLC39A8 Antibody (Center) Cat.-No AP53783PU-N (Bottom histogram) compared to a Negative Control cell (Top histogram). FITC-conjugated Goat-anti-Rabbit secondary antibodies were used for the analysis. Western blot analysis in CEM cerebellum cell line lysates (35 ug/lane) using SLC39A8 Antibody (Center) Cat.-No AP53783PU-N. SLC39A8 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of ZIP8 in human spleen tissue lysate with ZIP8 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-SLC39A8 Antibody Titration: 0.2-1 ug/mlPositive Control: NCI-H226 cell lysate WB Suggested Anti-SLC39A8  Antibody Titration: 0.2-1 µg/mL  Positive Control: NCI-H226 cell lysate  There is BioGPS gene expression data showing that SLC39A8 is expressed in NCIH226 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit APC FACS, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB SLC39A8 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$330.00
Details
Human Rabbit Un-conjugated ELISA, WB 0.1 mg Log in to see 6 to 11 Days
$535.71
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$522.50
Details

SLC39A8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Human ,


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Top referenced anti-SLC39A8 Antibodies

  1. Human Polyclonal SLC39A8 Primary Antibody for EIA, FACS - ABIN955673 : Wang, McDonnell, Hebbring, Cunningham, St Sauver, Cerhan, Isaya, Schaid, Thibodeau: Polymorphisms in mitochondrial genes and prostate cancer risk. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008 (PubMed)
    Show all 2 references for ABIN955673

  2. Human Polyclonal SLC39A8 Primary Antibody for EIA, WB - ABIN783809 : Dufner-Beattie, Langmade, Wang, Eide, Andrews: Structure, function, and regulation of a subfamily of mouse zinc transporter genes. in The Journal of biological chemistry 2003 (PubMed)

More Antibodies against SLC39A8 Interaction Partners

Mouse (Murine) Solute Carrier Family 39 (Zinc Transporter), Member 8 (SLC39A8) interaction partners

  1. Findings identify a reciprocal activation mechanism involving HIF-2alpha (show EPAS1 Antibodies) and the zinc-ZIP8-MTF1 (show MTF1 Antibodies) axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.

  2. Data, including data from transgenic mice with high Slc39a8 gene copy number, suggest that early signs of cadmium poisoning (via oral exposure to cadmium chloride) are not exacerbated by increased expression of Slc39a8.

  3. We ligated mouse ZIP14A, ZIP14B and ZIP8 cDNA coding regions into the Xenopus-specific vector pXFRM, transcribed these in vitro, and microinjected the capped RNAs into Xenopus oocytes. K(m) and V(max) values for Cd, Zn and Fe uptake were determined.

  4. The knockdown of ZIP8, ZIP14 (show SLC39A14 Antibodies) or DMT1 (show SLC11A2 Antibodies) by siRNA transfection significantly reduced the uptake of Cd(2 (show CD2 Antibodies)+) and Mn(2+) from the apical membrane.

  5. Observations indicate that ZIP14 and ZIP8 are both broad-scope metal-ion transporters that can mediate the cellular uptake of nutritionally important metals as well as the toxic heavy metal cadmium.

  6. Results show that ZIP8-mediated zinc transport plays an unappreciated critical role during in utero and neonatal growth, organ morphogenesis, and hematopoiesis.

  7. Zinc transporters of the Slc30a/ZnT and Slc39a/Zip families play crucial roles in cell functions, mediating zinc influx to and efflux from the lumen of the secretory pathway, constitutively or in a cell-specific manner. (Review)

  8. We show that-similar to ZIP4-the ZIP8 eight-transmembrane protein is largely internalized during Zn(2+) homeostasis, but moves predominantly to the cell surface membrane (trafficking) under conditions of Zn(2+) depletion.

  9. The present study provides the complete characterization of Slc39a14 (show SLC39A14 Antibodies) gene and its ZIP14 (show SLC39A14 Antibodies) mRNAs and proteins and for the first time demonstrates the significance of ZIP14 (show SLC39A14 Antibodies) in Cd2 (show CCND2 Antibodies)+-mediated cell damage.

  10. The expression of Slc30a1 (show SLC30A1 Antibodies), Slc39a8, and Slc39a10 (show SLC39A10 Antibodies) in the erythrocytes of zinc deficient and replete mice is reported.

Human Solute Carrier Family 39 (Zinc Transporter), Member 8 (SLC39A8) interaction partners

  1. data provide evidence of positive selection on a schizophrenia risk SNP rs13107325 in the SLC39A8 gene, and we propose a hypothesis about the relationship among positive selection of host alleles, schizophrenia, hypertension, energy intake, and the unique history of Europeans.

  2. The lead single nucleotide polymorphism (SNP) in the 4q24 locus was rs13107325 (P-value = 5.1 x 10(-11), beta = -0.77), located in an exon of SLC39A8, which encodes a protein involved in manganese and zinc transport.

  3. Autosomal-recessive intellectual disability with cerebellar atrophy syndrome is caused by mutation of the manganese and zinc transporter gene SLC39A8.

  4. Polymorphisms in SLC39A14 (show SLC39A14 Antibodies) and SLC39A8 seemed to affect blood cadmium concentrations, for SLC39A14 (show SLC39A14 Antibodies) this effect may occur via differential gene expression.

  5. Data indicate that the average expression level of zinc transporter Zip2 was significantly higher and zinc transporters Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls.

  6. MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis

  7. The zinc transporter SLC39A8 (ZIP8) is a transcriptional target of NF-kappaB (show NFKB1 Antibodies) and functions to negatively regulate proinflammatory responses through zinc-mediated down-modulation of IkappaB kinase (show CHUK Antibodies) (IKK (show CHUK Antibodies)) activity in vitro.

  8. data identify ZIP8 as an iron transport protein that may function in iron metabolism.

  9. These data are the first to characterize human SLC39A8 (Zip8) and remarkably demonstrate that upregulation of Zip8 is sufficient to protect lung epithelia against TNF-alpha (show TNF Antibodies)-induced cytotoxicity.

  10. These results demonstrate the importance of Sp1 in the regulation of ZIP8 expression.

SLC39A8 Antigen Profile

Protein Summary

This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with SLC39A8

  • solute carrier family 39 (metal ion transporter), member 8 (Slc39a8) antibody
  • solute carrier family 39 (zinc transporter), member 8 (SLC39A8) antibody
  • solute carrier family 39 (zinc transporter), member 8 (Slc39a8) antibody
  • 4933419D20Rik antibody
  • AA986696 antibody
  • BIGM103 antibody
  • LZT-Hs6 antibody
  • ZIP8 antibody

Protein level used designations for SLC39A8

ZIP-8 , Zrt- and Irt-like protein 8 , solute carrier family 39 member 8 , zinc transporter ZIP8 , BCG induced integral membrane protein BIGM103 , BCG-induced integral membrane protein in monocyte clone 103 protein , LIV-1 subfamily of ZIP zinc transporter 6 , solute carrier family 39 (metal ion transporter), member 8 , zrt- and Irt-like protein 8

GENE ID SPECIES
67547 Mus musculus
64116 Homo sapiens
295455 Rattus norvegicus
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