anti-Solute Carrier Family 39 (Zinc Transporter), Member 8 (SLC39A8) Antibodies

SLC39A8 encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. Additionally we are shipping SLC39A8 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC39A8 67547 Q91W10
SLC39A8 64116 Q9C0K1
SLC39A8 295455 Q5FVQ0
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Top anti-SLC39A8 Antibodies at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow Cytometric analysis of CEM cells using SLC39A8 Antibody (Center) Cat.-No AP53783PU-N (Bottom histogram) compared to a Negative Control cell (Top histogram). FITC-conjugated Goat-anti-Rabbit secondary antibodies were used for the analysis. Western blot analysis in CEM cerebellum cell line lysates (35 ug/lane) using SLC39A8 Antibody (Center) Cat.-No AP53783PU-N. SLC39A8 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-SLC39A8 Antibody Titration: 0.2-1 ug/mlPositive Control: NCI-H226 cell lysate WB Suggested Anti-SLC39A8  Antibody Titration: 0.2-1 µg/mL  Positive Control: NCI-H226 cell lysate  There is BioGPS gene expression data showing that SLC39A8 is expressed in NCIH226 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Horse Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, IHC (p), WB Immunohistochemistry: SLC39A8/ZIP8 Antibody [NBP1-76505] - Human spleen tissue with ZIP8 antibody at 5-20ug/ml. Western Blot: SLC39A8/ZIP8 Antibody [NBP1-76505] - Human spleen tissue lysate with SLC39A8/ZIP8 antibody at (A) 1 and (B) 2 ug/mL. 0.1 mg Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry-Paraffin: SLC39A8/ZIP8 Antibody [NBP2-34058] - liver Immunohistochemistry-Paraffin: SLC39A8/ZIP8 Antibody [NBP2-34058] - Immunohistochemical staining of human placenta shows distinct membranous positivity in syncytiotrophoblasts. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: SLC39A8/ZIP8 Antibody [NBP1-59601] - Human Pancreas (Cancer) & rat pancreas, 6.6 ug/ml. Western Blot: SLC39A8/ZIP8 Antibody [NBP1-59601] - NCI-H226 cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 7 to 9 Days
$537.17
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$340.00
Details
Human Rabbit Un-conjugated WB SLC39A8 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
$473.93
Details

SLC39A8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Human ,


, , , , ,
Rat (Rattus)


Top referenced anti-SLC39A8 Antibodies

  1. Human Polyclonal SLC39A8 Primary Antibody for EIA, FACS - ABIN955673 : Wang, McDonnell, Hebbring, Cunningham, St Sauver, Cerhan, Isaya, Schaid, Thibodeau: Polymorphisms in mitochondrial genes and prostate cancer risk. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008 (PubMed)
    Show all 2 references for 955673

More Antibodies against SLC39A8 Interaction Partners

Mouse (Murine) Solute Carrier Family 39 (Zinc Transporter), Member 8 (SLC39A8) interaction partners

  1. ZIP8 reclaims Mn from bile and regulates whole-body Mn homeostasis.

  2. Intravitreal holo-transferrin (show Tf Antibodies) injection decreased Zip 14 (show SLC39A14 Antibodies) protein levels. These data indicate that Zip8 and Zip14 (show SLC39A14 Antibodies) may take up increasing amounts of non-transferrin (show Tf Antibodies) bound iron in these two mouse models of retinal iron accumulation.

  3. Findings identify a reciprocal activation mechanism involving HIF-2alpha (show EPAS1 Antibodies) and the zinc-ZIP8-MTF1 (show MTF1 Antibodies) axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.

  4. Data, including data from transgenic mice with high Slc39a8 gene copy number, suggest that early signs of cadmium poisoning (via oral exposure to cadmium chloride) are not exacerbated by increased expression of Slc39a8.

  5. We ligated mouse ZIP14A, ZIP14B and ZIP8 cDNA coding regions into the Xenopus-specific vector pXFRM, transcribed these in vitro, and microinjected the capped RNAs into Xenopus oocytes. K(m) and V(max) values for Cd, Zn and Fe uptake were determined.

  6. The knockdown of ZIP8, ZIP14 (show SLC39A14 Antibodies) or DMT1 (show SLC11A2 Antibodies) by siRNA transfection significantly reduced the uptake of Cd(2 (show CD2 Antibodies)+) and Mn(2+) from the apical membrane.

  7. Observations indicate that ZIP14 and ZIP8 are both broad-scope metal-ion transporters that can mediate the cellular uptake of nutritionally important metals as well as the toxic heavy metal cadmium.

  8. Results show that ZIP8-mediated zinc transport plays an unappreciated critical role during in utero and neonatal growth, organ morphogenesis, and hematopoiesis.

  9. Zinc transporters of the Slc30a/ZnT and Slc39a/Zip families play crucial roles in cell functions, mediating zinc influx to and efflux from the lumen of the secretory pathway, constitutively or in a cell-specific manner. (Review)

  10. We show that-similar to ZIP4-the ZIP8 eight-transmembrane protein is largely internalized during Zn(2+) homeostasis, but moves predominantly to the cell surface membrane (trafficking) under conditions of Zn(2+) depletion.

Human Solute Carrier Family 39 (Zinc Transporter), Member 8 (SLC39A8) interaction partners

  1. These results indicate that the ZIP8 Ala391-to-Thr391 substitution has an effect on intracellular cadmium accumulation and cell toxicity, providing a potential mechanistic explanation for the association of this genetic variant with blood pressure.

  2. We identified an association between Crohn's Disease and a missense variant encoding alanine or threonine at position 391 in the zinc transporter solute carrier (show SERTAD2 Antibodies) family 39, member 8 protein (SLC39A8 alanine 391 threonine, rs13107325) and replicated the association with Crohn's Disease in 2 replication cohorts.

  3. SLC39A8 SNP (rs13107325) was associated with NT-proBNP levels in patients with acute coronary syndrome (ACS (show PLA2G15 Antibodies)). The SLC39A8 SNP was also associated with higher risk of cardiovascular death.

  4. data provide evidence of positive selection on a schizophrenia risk SNP rs13107325 in the SLC39A8 gene, and we propose a hypothesis about the relationship among positive selection of host alleles, schizophrenia, hypertension, energy intake, and the unique history of Europeans.

  5. The lead single nucleotide polymorphism (SNP) in the 4q24 locus was rs13107325 (P-value = 5.1 x 10(-11), beta = -0.77), located in an exon of SLC39A8, which encodes a protein involved in manganese and zinc transport.

  6. Autosomal-recessive intellectual disability with cerebellar atrophy syndrome is caused by mutation of the manganese and zinc transporter gene SLC39A8.

  7. Polymorphisms in SLC39A14 (show SLC39A14 Antibodies) and SLC39A8 seemed to affect blood cadmium concentrations, for SLC39A14 (show SLC39A14 Antibodies) this effect may occur via differential gene expression.

  8. Data indicate that the average expression level of zinc transporter Zip2 was significantly higher and zinc transporters Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls.

  9. MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis

  10. The zinc transporter SLC39A8 (ZIP8) is a transcriptional target of NF-kappaB (show NFKB1 Antibodies) and functions to negatively regulate proinflammatory responses through zinc-mediated down-modulation of IkappaB kinase (show CHUK Antibodies) (IKK (show CHUK Antibodies)) activity in vitro.

SLC39A8 Antigen Profile

Protein Summary

This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with SLC39A8

  • solute carrier family 39 (metal ion transporter), member 8 (Slc39a8) antibody
  • solute carrier family 39 (zinc transporter), member 8 (SLC39A8) antibody
  • solute carrier family 39 (zinc transporter), member 8 (Slc39a8) antibody
  • 4933419D20Rik antibody
  • AA986696 antibody
  • BIGM103 antibody
  • LZT-Hs6 antibody
  • ZIP8 antibody

Protein level used designations for SLC39A8

ZIP-8 , Zrt- and Irt-like protein 8 , solute carrier family 39 member 8 , zinc transporter ZIP8 , BCG induced integral membrane protein BIGM103 , BCG-induced integral membrane protein in monocyte clone 103 protein , LIV-1 subfamily of ZIP zinc transporter 6 , solute carrier family 39 (metal ion transporter), member 8 , zrt- and Irt-like protein 8

GENE ID SPECIES
67547 Mus musculus
64116 Homo sapiens
295455 Rattus norvegicus
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