Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) ELISA Kits

The protein encoded by SLC4A1 is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. Additionally we are shipping Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) Antibodies (33) and Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SLC4A1 SLC4A1 6521 P02730
Anti-Mouse SLC4A1 SLC4A1 20533 P04919
Anti-Rat SLC4A1 SLC4A1 24779 P23562
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More ELISA Kits for Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) Interaction Partners

Human Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) interaction partners

  1. study reports the R589H mutation in SLC4A1 gene in families with hereditary distal renal tubular acidosis for the first time in China

  2. Forced FOG1 protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 protein, but repressed that of transcription factor PU.1.

  3. Nonsense mutation in exon 12 of SLC4A1 gene is associated with severe hemolytic anemia, dyserythropoiesis and complete distal renal tubular acidosis.

  4. While weak interactions between glycophorin and band 3 undoubtedly exist, glycophorin A (show GYPA ELISA Kits) and band 3 must have separate interactions in the membrane that control their lateral mobility.

  5. three merozoite proteins (PvTRAg36, PvATRAg74, and PvTRAg38) of this family interact with Band 3 on human erythrocytes through its three exofacial loops.

  6. with exacerbation of the oxidative stress during vaso-occlusive crises in sickle cell anaemia patients, the higher concentration of harmful circulating RBC (show CACNA1C ELISA Kits)-derived microparticles and the reduced anti-band 3 autoantibodies levels may be both related to the recruitment of oxidized band 3 into membrane aggregates.

  7. We propose that, in polarized renal epithelial cells, the apically mistargeted kAE1 (show OSGEP ELISA Kits) R901X mutant is endocytosed faster than kAE1 (show OSGEP ELISA Kits) WT and its recycling to the basolateral membrane is delayed. This resets the equilibrium, such that kAE1 (show OSGEP ELISA Kits) R901X resides predominantly in an endomembrane compartment, thereby likely participating in development of dRTA disease.

  8. The conformational dynamics of signal-anchor transmembrane segment 1 of SLC4A1 protein of the Southeast Asian ovalocytosis red blood cells has been reported.

  9. Data indicate that the interaction of Zn(2+) ion with His-651 residue of band 3 plays an important role in the Zn(2+)-induced agglutination of erythrocytes.

  10. Syk (show SYK ELISA Kits) inhibitor suppressed the phosphorylation of band 3 also preventing serine phosphorylation changes and hemolysis.

Mouse (Murine) Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) interaction partners

  1. properties are controlled by the O2-dependent association of hemoglobin (show HBB ELISA Kits) with band 3

  2. NH4Cl loading elicited adaptive doubling of AE1 mRNA in GPR4 (show GPR4 ELISA Kits)+/+, but a 50% less pronounced response in GPR4 (show GPR4 ELISA Kits)-/-.

  3. Activities of AE1 and the sodium pump are coregulated in kidney.

  4. AE1 is enhanced by acidosis, NaCl, and the combination of DOCA and NaHCO3 in renal collecting ducts.

  5. These findings indicate that the conserved YXXPhi sequence or a noncanonical YXXXPhi sequence in the N-terminal region facilitates the endocytic recycling of erythroid AE1 through a clathrin-mediated pathway.

  6. These results suggest that AE1 is potentially a key therapeutic target and the silencing of AE1 expression in gastric mucosa could provide a new therapeutic approach for treating gastric cancer.

  7. These results demonstrate that mammalian erythroblast enucleation does not depend on the membrane integrity generated by the ankyrin-band 3 complex.

  8. Data suggest that glycophorin A (Gpa (show GYPA ELISA Kits)) increases expression and activity of Cl-/HCO3- exchanger Ae1, that G719D mutation renders Ae1 mutant constructs GPA (show GYPA ELISA Kits)-unresponsive, and suggests a role for Ae1 amino acids 22-28 in GPA (show GYPA ELISA Kits) responsiveness.

  9. podocyte protein kidney anion exchanger 1 interacts with nephrin (show NPHS1 ELISA Kits) and kinase to maintain the structure and function of the glomerular basement membrane.

  10. This review explores what is known about the erythrocyte membrane protein band 3 complexes of mice and humans, focussing on the observed species differences and their potential functional consequences.

Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) Antigen Profile

Antigen Summary

The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.

Gene names and symbols associated with SLC4A1

  • solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (SLC4A1) antibody
  • solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (slc4a1) antibody
  • Band 3 (LOC100136769) antibody
  • solute carrier family 4 (anion exchanger), member 1 (SLC4A1) antibody
  • solute carrier family 4 (anion exchanger), member 1 (Slc4a1) antibody
  • solute carrier family 4, anion exchanger, member 1 (SLC4A1) antibody
  • Ae1 antibody
  • BND3 antibody
  • CD233 antibody
  • DI antibody
  • EAT antibody
  • Empb3 antibody
  • EPB3 antibody
  • FR antibody
  • l11Jus51 antibody
  • LOC100136769 antibody
  • MGC80391 antibody
  • RTA1A antibody
  • slc4a1 antibody
  • SW antibody
  • WD antibody
  • WD1 antibody
  • WR antibody

Protein level used designations for SLC4A1

solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) , erythroid anion exchanger 1 , band 3 anion transport protein , solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3) , Band 3 , band 3 anion transport protein-like , Diego blood group , Froese blood group , Swann blood group , Waldner blood group , Wright blood group , anion exchange protein 1 , anion exchanger 1 , anion exchanger-1 , erythrocyte membrane protein band 3 , erythroid anion exchange protein , solute carrier family 4, anion exchanger, number 1 , AE 1 , MEB3 , solute carrier family 4 member 1 , Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3) , erythrocyte anion transport protein

GENE ID SPECIES
395371 Gallus gallus
443978 Xenopus laevis
454727 Pan troglodytes
100009691 Equus caballus
100136769 Oncorhynchus mykiss
100174401 Pongo abelii
100349024 Oryctolagus cuniculus
100483431 Ailuropoda melanoleuca
100486998 Xenopus (Silurana) tropicalis
100514249 Sus scrofa
490939 Canis lupus familiaris
100563543 Anolis carolinensis
100579389 Nomascus leucogenys
6521 Homo sapiens
20533 Mus musculus
24779 Rattus norvegicus
396532 Gallus gallus
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