Solute Carrier Family 4, Anion Exchanger, Member 2 (erythrocyte Membrane Protein Band 3-Like 1) (SLC4A2) ELISA Kits

Plasma membrane anion exchange protein of wide distribution.. Additionally we are shipping SLC4A2 Antibodies (41) and SLC4A2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SLC4A2 SLC4A2 6522 P04920
Anti-Mouse SLC4A2 SLC4A2 20535 P13808
Anti-Rat SLC4A2 SLC4A2 24780 P23347
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More ELISA Kits for SLC4A2 Interaction Partners

Human Solute Carrier Family 4, Anion Exchanger, Member 2 (erythrocyte Membrane Protein Band 3-Like 1) (SLC4A2) interaction partners

  1. ABA transport in human nucleated cells occurs via the anion exchanger AE2

  2. down-regulation in primary biliary cholangitis sensitizes cholangiocytes to apoptotic insults by activating soluble adenylyl cyclase (show ADCY10 ELISA Kits)

  3. AE2 is a major pathway for basolateral Cl(-) loading during cAMP-stimulated secretion of Cl(-) and fluid by Calu (show CALU ELISA Kits)-3 cells

  4. A novel signal pathway involved in gastrin (show GAST ELISA Kits)-stimulated AE2 expression mediated by EGR1 (show EGR1 ELISA Kits) in gastric cancer cells.

  5. miR (show MLXIP ELISA Kits)-506 is up-regulated in primary biliary cirrhosis, binds the 3'UTR (show UTS2R ELISA Kits) region of AE2 mRNA, and prevents protein translation, leading to diminished AE2 activity and impaired biliary secretory functions.

  6. CTLA4 (show CTLA4 ELISA Kits) and SLC4A2 genetic polymorphisms are differentially associated with primary biliary cirrhosis development and progression, as well as anti-gp210 (show NUP210 ELISA Kits) or anti-centromere antibody production, in Japanese PBC (show DLAT ELISA Kits) patients

  7. Dysfunctions related to AE2 might have a role in the pathogenesis of primary biliary cirrhosis.

  8. AE2 mediated-apoptosis of endothelial cells induced by high glucose was Caspase-3 (show CASP3 ELISA Kits)-dependent.

  9. AE2 operates in parallel with NHE1 (show SLC9A1 ELISA Kits) to regulate pH(i) during RVD of human cervical cancer cells.

  10. Oxidative stress activates anion exchange protein 2 and AP-1 (show FOSB ELISA Kits) in airway epithelial cells.

Cow (Bovine) Solute Carrier Family 4, Anion Exchanger, Member 2 (erythrocyte Membrane Protein Band 3-Like 1) (SLC4A2) interaction partners

  1. These results indicate that a deletion mutation within bovine SLC4A2 is associated with osteopetrosis (show CSF1 ELISA Kits) in Red Angus cattle.

Mouse (Murine) Solute Carrier Family 4, Anion Exchanger, Member 2 (erythrocyte Membrane Protein Band 3-Like 1) (SLC4A2) interaction partners

  1. results strongly suggest that Ae2 is a critical factor in the innate response to C. albicans. This study represents an important contribution to a better understanding of how Dectin-1 (show CLEC7A ELISA Kits) expression and fungal clearance is regulated.

  2. Data indicate a key functional role of anion exchanger 2 (AE2) in the maintenance of the normal physiology of biliary epithelial cells (BEC) and the pathogenic consequences of reduced AE2 expression, including abnormal intrinsic characteristics of BEC and their production of signal molecules that lead to the chronic inflammatory responses in small bile ducts.

  3. AE2 deficiency results in intrahepatic T-cell activation and PD-1 (show PDCD1 ELISA Kits)/PD-L1 (show CD274 ELISA Kits) mediated deletion, favoring autoimmune cholangitis.

  4. GnRH (show GNRH1 ELISA Kits) neurons were immunopositive for NKCC1 (show SLC12A2 ELISA Kits) and AE2.

  5. These findings demonstrate that CD8 (show CD8A ELISA Kits)(+) T cells are critically dependent on Ae2 for pHi homeostasis and tuning of cell proliferation and activation. Ae2 thus constitutes a novel target to modulate CD8 (show CD8A ELISA Kits)(+) T-cell responses.

  6. Rescue of SLC4A2-deficient osteoclasts with functionally defined mutants of SLC4A2 indicates regulation of actin cytoskeletal reorganization by anion-exchange activity and intracellular pH, independent of SLC4A2's long N-terminal cytoplasmic domain.

  7. expression of Slc4a2 significantly decreased in enamel organs from Mmp20 (show MMP20 ELISA Kits)(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development.

  8. AE2 is a component of the basolateral ion transport mechanisms that support anion secretion in the proximal colon.

  9. GFP-tagged Ae2 localization depends upon MAPK (show MAPK1 ELISA Kits) activity

  10. results are consistent with the hypothesis that AE2 mediates the major portion of the exchange across the basolateral membrane of mouse parotid and sublingual acinar cells

SLC4A2 Antigen Profile

Antigen Summary

This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. DUF1220 copy number variations in human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes.

Gene names and symbols associated with SLC4A2

  • solute carrier family 4 (anion exchanger), member 2 (SLC4A2) antibody
  • solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) (SLC4A2) antibody
  • solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) (LOC100224615) antibody
  • neuroblastoma breakpoint family, member 3 (NBPF3) antibody
  • solute carrier family 4 (anion exchanger), member 2 (Slc4a2) antibody
  • Ae2 antibody
  • Aep2 antibody
  • B3RP antibody
  • BND3L antibody
  • EPB3L1 antibody
  • HKB3 antibody
  • NBND3 antibody
  • SLC4A2 antibody

Protein level used designations for SLC4A2

AE 2 , anion exchange protein 2 , anion exchanger 2 type a , anion exchanger 2 type b1 , anion exchanger 2 type b2 , erythrocyte membrane protein band 3-like 1 , non-erythroid band 3-like protein , solute carrier family 4 member 2 , AE2-1 anion exchanger , chloride-bicarbonate anion exchanger AE2 , SLC4A2 anion exchanger , chloride-bicarbonate exchanger , solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) , anion exchanger 2 , band 3-related protein , neuroblastoma breakpoint family member 3 , protein SHIIIa4 , B3RP-2 , Solute carrier family 4, member 2, anion exchange protein 2 , band 3-related protein 2 , AE2 anion exchanger , anion exchanger 2 a

GENE ID SPECIES
6522 Homo sapiens
395809 Gallus gallus
397203 Sus scrofa
404084 Bos taurus
463890 Pan troglodytes
475538 Canis lupus familiaris
713966 Macaca mulatta
100009159 Oryctolagus cuniculus
100172030 Pongo abelii
100224615 Taeniopygia guttata
100599599 Nomascus leucogenys
84224 Homo sapiens
20535 Mus musculus
24780 Rattus norvegicus
100135618 Cavia porcellus
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