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This locus encodes a sodium bicarbonate cotransporter. Additionally we are shipping SLC4A7 Proteins (6) and many more products for this protein.
Showing 10 out of 47 products:
Upregulation of NBCn1 during human breast carcinogenesis contributes to the characteristic acid distribution within human breast carcinomas.
A meta-analysis of genome-wide association studies of blood pressure and hypertension in Chinese identified three new loci (CACNA1D (show CACNA1D Antibodies), CYP21A2 (show CYP21A2 Antibodies), and MED13L (show MED13L Antibodies)) and a newly discovered variant near SLC4A7.
We demonstrate, for the first time, that 3 different pHi regulators responsible for acid extruding, i.e. NHE and NBC (show SLC4A4 Antibodies), and MCT (show MCAT Antibodies), are functionally co-existed in cultured radial artery smooth muscle cells.
The SLC4A7 variant rs4973768 is associated with breast cancer risk.
Simultaneous switching of the putative transmembrane segment (TM6) and TM12 of NBCe1 (show SLC4A4 Antibodies) for those from NBCn1 severely impairs the expression of the transporter at the plasma membrane.
Data show that DeltaNErbB2 expression elicited Na(+), HCO(3)(-) cotransporter NBCn1 upregulation, Ser (show SIGLEC1 Antibodies)(703)-phosphorylation of Na(+)/H(+) exchanger NHE1 (show SLC9A1 Antibodies).
The present study generated a series of chimeras of human NBCe1 (show SLC4A4 Antibodies)-A and human NBCn1-A (SLC4A7). Replacing the fourth extracellular loop (EL4) of human NBCe1 (show SLC4A4 Antibodies)-A with EL4 of NBCn1-A creates an electroneutral NBC (show SLC4A4 Antibodies).
NBCn1 inhibition attenuated cathepsin release and had no net effect on viability of MCF7 cells.
The cystic fibrosis transmembrane conductance regulator (show CFTR Antibodies) interacts with and regulates the activity of the bicarbonate salvage trransporter isoform 3
NBC3 and CAII (show CA2 Antibodies) interact to maximize the HCO(3)(-) transport rate. Although PKA decreased NBC3 transport activity, it did so independently of the NBC3/CAII (show CA2 Antibodies) interaction and did not involve phosphorylation of NBC3Ct.
NBCn1 facilitates acid extrusion from breast cancer tissue, maintains the alkaline intracellular environment and promotes aggressive cancer development and growth
The electroneutral Na+-HCO3- cotransporter (show SLC4A4 Antibodies) NBCn1 plays an essential role in murine duodenal acid-base balance and colonic mucus layer build-up in vivo
Slc4a7 is a major regulator of basal and FSK-stimulated duodenal HCO3 secretion
Intracellular acidification of vascular smooth muscle and endothelial cells after knockout of NBCn1 inhibits nitric oxide-mediates signaling in isolated arteries and perturbs blood pressure regulation.
Damage of the sensory epithelia at the high frequency zone of the cochlea suggests that NBC3 may play an important physiological role in this region.
NBCn1 mediates the Na+-dependent bicarbonate transport important for pH(i) regulation in smooth muscle cells of mouse mesenteric, coronary, and cerebral small arteries.
most cases, hypoxia reduced NBCn1 levels by 20-50%, and NCBE levels by 15-40% in cerebral cortex, subcortex, cerebellum, and hippocampus, both after 14 and 28 days, and in both pups and adults.
We conclude that NBCn1 has a broad expression profile, supporting previous findings based on immunoreactivity, and suggest several new tissues where NBCn1 may be important.
This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described.
solute carrier family 4, sodium bicarbonate cotransporter, member 7
, sodium bicarbonate cotransporter 3
, sodium bicarbonate cotransporter 3-like
, bicarbonate transporter
, sodium bicarbonate cotransporter 2
, sodium bicarbonate cotransporter 2b
, solute carrier family 4 member 7
, Na-bicarbonate cotransporter
, NBC-like protein
, electroneutral sodium bicarbonate cotransporter 1