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The protein encoded by SLC40A1 is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Additionally we are shipping Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Kits (34) and Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Proteins (5) and many more products for this protein.
Showing 10 out of 84 products:
Human Polyclonal SLC40A1 Primary Antibody for ICC, FACS - ABIN439384
Vanoaica, Darshan, Richman, Schümann, Kühn: Intestinal ferritin H is required for an accurate control of iron absorption. in Cell metabolism 2010
Show all 20 references for ABIN439384
Arabidopsis thaliana Polyclonal SLC40A1 Primary Antibody for ELISA, WB - ABIN349669
Kawachi, Kobae, Mimura, Maeshima: Deletion of a histidine-rich loop of AtMTP1, a vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, stimulates the transport activity. in The Journal of biological chemistry 2008
Show all 2 references for ABIN349669
Arabidopsis thaliana Polyclonal SLC40A1 Primary Antibody for WB - ABIN1110330
Selote, Samira, Matthiadis, Gillikin, Long: Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors. in Plant physiology 2015
Show all 2 references for ABIN1110330
Human Polyclonal SLC40A1 Primary Antibody for ELISA, WB - ABIN4311379
Qiao, Sugianto, Fung, Del-Castillo-Rueda, Moran-Jimenez, Ganz, Nemeth: Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. in Cell metabolism 2012
Human Polyclonal SLC40A1 Primary Antibody for FACS - ABIN4311374
Marques, Porto, Rêma, Faria, Cruz Paula, Gomez-Lazaro, Silva, Martins da Silva, Lopes: Local iron homeostasis in the breast ductal carcinoma microenvironment. in BMC cancer 2016
Functional impact of mammalian ferroportin mutations studied in zebrafish.
role of ABCG37, IRT1 and FRO2 in root Fe2+ transport systems
role of IRT1 (show PARP3 Antibodies) in iron uptake
these results suggest that the His-loop of MTP1 acts as a sensor of cytosolic zinc to maintain an essential level in the cytosol and that the dysfunction of the loop results in an uncontrolled accumulation of zinc in the vacuoles of root cells.
Our results reveal a role of SNX1 (show SNX1 Antibodies) for the correct trafficking of IRT1 (show PARP3 Antibodies) and, thus, for modulating the activity of the iron uptake machinery
This work establishes a functional link between the dynamics and the lateral polarity of IRT1 (show PARP3 Antibodies) and the transport of its substrates, and identifies a molecular mechanism driving polar localization of a cell surface protein (show CD28 Antibodies) in plants.
IDF1 directly regulates IRT1 (show PARP3 Antibodies) degradation through its RING-type E3 ligase activity.
Data indicate that steady-state mRNA abundance for three representative Fe homeostasis genes, IRT1 (show PARP3 Antibodies), bHLH39, and FER1 (show FTH1 Antibodies), oscillated in light/dark (LD) cycles or warm/cold environmental cycles.
AtIRT1 transports nicekl (Ni(2 (show VMP1 Antibodies)+)) in roots, and strongly suggest that Ni accumulation is further accelerated by AtIRT1 that is expressed in response to excess Ni.
These data suggest a model in which monoubiquitin-dependent internalization/sorting and turnover keep the plasma membrane pool of IRT1 (show PARP3 Antibodies) low to ensure proper iron uptake and to prevent metal toxicity.
IRT1 and FRO2 genes are upregulated under iron starvation.
All these findings suggest that in erythroid cells FPN1 could be part of the signaling pathway through which the erythron communicates iron needs to expand the erythroid compartment regardless of systemic iron level.
Mir (show MLXIP Antibodies)-20a controls expression of the iron exporter ferroportin (FPN1) by binding to highly conserved target sites in its 3'-untranslated region. Expression of miR (show MLXIP Antibodies)-20a is inversely correlated to FPN1 in lung cancer.
The concentration of functional membrane-associated ferroportin is controlled by its ligand, the iron-regulatory hormone hepcidin (show HAMP Antibodies), and fine-tuned by regulatory mechanisms serving iron homeostasis, oxygen utilization, host defense, and erythropoiesis.
Low hepcidin (show HAMP Antibodies) and high ferroportin expression by erythroblasts and macrophages were seen in iron deficiency anemia, while the opposite was true in anemia of chronic disorders.
Erythroblasts from Beta-thalassemia patients showed a significantly reduced expression of total MTP1 protein.
Several family members had hemochromatosis (show HFE Antibodies) and hyperferritinemia associated with a SLC40A1 deletion in exon 5(485_487delTTG) resulting in the deletion of a valine residue (p.V162del). This is the 1st Spanish family reported with this European mutation.
TLR4 (show TLR4 Antibodies) dependent macrophage signaling is controlled via hepcidin (show HAMP Antibodies)-ferroportin1 axis by influencing TLR4 (show TLR4 Antibodies)-lipid raft interactions
study of healthy adults provides further evidence that ferroportin Q248H mutation affects serum ferritin (show FTL Antibodies) concentration in Africans
Single nucleotide polymorphisms in HAMP (show HAMP Antibodies), BMP2 (show BMP2 Antibodies), FTL (show FTL Antibodies) and SLC40A1 genes have phenotype-modifying roles in hereditary hemochromatosis (show HFE Antibodies) type 1.
Decreased expression of hepcidin (show HAMP Antibodies) and ferroportin in hepatitis C patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon (show IFNA Antibodies) plus ribavirin treatment.
The results suggest that physiologic hepcidin (show HAMP Antibodies) levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.
In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 Antibodies) and ferroportin expression levels were increased and hepatic hepcidin (show HAMP Antibodies) mRNA expression and serum hepcidin (show HAMP Antibodies) concentration were reduced.
Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron.
Results suggest that reduction in ferroportin levels in Alzheimer's disease brains are likely associated with cerebral ischaemia, inflammation, loss of neurons due to protein misfolding, senile plaque formation and possibly ageing process itself
Oral iron failed to be utilized by Fpn-KO mice and was retained in enterocytes, irrespective of the iron source. Ferroportin-dependent efflux from enterocytes controls duodenal iron absorption.
Genetic interactions between Cp, Mon1a (show MON1A Antibodies), and the Slc40a1 locus are involved in iron metabolism.
Hypoxia signal, stimulated erythropoietin (show EPO Antibodies), which affected iron absorption by stabilizing duodenal ferroportin.
A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (show HAMP Antibodies) remains labile and available to down-regulate Fpn1.
Nitric oxide up-regulated the expression of ferroportin-1 (Fpn1), the major cellular iron exporter, in mouse and human cells.
Ferroportin transcription following experimentally-induced acute anemia in mice is tissue-specific.
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).
, iron-regulated transporter
, solute carrier family 39 (iron-regulated transporter), member 1
, solute carrier family 40 member 1
, solute carrier family 40 (iron-regulated transporter), member 1
, solute carrier family 40 member 1-like
, iron regulated gene 1
, putative ferroportin 1 variant IIIB
, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
, SLC11A3 iron transporter
, ferroportin 1
, iron-regulated transporter 1
, metal transporter protein 1
, metal transporting protein 1
, cell adhesion regulator