You are viewing an incomplete version of our website. Please click to reload the website as full version.

Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Proteins (SLC40A1)

The protein encoded by SLC40A1 is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Additionally we are shipping Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Antibodies (82) and Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC40A1 30061 Q9NP59
SLC40A1 53945 Q9JHI9
Rat SLC40A1 SLC40A1 170840 Q923U9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$794.65
Details

SLC40A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) Interaction Partners

Zebrafish Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

  1. Functional impact of mammalian ferroportin mutations studied in zebrafish.

Arabidopsis thaliana Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

  1. role of IRT1 (show PARP3 Proteins) in iron uptake

  2. these results suggest that the His-loop of MTP1 acts as a sensor of cytosolic zinc to maintain an essential level in the cytosol and that the dysfunction of the loop results in an uncontrolled accumulation of zinc in the vacuoles of root cells.

  3. Our results reveal a role of SNX1 (show SNX1 Proteins) for the correct trafficking of IRT1 (show PARP3 Proteins) and, thus, for modulating the activity of the iron uptake machinery

  4. This work establishes a functional link between the dynamics and the lateral polarity of IRT1 (show PARP3 Proteins) and the transport of its substrates, and identifies a molecular mechanism driving polar localization of a cell surface protein (show CD28 Proteins) in plants.

  5. IDF1 directly regulates IRT1 (show PARP3 Proteins) degradation through its RING-type E3 ligase activity.

  6. Data indicate that steady-state mRNA abundance for three representative Fe homeostasis genes, IRT1 (show PARP3 Proteins), bHLH39, and FER1 (show FTH1 Proteins), oscillated in light/dark (LD) cycles or warm/cold environmental cycles.

  7. AtIRT1 transports nicekl (Ni(2 (show VMP1 Proteins)+)) in roots, and strongly suggest that Ni accumulation is further accelerated by AtIRT1 that is expressed in response to excess Ni.

  8. These data suggest a model in which monoubiquitin-dependent internalization/sorting and turnover keep the plasma membrane pool of IRT1 (show PARP3 Proteins) low to ensure proper iron uptake and to prevent metal toxicity.

  9. IRT1 and FRO2 genes are upregulated under iron starvation.

  10. Application of the lipoxygenase inhibitor ibuprofene to plants caused an up-regulation of IRT1 (show PARP3 Proteins) gene expression.

Human Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

  1. The concentration of functional membrane-associated ferroportin is controlled by its ligand, the iron-regulatory hormone hepcidin (show HAMP Proteins), and fine-tuned by regulatory mechanisms serving iron homeostasis, oxygen utilization, host defense, and erythropoiesis.

  2. Low hepcidin (show HAMP Proteins) and high ferroportin expression by erythroblasts and macrophages were seen in iron deficiency anemia, while the opposite was true in anemia of chronic disorders.

  3. Erythroblasts from Beta-thalassemia patients showed a significantly reduced expression of total MTP1 protein.

  4. Several family members had hemochromatosis (show HFE Proteins) and hyperferritinemia associated with a SLC40A1 deletion in exon 5(485_487delTTG) resulting in the deletion of a valine residue (p.V162del). This is the 1st Spanish family reported with this European mutation.

  5. TLR4 (show TLR4 Proteins) dependent macrophage signaling is controlled via hepcidin (show HAMP Proteins)-ferroportin1 axis by influencing TLR4 (show TLR4 Proteins)-lipid raft interactions

  6. study of healthy adults provides further evidence that ferroportin Q248H mutation affects serum ferritin (show FTL Proteins) concentration in Africans

  7. Single nucleotide polymorphisms in HAMP (show HAMP Proteins), BMP2 (show BMP2 Proteins), FTL (show FTL Proteins) and SLC40A1 genes have phenotype-modifying roles in hereditary hemochromatosis (show HFE Proteins) type 1.

  8. Decreased expression of hepcidin (show HAMP Proteins) and ferroportin in hepatitis C patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon (show IFNA Proteins) plus ribavirin treatment.

  9. Data indicate that elevated miR (show MLXIP Proteins)-492 expression in prostate tumors that resulted in diminished myeloid zinc-finger 1 (MZF-1 (show ZFP42 Proteins)) and ferroportin (FPN).

  10. we demonstrated that downregulation of FPN1 plays critical roles in promoting myeloma cell growth and bone resorption in multiple myeloma.

Mouse (Murine) Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

  1. The results suggest that physiologic hepcidin (show HAMP Proteins) levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.

  2. In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 Proteins) and ferroportin expression levels were increased and hepatic hepcidin (show HAMP Proteins) mRNA expression and serum hepcidin (show HAMP Proteins) concentration were reduced.

  3. Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron.

  4. Results suggest that reduction in ferroportin levels in Alzheimer's disease brains are likely associated with cerebral ischaemia, inflammation, loss of neurons due to protein misfolding, senile plaque formation and possibly ageing process itself

  5. Oral iron failed to be utilized by Fpn-KO mice and was retained in enterocytes, irrespective of the iron source. Ferroportin-dependent efflux from enterocytes controls duodenal iron absorption.

  6. Genetic interactions between Cp, Mon1a (show MON1A Proteins), and the Slc40a1 locus are involved in iron metabolism.

  7. Hypoxia signal, stimulated erythropoietin (show EPO Proteins), which affected iron absorption by stabilizing duodenal ferroportin.

  8. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (show HAMP Proteins) remains labile and available to down-regulate Fpn1.

  9. Nitric oxide up-regulated the expression of ferroportin-1 (Fpn1), the major cellular iron exporter, in mouse and human cells.

  10. Ferroportin transcription following experimentally-induced acute anemia in mice is tissue-specific.

Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) Protein Profile

Protein Summary

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).

Gene names and symbols associated with SLC40A1

  • solute carrier family 40 (iron-regulated transporter), member 1 (slc40a1)
  • solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1)
  • Fe(2+) transport protein 1 (IRT1)
  • metal tolerance protein 1 short form (ZAT)
  • solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)
  • solute carrier family 40 member 1 (IREG1)
  • A. THALIANA CATION DIFFUSION FACILITATOR 1 protein
  • ARABIDOPSIS IRON-REGULATED TRANSPORTER 1 protein
  • ARABIDOPSIS THALIANA IRON-REGULATED PROTEIN 1 protein
  • ATCDF1 protein
  • ATIREG1 protein
  • ATIRT1 protein
  • ATMTP1 protein
  • Dusg protein
  • F19D11.8 protein
  • FERROPORTIN 1 protein
  • Fpn1 protein
  • HFE4 protein
  • IREG1 protein
  • iron-regulated transporter 1 protein
  • iron regulated 1 protein
  • MGC82700 protein
  • MST079 protein
  • MTP protein
  • MTP1 protein
  • Ol5 protein
  • Pcm protein
  • Slc11a3 protein
  • Slc39a1 protein
  • SLC40A1 protein
  • T16H5.50 protein
  • T16H5_50 protein
  • T19C21.5 protein
  • T19C21_5 protein
  • weh protein
  • ZAT1 protein
  • zinc transporter of Arabidopsis thaliana protein
  • ZINC TRANSPORTER OF ARABIDOPSIS THALIANA 1 protein
  • ZINC TRANSPORTER ZAT protein

Protein level used designations for SLC40A1

ferroportin-1 , ferroportin1 , iron-regulated transporter , solute carrier family 39 (iron-regulated transporter), member 1 , solute carrier family 40 member 1 , weissherbst , solute carrier family 40 (iron-regulated transporter), member 1 , ferroportin , solute carrier family 40 member 1-like , iron regulated gene 1 , putative ferroportin 1 variant IIIB , solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 , SLC11A3 iron transporter , duodenal-specific , ferroportin 1 , iron-regulated transporter 1 , metal transporter protein 1 , metal transporting protein 1 , polycythaemia , CAR1 , cell adhesion regulator

GENE ID SPECIES
58153 Danio rerio
423984 Gallus gallus
446661 Xenopus laevis
459821 Pan troglodytes
527023 Bos taurus
713321 Macaca mulatta
785185 Bos taurus
100036732 Xenopus (Silurana) tropicalis
100172551 Pongo abelii
100028485 Monodelphis domestica
100069190 Equus caballus
100474381 Ailuropoda melanoleuca
100588979 Nomascus leucogenys
827713 Arabidopsis thaliana
819293 Arabidopsis thaliana
30061 Homo sapiens
53945 Mus musculus
478837 Canis lupus familiaris
100512076 Sus scrofa
170840 Rattus norvegicus
818427 Arabidopsis thaliana
Selected quality suppliers for Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Proteins (SLC40A1)
Did you look for something else?