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SLC47A1 is located within the Smith-Magenis syndrome region on chromosome 17. Additionally we are shipping Solute Carrier Family 47, Member 1 Antibodies (43) and and many more products for this protein.
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Human SLC47A1 ELISA Kit for Sandwich ELISA - ABIN823375
Lee, Lee, Kim, Lee, Jun, Lee: Multidrug and toxic compound extrusion protein-1 (MATE1/SLC47A1) is a novel flavonoid transporter. in Journal of agricultural and food chemistry 2014
MATE1 has an external COOH terminus, consistent with a 13-helix topology, which may influence transporter turnover.
substrate identity exerts comparatively little influence on ligand interaction with MATE1.
MATE1 mRNA levels in peripheral blood cells were significantly higher in patients carrying the minor allele of rs2453579, but not rs2252281, compared to those with other genotypes
MATE1 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.
MATE1 rs2289669 may be a significant determinant in the renal clearance of metformin in the case of transporter-mediated drug interactions
Disease progression according to RECIST was also more frequent in carriers of at least one polymorphic MATE1 A-allele (44%) as compared with homozygous carriers of the wild-type G-allele (12.5%) (P=0.07). OCT1 (show POU2F1 ELISA Kits) and MATE1 were not associated with PFS.
MATE1 sequesters organic cations within an intracellular compartment that has no influence on secretion in renal proximal tubules.
SLC47A1 rs2289669 G>A variants improve the glucose-lowering effect of metformin through slowing its excretion in type 2 diabetes populations.
MRNA levels of multidrug and toxin extrusion protein 1 (MATE1 or SLC47A1, encoded by 1 of the 11 genes) were significantly lower in patients with FILI.
MATE1 is a membrane transporter for quercetin.MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum as well as in plasma membranes in the liver and intestine.
ADMA and L-arginine (show GATM ELISA Kits) are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine (show GATM ELISA Kits)
Mate1 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis.
MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum as well as in plasma membranes in the liver and intestine.
[(11)C]Metformin may be useful as a PET probe to non-invasively study the in vivo function of hepatobiliary transport and drug-drug interactions, mediated by MATE1 in future clinical investigations.
Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.
Homozygous MATE1 variant could be one of the risk factors for metformin-induced lactic acidosis.
MATE1 mediates the efflux of cisplatin and is involved in cisplatin-induced nephrotoxicity.
mMATE1 is polyspecific H(+)/(organic cation)OC exchanger. Unexpectedly wide distribution of mMATE1 suggests involvement in diverse biological functions other than excretion of OCs from the body. (Multidrug and toxin extrusion 1, MATE1)
mMATE1b is a functional variant of mMATE1 and seems to be the true counterpart to other MATE1 transporters
MATE1 mRNA levels were highest in the kidney, where male expression was higher than female.
This is the first report to demonstrate an essential role of MATE1 in systemic clearance of metformin.
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function.
solute carrier family 47, member 1
, multidrug and toxin extrusion protein 1
, solute carrier family 47 member 1
, multidrug and toxin extrusion 1
, H+/organic cation antiporter variant 1
, H+/organic cation antiporter variant 2