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Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 Proteins (SLC5A2)

SLC5A2 encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. Additionally we are shipping SLC5A2 Antibodies (40) and SLC5A2 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC5A2 6524 P31639
SLC5A2 246787 Q923I7
Rat SLC5A2 SLC5A2 64522 P53792
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Top SLC5A2 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

SLC5A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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Mouse (Murine) ,
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More Proteins for Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 (SLC5A2) Interaction Partners

Cow (Bovine) Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 (SLC5A2) interaction partners

  1. cloning and distribution of SGLT2 mRNA expression in bovine tissues; SGLT2 mRNA was detected predominantly in the kidney; expression of SGLT2 mRNA in mammary gland increased more than 10-fold from late pregnancy to early lactation

Human Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 (SLC5A2) interaction partners

  1. Mutations in the SLC5A2 gene did not find any evidence that chronic loss of glucose in the urine would protect from deterioration of the glucose tolerance over time.

  2. Data suggest that SGLT2 is transporter found in proximal renal tubules, responsible for reabsorption of most of glucose filtered by kidney; inhibition of SGLT2 lowers blood glucose level by promoting urinary excretion of excess glucose. [REVIEW]

  3. SGLT2 is functionally expressed in pancreatic and prostate adenocarcinomas

  4. Results identified six SLC5A2 variants including four novel variants in Chinese familial renal glucosuria. Variant SLC5A2 proteins had altered expression levels and patterns in addition to significantly lower glucose transport in cultured cells.

  5. SGLT2 inhibitor canagliflozin can be coadministered with oral contraceptives, warfarin, or digoxin without dose adjustments.

  6. SGLT2 is inhibited with dapagliflozin in pancreatic alpha cells, which triggers glucagon (show GCG Proteins) secretion

  7. Sodium glucose cotransporter 2 inhibitor empagliflozin is not associated with prolonged QT interval.

  8. A possible role of common genetic variation in SLC5A2 in the control of glucose homeostasis.

  9. Studies indcate that glucose is present in the glomerular filtrate and is reabsorbed by a group of transport proteins in the renal tubular epithelium, with sodium glucose transporter (SGLT)-2 quantitatively the most important.

  10. Data suggest that SGLT2 plays role in tubular apoptosis in diabetic nephropathy; SGLT2-mediated, high glucose-induced generation of reactive oxygen species appears to augment apoptosis of renal tubular cells.

Mouse (Murine) Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 (SLC5A2) interaction partners

  1. these results suggest that SGLT2i treatment acutely suppresses energy expenditure in BAT (show BAAT Proteins) via regulation of an inter-organ neural network consisting of the common hepatic vagal branch and sympathetic nerves.

  2. In conclusion, SGLT2 inhibitor luseogliflozin ameliorates glycemic control and thus exerts protective effects on pancreatic beta-cell mass and function.

  3. SGLT2 can transport gentamicin and contribute to gentamicin-induced cytotoxicity.

  4. SGLT2 is inhibited with dapagliflozin in pancreatic alpha cells, which triggers glucagon (show GCG Proteins) secretion

  5. DNA sequencing of SGLT2 in SAMP10/TaSlc mice revealed a single nucleotide deletion of guanine at 1236, which resulted in a frameshift mutation that produced a truncated protein.

  6. Improved glycemic control in mice lacking Sglt1 (show SLC5A1 Proteins) and Sglt2.

  7. Prevention of renal glucose reabsorption by SGLT2 deletion reduced hyperglycemia, improved glucose intolerance, and increased glucose-stimulated insulin (show INS Proteins) secretion in vivo.

  8. SGLT2 mediates glucose reabsorption in the early proximal tubule and most of the glucose reabsorption by the kidney, overall.

SLC5A2 Protein Profile

Protein Summary

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria.

Gene names and symbols associated with SLC5A2

  • solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2)
  • solute carrier family 5 (sodium/glucose cotransporter), member 2 (slc5a2)
  • solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2)
  • DKFZp469E0433 protein
  • MGC83377 protein
  • Sglt2 protein
  • slc5a2 protein
  • zgc:85792 protein

Protein level used designations for SLC5A2

sodium/glucose cotransporter 2 , solute carrier family 5 (sodium/glucose cotransporter), member 2 , Na(+)/glucose cotransporter 2 , low affinity sodium-glucose cotransporter , solute carrier family 5 (sodium/glucose transporter), member 2 , solute carrier family 5 member 2 , low affinity sodium-dependent glucose cotransporter , low affinity Na-dependent glucose transporter (SGLT2) , Na(+)/nucleoside cotransporter , Na+/nucleoside cotransporter , sodium/nucleoside cotransporter

GENE ID SPECIES
399680 Bos taurus
714228 Macaca mulatta
100136139 Oncorhynchus mykiss
100172191 Pongo abelii
405862 Danio rerio
447523 Xenopus laevis
100380144 Xenopus (Silurana) tropicalis
6524 Homo sapiens
246787 Mus musculus
64522 Rattus norvegicus
100009386 Oryctolagus cuniculus
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