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SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). Additionally we are shipping and many more products for this protein.
Showing 10 out of 64 products:
Human Polyclonal SLC5A8 Primary Antibody for WB - ABIN2781721
Zhang, Bao, Yang, Wu, Yu, Huang, Sun, Zheng, Li: Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells. in The international journal of biochemistry & cell biology 2010
Show all 3 Pubmed References
Human Polyclonal SLC5A8 Primary Antibody for WB - ABIN4892821
Nedjadi, Moran, Al-Rammahi, Shirazi-Beechey: Characterization of butyrate transport across the luminal membranes of equine large intestine. in Experimental physiology 2014
Show all 2 Pubmed References
Mouse (Murine) Polyclonal SLC5A8 Primary Antibody for WB - ABIN1881812
Cresci, Thangaraju, Mellinger, Liu, Ganapathy: Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8. in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2010
Slc5a8 is an obligatory link between dietary fibre and mucosal immune system via the bacterial metabolite butyrate and that this transporter is a conditional tumour suppressor in colon linked to dietary fibre content.
Data indicate oncogenic HRAS (HRAS (show HRAS Antibodies)(G12V)) as a potent mediator of SLC5A8 silencing in human nontransformed normal mammary epithelial cell lines and in mouse mammary tumors through DNMT1 (show DNMT1 Antibodies).
Efficacy of LP or their secreted soluble factors to stimulate SMCT1 expression and function and to counteract the inhibitory effects of TNF-alpha (show TNF Antibodies) on butyrate absorption could have potential therapeutic value.
butyrate and propionate block the generation of dendritic cells from bone marrow stem cells, since Slc5a8 transports butyrate and propionate into cells, and these two bacterial metabolites inhibit histone deacetylases
Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.
In conventional mice with normal bacterial colonization of the intestinal tract, GPR109A and SLC5A8 are expressed on the apical membrane of epithelial cells lining the ileum and colon.
CDX1 (show CDX1 Antibodies) and CDX2 (show CDX2 Antibodies) bind the promoter region of SLC5A8 and up-regulate its expression in cultured cells and in colonic epithelium.
slc5a8 is expressed abundantly in the kidney and plays a role in the active reabsorption of lactate
SMCT functions not only as a Na+-coupled transporter for short-chain fatty acids and lactate but also as a Na+-coupled transporter for the water-soluble vitamin nicotinic acid.
Data describe the cellular localization of Slc5a8 in the murine gastrointestinal tract and kidney by in situ hybridization and immunohistochemistry.
Human SMCT1 is regulated by insulin (show INS Antibodies) and SGK1 (show SGK1 Antibodies).
Data suggest positive correlation between BMI (body mass index)/waist circumference in morbidly obese or obese subjects and jejunal mucosa mRNA abundance of SMCT1; BMI was not significantly correlated with mRNA abundance for glucose transporters SGLT1 and GLUT2 or the low-affinity short-chain fatty acid/monocarboxylate transporter SMCT2.
Underexpression of SLC5A8 is associated with hepatocellular carcinoma.
Data suggest that SLC5A8, SLC5A5 (sodium-iodide symporter (show SLC5A5 Antibodies)), and SLC26A4 (pendrin (show SLC26A4 Antibodies)), the 3 known iodide transporters, are important in breast tissue metabolism in lactation and in breast neoplasms. [REVIEW]
Gene silencing of SLC5A8 by hypermethylation was associated with poor prognosis in cases of node-negative stage I and II lung adenocarcinoma.
These results suggest that DNA methylation (show HELLS Antibodies) in the SLC5A8 promoter region may suppress the expression of SLC5A8 in lung tumor.
SLC5A8 suppresses tumour progression through depletion of survivin (show BIRC5 Antibodies) without involving its transport function
SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma.
SLC5A8 has a role in prostate cancer risk and aggressiveness
SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002
apical iodide transporter , putative
, electrogenic sodium monocarboxylate cotransporter
, sodium-coupled monocarboxylate transporter 1
, solute carrier family 5 member 8
, sodium-dependent monocarboxylate cotransporter
, apical iodide transporter
, sodium iodide-related cotransporter
, solute carrier family 5 (iodide transporter), member 8