anti-Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) Antibodies

SLC5A5 encodes a member of the sodium glucose cotransporter family.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse SLC5A5 SLC5A5 114479  
Anti-Human SLC5A5 SLC5A5 6528 Q92911
Anti-Rat SLC5A5 SLC5A5 114613 Q63008
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More Antibodies against Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 Interaction Partners

Pig (Porcine) Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) interaction partners

  1. NIS, the major iodide transporter of the thyroid gland, is susceptible to DNA damage involving ATM (show ATM Antibodies)-mediated mechanisms.

  2. Morphogenetic signals modify the expression of NIS and recovery response to MEK (show MAP2K1 Antibodies) inhibition.

  3. Intracellular iodinated compounds affect NIS expression through the thyroid stimulating hormone-mediated cAMP-PKA and PLC (show PLC Antibodies)-IP3 pathways.

Mouse (Murine) Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) interaction partners

  1. Report noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using Slc5a5 transgenic mice.

  2. Cloning of the mouse sodium iodide symporter.

  3. The high degree of homology in the 5'-flanking region between mouse and rat NIS suggests that mNIS and rNIS share similar mechanisms for transcriptional regulation in the thyroid.

  4. This study represents a promising first step in investigations of the potential use of a combination of the NIS gene and MDR1 (show ABCB4 Antibodies) shRNA as a new therapeutic strategy allowing RNA interference-based gene therapy.

  5. The Na+/I- symporter mediates active iodide uptake in the intestine.

  6. High potential of novel pseudodendritic polymers for tumor-specific NIS gene delivery after systemic application, opening the prospect of targeted NIS-mediated radionuclide therapy of nonthyroidal tumors even in metastatic disease.

Human Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) interaction partners

  1. Results indicate that Na+/I- symporter (NIS) can be used as an objective used as an objective criterion for determining the sensitivity of luminal B and basal breast cancer (BC)subtypes to neoadjuvant chemotherapy (NACT (show SLC13A2 Antibodies)).

  2. Our findings indicated that hTERT promoter-driven expression of the NIS gene in HeLa cells led to 188Re uptake and therapeutic effects. Thus, NIS-based gene therapy and imaging using the hTERT promoter and 188Re may be possible.

  3. SLC5A5 was down-regulated in FTC (show FUT2 Antibodies) and PTC (show F9 Antibodies). Its expression could be modulated by hsa (show CD24 Antibodies)-let-7f-5p. ATC (show SRPK1 Antibodies) showed a loss of SLC5A5/hsa (show CD24 Antibodies)-let7f-5p correlation

  4. Mutating the sites located on the C-terminal domain of the protein has no effect except for the creation of a diacidic motif that decreases the total NIS protein level without affecting its expression at the plasma membrane.

  5. Therefore, enhancing functional NIS by the increasing level of glycosylation may be suggested as a promising therapeutic strategy for cancer patients who show refractory response to conventional radioiodine treatment.

  6. Our results confirmed that NIS overexpression enhances the sensitivity of ER-negative breast cancer cells to radioiodide therapy.

  7. miR (show MLXIP Antibodies)-146b-3p binds to the 3'-untranslated region of PAX8 (show PAX8 Antibodies) and sodium/iodide symporter, leading to impaired protein translation and a subsequent reduction in iodide uptake.

  8. Study demonstrates an association of one variant and several haplotypes of the NIS gene with differentiated thyroid cancer.

  9. Data suggest that SLC5A5, SLC5A8 (sodium-coupled monocarboxylate transporter 1 (show SLC5A8 Antibodies)), and SLC26A4 (pendrin (show SLC26A4 Antibodies)), the 3 known iodide transporters, are important in breast tissue metabolism in lactation and in breast neoplasms. [REVIEW]

  10. Real time PCR revealed that both cell lines express mRNA of lactoferrin (show LTF Antibodies) receptors while flow cytometry and confocal microscopy showed the cells efficiently internalize bLf which upregulates NIS expression.

Solute Carrier Family 5 (Sodium Iodide Symporter), Member 5 (SLC5A5) Antigen Profile

Protein Summary

This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.

Gene names and symbols associated with SLC5A5

  • solute carrier family 5 (sodium iodide symporter), member 5 (SLC5A5) antibody
  • solute carrier family 5 (sodium iodide symporter), member 5 (slc5a5) antibody
  • sodium iodide symporter (RB8797) antibody
  • sodium iodide symporter (RB2501_13734) antibody
  • sodium iodide symporter (CA2559_12043) antibody
  • sodium iodide symporter (FB2170_10479) antibody
  • solute carrier family 5 (sodium iodide symporter), member 5 (Slc5a5) antibody
  • solute carrier family 5 (sodium/iodide cotransporter), member 5 (SLC5A5) antibody
  • solute carrier family 5 (sodium/iodide cotransporter), member 5 (Slc5a5) antibody
  • MGC84602 antibody
  • Nis antibody
  • si:ch211-200a16.4 antibody
  • SLC5A5 antibody
  • TDH1 antibody

Protein level used designations for SLC5A5

solute carrier family 5 (sodium iodide symporter), member 5 , NIS , sodium/iodide cotransporter , sodium/iodide cotransporter-like , solute carrier family 5 member 5 , sodium iodide symporter , solute carrier family 5, member 5 , Na(+)/I(-) cotransporter , Na(+)/I(-) symporter , Na(+)/I(-)-symporter , sodium-iodide symporter , Na+/I- symporter

GENE ID SPECIES
431544 Gallus gallus
446726 Xenopus laevis
468767 Pan troglodytes
484830 Canis lupus familiaris
505310 Bos taurus
561445 Danio rerio
100144711 Xenopus (Silurana) tropicalis
100397857 Callithrix jacchus
100431462 Pongo abelii
100462701 Gasterosteus aculeatus
1794611 Rhodopirellula baltica SH 1
8456450 Robiginitalea biformata HTCC2501
9297898 Croceibacter atlanticus HTCC2559
9719699 Maribacter sp. HTCC2170
399542 Sus scrofa
114479 Mus musculus
6528 Homo sapiens
114613 Rattus norvegicus
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