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Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 Proteins (SLC6A3)

SLC6A3 encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. Additionally we are shipping SLC6A3 Antibodies (108) and SLC6A3 Kits (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC6A3 13162 Q61327
SLC6A3 6531 Q01959
SLC6A3 24898 P23977
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Top SLC6A3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$774.40
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

SLC6A3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , ,
, ,
Rat (Rattus)

More Proteins for Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) Interaction Partners

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) interaction partners

  1. DNA of the impulsive but not the calm subjects was methylated at one DAT SNP.

  2. nitrative damage accumulates in midbrain neurons with age; The capacity of a dopamine neuron to accumulate more cytosolic DA, as inferred from DA transporter expression, is related to accumulation of nitrative damage

Caenorhabditis elegans (C. elegans) Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) interaction partners

  1. Endogenous dopamine actions in C. elegans are tightly regulated by synaptic DAT-1.

  2. loss of UNC-64/DAT-1 interactions leads to enhanced synaptic dopamine release

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) interaction partners

  1. Data suggest that environment pollutants methylmercury and 1-methyl-4-phenylpyridinium decrease release of dopamine from dopaminergic neurons; this mechanism involves down-regulation of expression of Slc6a3.

  2. This study show that Dopamine transporter is enriched in filopodia and induces filopodia formation.

  3. The sigma-1R deficiency through suppressing NR2B (show GRIN2B Proteins) function and DAT expression can reduce MPTP (show PTPN2 Proteins)-induced death of dopaminergic neurons and parkinsonism.

  4. DAT gene knockout in mice results dendritic spine loss in pyramidal neurons in the CA1 (show CA1 Proteins) field of the hippocampus.

  5. Results show that moderate increases in DAT function cause spontaneous dopaminergic cell loss, oxidative stress and fine motor impairment that is reversed by l-DOPA treatment

  6. Chronic and acute reductions of DAT functioning in mice impaired decision-making.

  7. These results demonstrate that the presence of the N-terminal tag leads to impaired DAT protein expression in vivo due in part to improper trafficking of the tagged transporter.

  8. studies demonstrate an in vivo functional impact of the DAT Val559 variant, providing support for the ability of DAT dysfunction to impact risk for mental illness.

  9. The data of this study imply that individual differences in DAT expression (either genetically or pharmacologically induced) may affect susceptibility to addiction of different types of psychostimulants.

  10. findings support the idea that altered DAT and VMAT2 (show Slc18a2 Proteins) expression affect age-related changes in dopaminergic function.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) interaction partners

  1. DAT-mediated dopamine uptake plays a role in the absorption and distribution of dopamine following intranasal administration

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) interaction partners

  1. Study failed to observe a significant association of the SLC6A3 40-base pair variable number of tandem repeats polymorphism (rs28363170) with cognitive function in healthy adults

  2. the 3'-UTR VNTR polymorphism is significantly associated with smoking cessation, and smokers with one or more 9-repeat alleles have a 17% higher probability of smoking cessation than smokers carrying no such allele. [meta-analysis]

  3. high SLC6A3 expression in Clear cell renal cell carcinoma (show MOK Proteins) tissue was correlated with a shorter period of recurrence-free survival following surgery.

  4. Children without the haplotypes associated with the reduced SLC6A3 gene expression and thus lower dopamine functioning appeared to demonstrate altered levels of effortful control as a function of maternal parenting quality.

  5. Computational study providse novel insights into the role of collective dynamics in functionally relevant state-to-state transitions in DAT, at a level of atomistic detail

  6. Higher levels of maternal depressive symptoms predicted reduced cortisol flexibility across challenges for infants with at least one A1 allele of DRD2 (show DRD2 Proteins) and infants with the 10/10 genotype of SLC6A3

  7. 3'-UTR variable number tandem repeat associated with post-traumatic stress disorder [meta-analysis]

  8. The NET and DAT N Termini Are Critical for Internalization and Postendocytic Sorting.

  9. the putative involvement of DAT1 and DRD4 (show DRD4 Proteins) genes in the aetiology of Attention-deficit hyperactivity disorder with a main role in modulation of key dimensions of the disorder

  10. we did not find any significant associations of COMT (show COMT Proteins) or SLC6A3 with inhibitory performance or impulsivity

SLC6A3 Protein Profile

Protein Summary

This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.

Gene names and symbols associated with SLC6A3

  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (SLC6A3)
  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (slc6a3)
  • Protein DAT-1 (dat-1)
  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (Slc6a3)
  • solute carrier family 6 (neurotransmitter transporter), member 3 (SLC6A3)
  • solute carrier family 6 (neurotransmitter transporter), member 3 (Slc6a3)
  • DAT protein
  • DAT1 protein
  • PKDYS protein
  • SLC6A3 protein

Protein level used designations for SLC6A3

dopamine transporter variant II , sodium-dependent dopamine transporter , solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 , sodium-dependent dopamine transporter-like , DA transporter , dopamine transporter 1 , solute carrier family 6 member 3 , DAT , solute carrier family 6, member 3

GENE ID SPECIES
574143 Macaca mulatta
609304 Canis lupus familiaris
750842 Pan troglodytes
100054747 Equus caballus
100393968 Callithrix jacchus
100478402 Ailuropoda melanoleuca
100488824 Xenopus (Silurana) tropicalis
176304 Caenorhabditis elegans
13162 Mus musculus
788410 Bos taurus
6531 Homo sapiens
24898 Rattus norvegicus
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